Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase
about
Nuclear and mitochondrial uracil-DNA glycosylases are generated by alternative splicing and transcription from different positions in the UNG geneLesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNAMutational analysis of the damage-recognition and catalytic mechanism of human SMUG1 DNA glycosylaseminifly, a Drosophila gene required for ribosome biogenesisThe alpha/beta fold uracil DNA glycosylases: a common origin with diverse fatesDNA glycosylases: in DNA repair and beyondUracil DNA N-glycosylase promotes assembly of human centromere protein AEnzymatic capture of an extrahelical thymine in the search for uracil in DNAIsolation and identification of genes activating UAS2-dependent ADH2 expression in Saccharomyces cerevisiae.Uracil-DNA glycosylase-deficient yeast exhibit a mitochondrial mutator phenotype.Role of base excision repair in maintaining the genetic and epigenetic integrity of CpG sitesUracil-DNA glycosylase: Structural, thermodynamic and kinetic aspects of lesion search and recognitionA quantitative model of human DNA base excision repair. I. Mechanistic insights.The efficiency of the translesion synthesis across abasic sites by mitochondrial DNA polymerase is low in mitochondria of 3T3 cellsMutational analysis of arginine 276 in the leucine-loop of human uracil-DNA glycosylase.Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behaviorUracil DNA glycosylase (UDG) activities in Bradyrhizobium diazoefficiens: characterization of a new class of UDG with broad substrate specificity.Release of normal bases from intact DNA by a native DNA repair enzyme.Base excision repair initiation revealed by crystal structures and binding kinetics of human uracil-DNA glycosylase with DNA.Imbalanced base excision repair increases spontaneous mutation and alkylation sensitivity in Escherichia coli.Mutagenic specificity of endogenously generated abasic sites in Saccharomyces cerevisiae chromosomal DNAA one-step method for quantitative determination of uracil in DNA by real-time PCR.B cells from hyper-IgM patients carrying UNG mutations lack ability to remove uracil from ssDNA and have elevated genomic uracil.Mutations at Arginine 276 transform human uracil-DNA glycosylase into a single-stranded DNA-specific uracil-DNA glycosylase.Generation of a strong mutator phenotype in yeast by imbalanced base excision repair.Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.Phylogenomic analysis of the uracil-DNA glycosylase superfamilyA structural determinant in the uracil DNA glycosylase superfamily for the removal of uracil from adenine/uracil base pairsA mutant of uracil DNA glycosylase that distinguishes between cytosine and 5-methylcytosineSwitching base preferences of mismatch cleavage in endonuclease V: an improved method for scanning point mutationsCombining H/D exchange mass spectroscopy and computational docking reveals extended DNA-binding surface on uracil-DNA glycosylase.Dependence of antibody gene diversification on uracil excision.Mechanisms of glycosylase induced genomic instabilityInducible DNA breaks in Ig S regions are dependent on AID and UNGHarnessing mutagenic homologous recombination for targeted mutagenesis in vivo by TaGTEAM.Uracil DNA glycosylase uses DNA hopping and short-range sliding to trap extrahelical uracils.Persistent damage induces mitochondrial DNA degradation.Roles of Rev1, Pol zeta, Pol32 and Pol eta in the bypass of chromosomal abasic sites in Saccharomyces cerevisiae.Mechanisms for enzymatic cleavage of the N-glycosidic bond in DNA.Uracil-DNA glycosylases-structural and functional perspectives on an essential family of DNA repair enzymes.
P2860
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P2860
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase
description
1996 nî lūn-bûn
@nan
1996 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase
@ast
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase
@en
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase
@nl
type
label
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase
@ast
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase
@en
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase
@nl
prefLabel
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase
@ast
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase
@en
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase
@nl
P2093
P2860
P1433
P1476
Excision of cytosine and thymine from DNA by mutants of human uracil-DNA glycosylase
@en
P2093
P2860
P304
P407
P577
1996-07-01T00:00:00Z