Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences - Wikidata - thesis-toulmin - TriplyDB

Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences

Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences

http://www.wikidata.org/entity/Q24555744

about

Single, double and quadruple alanine substitutions at oligomeric interfaces identify hydrophobicity as the key determinant of human neutrophil alpha defensin HNP1 function Humanized theta-defensins (retrocyclins) enhance macrophage performance and protect mice from experimental anthrax infections Sometimes it takes two to tango: contributions of dimerization to functions of human α-defensin HNP1 peptide Invariant gly residue is important for α-defensin folding, dimerization, and function: a case study of the human neutrophil α-defensin HNP1 Trp-26 imparts functional versatility to human alpha-defensin HNP1 Through the looking glass, mechanistic insights from enantiomeric human defensins Human monoclonal antibodies against anthrax lethal factor and protective antigen act independently to protect against Bacillus anthracis infection and enhance endogenous immunity to anthrax Cellular and physiological effects of anthrax exotoxin and its relevance to disease.Structural and Functional Analysis of the Pro-Domain of Human Cathelicidin, LL-37 Functional Determinants of Human Enteric -Defensin HD5: CRUCIAL ROLE FOR HYDROPHOBICITY AT DIMER INTERFACE Kinetics of lethal factor and poly-D-glutamic acid antigenemia during inhalation anthrax in rhesus macaques Defensins as anti-inflammatory compounds and mucosal adjuvants Cationic host defense peptides; novel antimicrobial therapeutics against Category A pathogens and emerging infections.Identification of novel non-hydroxamate anthrax toxin lethal factor inhibitors by topomeric searching, docking and scoring, and in vitro screening.Differential analysis of Bacillus anthracis after pX01 plasmid curing and comprehensive data on Bacillus anthracis infection in macrophages and glial cells.Microbicidal effects of α- and θ-defensins against antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa.ADP-ribosyltransferase-specific modification of human neutrophil peptide-1.Passive protection against anthrax by using a high-affinity antitoxin antibody fragment lacking an Fc region Development of a comprehensive, validated pharmacophore hypothesis for anthrax toxin lethal factor (LF) inhibitors using genetic algorithms, Pareto scoring, and structural biology.Comparative genomics and evolution of the alpha-defensin multigene family in primates Human alpha-defensins block papillomavirus infection Arginine-specific mono ADP-ribosylation in vitro of antimicrobial peptides by ADP-ribosylating toxins Why is the Arg5-Glu13 salt bridge conserved in mammalian alpha-defensins?Cathelicidin administration protects mice from Bacillus anthracis spore challenge Human defensins facilitate local unfolding of thermodynamically unstable regions of bacterial protein toxins.Molecular determinants for a cardiovascular collapse in anthrax Designing inhibitors of anthrax toxin High-sensitivity MALDI-TOF MS quantification of anthrax lethal toxin for diagnostics and evaluation of medical countermeasures Mucroporin-M1 inhibits hepatitis B virus replication by activating the mitogen-activated protein kinase (MAPK) pathway and down-regulating HNF4α in vitro and in vivo Antiinflammatory cAMP signaling and cell migration genes co-opted by the anthrax bacillus Retrocyclins kill bacilli and germinating spores of Bacillus anthracis and inactivate anthrax lethal toxin Bacillus anthracis: interactions with the host and establishment of inhalational anthrax.Potential biological targets of Bacillus anthracis in anti-infective approaches against the threat of bioterrorism.Human antimicrobial proteins effectors of innate immunity.Clostridium difficile associated infection, diarrhea and colitis Cellular response to Trypanosoma cruzi infection induces secretion of defensin α-1, which damages the flagellum, neutralizes trypanosome motility, and inhibits infection.Retrocyclins neutralize bacterial toxins by potentiating their unfolding.α-Defensins in human innate immunity.Immunotherapy for pulmonary TB: antimicrobial peptides and their inducers.Oral inflammation, a role for antimicrobial peptide modulation of cytokine and chemokine responses.

P2860

Q21132446-E36A8E39-3159-4F66-B29F-BD72CD22FB97 Q24607197-7D64B258-39ED-4732-ADB9-CD8D35BCB771 Q24613395-7AA906D1-B23B-4D15-95CF-561C63724900 Q24613723-86E2D62E-F560-46E4-8C65-BE4557301767 Q24615312-B072790A-0109-4454-82CB-0C2630B488FA Q24652382-3C2629DF-F570-4F39-B585-B62DBBB7A7B7 Q24682011-3B7D4EB3-97D9-48D8-A9D0-0C0D4ED1E4CC Q27010363-F6CBA140-30BC-488D-BD96-B4A16D562ACA Q27676356-6A531A3F-96EB-49AE-891B-BE772C1D70B6 Q27678985-C8D16297-F8D0-44BE-A80C-1CE860A163CA Q28389893-AE1D2D95-561E-464C-880F-152B071D05D8 Q28748926-4D3111AE-C20B-4E96-836F-0C54A5285731 Q30151971-452059D4-D624-4712-8741-0E36E586CBF4 Q30478430-9535A881-71E2-469E-A78B-B9C9DC7BA9C5 Q31129954-FD18FF1E-C31B-4E9D-BE36-3BBFB475358E Q33774311-A03DC22B-0E8D-496A-BFB4-07FB27AAC795 Q33995205-2DA63ADD-960E-484B-8D34-C194E4CEC63F Q34194728-84782052-9A74-4F04-AF6F-4525493D90FE Q34304133-BDF59053-0FAD-4865-9525-F5C142337EE1 Q34310619-41CD16ED-FB7B-437A-8028-5DFE78B11CEE Q34334899-3C9D8EBC-8A7B-4F95-A5CE-985DACB7CE13 Q34374003-26452E57-3F45-4215-8CE6-6B89D3F23359 Q34462507-0E89E9F2-B582-427F-9EE0-365BBE3D09A1 Q34476038-5D11EAF3-5D70-46C9-8F22-059B1014CEAC Q34727874-AC78E96E-FEBD-4F27-A239-E6760291E243 Q34960975-B7B396DE-B94A-460B-A02A-997F28930842 Q35018313-4F10ECA6-0E95-4894-A15A-D66BD4AB449E Q35205013-AA77D27B-238C-4943-8651-0D812A6EEF1C Q36216315-892BB896-9C66-4E19-9431-0D78CCC5CEB7 Q36579365-8EAAC3ED-2859-4A0B-85FB-87BD285A11F8 Q36737682-F4BA4360-7425-46A9-8AC7-794F65692592 Q36895609-622457E8-4472-4305-86A4-E5E500465708 Q36901955-53B3C752-2546-4671-A73C-B7A5400A08D5 Q37053332-2949D670-F891-48D7-A132-D339ABBFA4DF Q37160538-AEE16759-3B2A-43C4-A4B8-8ABCAE18F8B1 Q37264811-1E23F4F2-AD03-4857-9DE7-43EBE20325E6 Q37545884-3FA74BCB-9589-45CC-A143-57849EF8F92F Q37968296-AE4E0AD4-AB73-4C1B-BA56-F5D6007A0DFB Q38148589-85FB64D8-9EBA-4383-985F-24AD262C832B Q38152470-887C1761-4F6B-4332-B851-832DE2415B2E

P2860

Human alpha-defensins neutralize anthrax lethal toxin and protect against its fatal consequences

http://www.wikidata.org/entity/Q24555744

description

2005 nî lūn-bûn

@nan

2005 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի մարտին հրատարակված գիտական հոդված

@hy

2005年の論文

@ja

2005年論文

@yue

2005年論文

@zh-hant

2005年論文

@zh-hk

2005年論文

@zh-mo

2005年論文

@zh-tw

2005年论文

@wuu

name

Human alpha-defensins neutrali ...... against its fatal consequences

@ast

Human alpha-defensins neutrali ...... against its fatal consequences

@en

Human alpha-defensins neutrali ...... against its fatal consequences

@nl

type

label

Human alpha-defensins neutrali ...... against its fatal consequences

@ast

Human alpha-defensins neutrali ...... against its fatal consequences

@en

Human alpha-defensins neutrali ...... against its fatal consequences

@nl

prefLabel

Human alpha-defensins neutrali ...... against its fatal consequences

@ast

Human alpha-defensins neutrali ...... against its fatal consequences

@en

Human alpha-defensins neutrali ...... against its fatal consequences

@nl

P1433

Q24555744-17678B3C-314F-4E2E-A59B-4B553C7D72DE

P1476

Q24555744-E09F0363-30FF-443F-BC51-DE255DBCEE3A

P2093

Q24555744-16D43A4C-45AC-4016-8BEA-4B960E9FAC39

Q24555744-1763F0CA-BD16-44B0-9F78-37F244C3E829

Q24555744-1D7543E0-F550-4FD8-92E3-3EA85979398D

Q24555744-D458DEC0-0D29-4B9F-A2AF-4825592F2A65

Q24555744-F05B04C3-BECB-438E-913C-1CEE4F5D9775

Q24555744-F7171D0C-1763-4DE9-B1EA-4AB496F429E5

Q24555744-F8600FB4-E02E-44DF-817B-9440EEA61F18

P2860

Q24555744-016C1304-803B-468C-868A-195CD641062A

Q24555744-116CCB82-961C-4AA8-8FC4-F2E4C420117C

Q24555744-1615B468-9402-4833-8134-70684C07F8BA

Q24555744-16272C48-BD19-4553-9E44-D221FBD309F8

Q24555744-2690211D-673A-425D-A808-0D03F4D5BA56

Q24555744-27CEDE59-5F1E-49D2-9390-B1FDDBE10969

Q24555744-30A32CF3-52FD-4091-A527-AA70FA0BFFF1

Q24555744-30A42FEA-67AF-4564-BF80-E224EFD2ED34

Q24555744-4F51CE4F-9FDF-4669-821E-00271D53E2C4

Q24555744-4FF26088-8095-4EBD-B679-48B13C17B7BF

P304

Q24555744-EA69759A-3A4C-4E2B-AE1B-EC073207156D

P31

Q24555744-C08E078A-166E-4033-8CE4-CA34E2ED3FE3

P356

Q24555744-8B1D6B20-5A0A-4C90-BC7F-597CC77FB86A

P407

Q24555744-D3776B52-E195-4ADD-B0B7-8C2D24A6C885

P433

Q24555744-AF05E5A6-AF50-462D-BB10-0AB07FD7080F

P478

Q24555744-D535A481-752F-4BBF-BD93-D906301136FD

P50

Q24555744-1466CCF9-C033-418F-9388-7D143063475A

Q24555744-3B092E82-C24E-4080-B5C1-7777A25D37DF

Q24555744-BC17BE8B-0D53-4B2A-8C9A-5EEC65ECC46F

P577

Q24555744-DFC4D3EF-D591-4103-989B-D916F98EBEB9

P5875

Q24555744-298892DA-BF0F-40D2-9BA8-06EB37E7B9DD

P698

Q24555744-ACE7869D-ED01-407D-8450-1FB49BE7B90A

P932

Q24555744-3FEB7C21-64CE-4339-B6BA-24AD125DEF13

P356

PNAS.0500508102

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Human alpha-defensins neutrali ...... against its fatal consequences

@en

P2093

Chun Kim

http://www.w3.org/2001/XMLSchema#string

Gunter Fischer

http://www.w3.org/2001/XMLSchema#string

Hans-Willi Mittrücker

http://www.w3.org/2001/XMLSchema#string

Matthias Weiwad

http://www.w3.org/2001/XMLSchema#string

Nadesan Gajendran

http://www.w3.org/2001/XMLSchema#string

Robert Hurwitz

http://www.w3.org/2001/XMLSchema#string

Young-Hwa Song

http://www.w3.org/2001/XMLSchema#string

P2860

Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells

Defensins. Natural peptide antibiotics of human neutrophils

Contribution of individual toxin components to virulence of Bacillus anthracis

The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor

Identification of small molecule inhibitors of anthrax lethal factor

The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations

Identification of the cellular receptor for anthrax toxin

Defensins: antimicrobial peptides of innate immunity

Plasma defensin concentrations are elevated in patients with septicemia or bacterial meningitis

Defensins: antimicrobial and cytotoxic peptides of mammalian cells

P304

4830-5

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.0500508102

http://www.w3.org/2001/XMLSchema#string

P407

P433

13

http://www.w3.org/2001/XMLSchema#string

P478

102

http://www.w3.org/2001/XMLSchema#string

P50

Matthias Wilmanns

Stefan Kaufmann

Hans-Willi Mittrücker

P577

2005-03-29T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

235606427

http://www.w3.org/2001/XMLSchema#string

P698

15772169

http://www.w3.org/2001/XMLSchema#string

P932

555714

http://www.w3.org/2001/XMLSchema#string