GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I
about
GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cellsThe import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chainTIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complexIdentification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunitsTyk2 tyrosine kinase expression is required for the maintenance of mitochondrial respiration in primary pro-B lymphocytesPivotal Importance of STAT3 in Protecting the Heart from Acute and Chronic Stress: New Advancement and Unresolved IssuesIron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null miceThe mitochondrial serine protease HtrA2/Omi: an overviewDifferentially expressed proteins in malignant and benign adrenocortical tumorsThe mitochondrial respiratory chain controls intracellular calcium signaling and NFAT activity essential for heart formation in Xenopus laevis.Mutation in NDUFA13/GRIM19 leads to early onset hypotonia, dyskinesia and sensorial deficiencies, and mitochondrial complex I instability.A proof-of-principle study of epigenetic therapy added to neoadjuvant doxorubicin cyclophosphamide for locally advanced breast cancer.The U95 protein of human herpesvirus 6B interacts with human GRIM-19: silencing of U95 expression reduces viral load and abrogates loss of mitochondrial membrane potentialGRIM-19 and p16(INK4a) synergistically regulate cell cycle progression and E2F1-responsive gene expression.Interferons, signal transduction pathways, and the central nervous system.Identification of a structural motif in the tumor-suppressive protein GRIM-19 required for its antitumor activityGRIM-19 Expression and Function in Human Gliomas.Cytokine-induced tumor suppressors: a GRIM storyOlfactomedin 4 is a novel target gene of retinoic acids and 5-aza-2'-deoxycytidine involved in human myeloid leukemia cell growth, differentiation, and apoptosis.Maternal enzyme masks the phenotype of mouse embryos lacking dihydrolipoamide dehydrogenase.Stability, delivery and functions of human sperm RNAs at fertilization.Genetic determinants of phosphate response in Drosophila.Overexpression of GRIM-19, a mitochondrial respiratory chain complex I protein, suppresses hepatocellular carcinoma growth.Downregulation of gene expression and activity of GRIM-19 affects mouse oocyte viability, maturation, embryo development and implantationNeonatal exposure to lipopolysaccharide enhances vulnerability of nigrostriatal dopaminergic neurons to rotenone neurotoxicity in later life.Mitochondrial-targeted Signal transducer and activator of transcription 3 (STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen speciesInitiation of electron transport chain activity in the embryonic heart coincides with the activation of mitochondrial complex 1 and the formation of supercomplexes.Caenorhabditis elegans expressing the Saccharomyces cerevisiae NADH alternative dehydrogenase Ndi1p, as a tool to identify new genes involved in complex I related diseases.Mitochondrial STAT3 contributes to transformation of Barrett's epithelial cells that express oncogenic Ras in a p53-independent fashionHigh Glucose Induces Down-Regulated GRIM-19 Expression to Activate STAT3 Signaling and Promote Cell Proliferation in Cell CultureGhMCS1, the Cotton Orthologue of Human GRIM-19, Is a Subunit of Mitochondrial Complex I and Associated with Cotton Fibre Growth.Function of GRIM-19, a mitochondrial respiratory chain complex I protein, in innate immunity.Building the mitochondrial proteome.Genetic insights into OXPHOS defect and its role in cancerMitochondrial respiratory complex I: structure, function and implication in human diseases.Somatic and germline mutation in GRIM-19, a dual function gene involved in mitochondrial metabolism and cell death, is linked to mitochondrion-rich (Hurthle cell) tumours of the thyroid.GRIM-19 is essential for maintenance of mitochondrial membrane potential.Tumor-derived mutations in the gene associated with retinoid interferon-induced mortality (GRIM-19) disrupt its anti-signal transducer and activator of transcription 3 (STAT3) activity and promote oncogenesis.The IFN-beta and retinoic acid-induced cell death regulator GRIM-19 is upregulated during focal cerebral ischemia.GRIM19 ameliorates acute graft-versus-host disease (GVHD) by modulating Th17 and Treg cell balance through down-regulation of STAT3 and NF-AT activation.
P2860
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P2860
GRIM-19, a cell death regulatory protein, is essential for assembly and function of mitochondrial complex I
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年論文
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2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
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2004年论文
@wuu
name
GRIM-19, a cell death regulato ...... ion of mitochondrial complex I
@ast
GRIM-19, a cell death regulato ...... ion of mitochondrial complex I
@en
GRIM-19, a cell death regulato ...... ion of mitochondrial complex I
@nl
type
label
GRIM-19, a cell death regulato ...... ion of mitochondrial complex I
@ast
GRIM-19, a cell death regulato ...... ion of mitochondrial complex I
@en
GRIM-19, a cell death regulato ...... ion of mitochondrial complex I
@nl
prefLabel
GRIM-19, a cell death regulato ...... ion of mitochondrial complex I
@ast
GRIM-19, a cell death regulato ...... ion of mitochondrial complex I
@en
GRIM-19, a cell death regulato ...... ion of mitochondrial complex I
@nl
P2093
P2860
P3181
P1476
GRIM-19, a cell death regulato ...... ion of mitochondrial complex I
@en
P2093
Chengchen Lufei
Guochang Huang
Sathivel Ponniah
Xinmin Cao
P2860
P304
P3181
P356
10.1128/MCB.24.19.8447-8456.2004
P407
P50
P577
2004-10-01T00:00:00Z