Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus - Wikidata - thesis-toulmin - TriplyDB

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

http://www.wikidata.org/entity/Q24538808

about

The transcriptional co-activator LEDGF/p75 displays a dynamic scan-and-lock mechanism for chromatin tethering Virological and cellular roles of the transcriptional coactivator LEDGF/p75 LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration Identification of novel nuclear targets of human thioredoxin 1 Functional and structural characterization of the integrase from the prototype foamy virus New Class of HIV-1 Integrase (IN) Inhibitors with a Dual Mode of Action Retroviral integration: Site matters: Mechanisms and consequences of retroviral integration site selection LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors Non-catalytic site HIV-1 integrase inhibitors disrupt core maturation and induce a reverse transcription block in target cells Retroviral DNA Integration LEDGF dominant interference proteins demonstrate prenuclear exposure of HIV-1 integrase and synergize with LEDGF depletion to destroy viral infectivity Characterization of LEDGF/p75 genetic variants and association with HIV-1 disease progression.Differential effects of human immunodeficiency virus type 1 capsid and cellular factors nucleoporin 153 and LEDGF/p75 on the efficiency and specificity of viral DNA integration HRP2 determines the efficiency and specificity of HIV-1 integration in LEDGF/p75 knockout cells but does not contribute to the antiviral activity of a potent LEDGF/p75-binding site integrase inhibitor.Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV.Role of PSIP1/LEDGF/p75 in lentiviral infectivity and integration targeting.The lentiviral integrase binding protein LEDGF/p75 and HIV-1 replication.Mass spectrometry-based footprinting of protein-protein interactions Dynamics of the ternary complex formed by c-Myc interactor JPO2, transcriptional co-activator LEDGF/p75, and chromatin.The foamy virus genome remains unintegrated in the nuclei of G1/S phase-arrested cells, and integrase is critical for preintegration complex transport into the nucleus.LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin.Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration.Changes in the accessibility of the HIV-1 Integrase C-terminus in the presence of cellular proteins.HIV-1 IN inhibitors: 2010 update and perspectives Mechanisms and inhibition of HIV integration Zinc finger endonuclease targeting PSIP1 inhibits HIV-1 integration.The HIV-1 integrase mutant R263A/K264A is 2-fold defective for TRN-SR2 binding and viral nuclear import.LEDGF/p75-independent HIV-1 replication demonstrates a role for HRP-2 and remains sensitive to inhibition by LEDGINs Molecular mechanisms of retroviral integration site selection.Retroviral integrase proteins and HIV-1 DNA integration Comparison Between Several Integrase-defective Lentiviral Vectors Reveals Increased Integration of an HIV Vector Bearing a D167H Mutant.HIV infection of non-dividing cells: a divisive problem.HIV-1 IN/Pol recruits LEDGF/p75 into viral particles Repair of oxidative DNA base damage in the host genome influences the HIV integration site sequence preference.Retroviral integration site selection.Retroviral vectors: post entry events and genomic alterations.FRET analysis reveals distinct conformations of IN tetramers in the presence of viral DNA or LEDGF/p75.Association of polymorphisms in the LEDGF/p75 gene (PSIP1) with susceptibility to HIV-1 infection and disease progression.Transcriptional coactivator LEDGF/p75 modulates human immunodeficiency virus type 1 integrase-mediated concerted integration.Role of the PWWP domain of lens epithelium-derived growth factor (LEDGF)/p75 cofactor in lentiviral integration targeting

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Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus

http://www.wikidata.org/entity/Q24538808

description

2006 nî lūn-bûn

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2006 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2006 թվականի փետրվարին հրատարակված գիտական հոդված

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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name

Transient and stable knockdown ...... f human immunodeficiency virus

@ast

Transient and stable knockdown ...... f human immunodeficiency virus

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Transient and stable knockdown ...... f human immunodeficiency virus

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type

label

Transient and stable knockdown ...... f human immunodeficiency virus

@ast

Transient and stable knockdown ...... f human immunodeficiency virus

@en

Transient and stable knockdown ...... f human immunodeficiency virus

@nl

prefLabel

Transient and stable knockdown ...... f human immunodeficiency virus

@ast

Transient and stable knockdown ...... f human immunodeficiency virus

@en

Transient and stable knockdown ...... f human immunodeficiency virus

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JVI.80.4.1886-1896.2006

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Journal of Virology

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Transient and stable knockdown ...... f human immunodeficiency virus

@en

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Chris Van den Haute

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Jan De Rijck

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Myriam Witvrouw

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Rik Gijsbers

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P2860

A novel transcriptional coactivator, p52, functionally interacts with the essential splicing factor ASF/SF2

LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells

Purification and biochemical heterogeneity of the mammalian SWI-SNF complex

Binding and stimulation of HIV-1 integrase by a human homolog of yeast transcription factor SNF5

LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes

Protection of retroviral DNA from autointegration: involvement of a cellular factor

Retrovirus-delivered siRNA

Lens epithelium-derived growth factor: effects on growth and survival of lens epithelial cells, keratinocytes, and fibroblasts

Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress

HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells

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1886-96

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10.1128/JVI.80.4.1886-1896.2006

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4

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80

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Linos Vandekerckhove

Bénédicte Van Maele

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7333210

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