Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat
about
Molecular cloning, expression and catalytic activity of a human AKR7 member of the aldo-keto reductase superfamily: evidence that the major 2-carboxybenzaldehyde reductase from human liver is a homologue of rat aflatoxin B1-aldehyde reductaseNAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis. Isolation, characterization and biochemical properties of the enzymeCrystal structure of CHO reductase, a member of the aldo-keto reductase superfamilyInhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: role of Trp112 (Trp111)Kinetics and crystallographic analysis of human glutathione reductase in complex with a xanthene inhibitorStudies on the inhibitor-binding site of porcine aldehyde reductase: crystal structure of the holoenzyme-inhibitor ternary complexComparative anatomy of the aldo-keto reductase superfamilyAFAP-120. A variant form of the Src SH2/SH3-binding partner AFAP-110 is detected in brain and contains a novel internal sequence which binds to a 67-kDa protein.Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes.Aldose reductase-catalyzed reduction of aldehyde phospholipidsAldose Reductase Acts as a Selective Derepressor of PPARγ and the Retinoic Acid Receptor.Path-integral method for predicting relative binding affinities of protein-ligand complexes.Advance in dietary polyphenols as aldose reductases inhibitors: structure-activity relationship aspect.Structural basis for 18-β-glycyrrhetinic acid as a novel non-GSH analog glyoxalase I inhibitor.Identification of amino acid residues responsible for differences in substrate specificity and inhibitor sensitivity between two human liver dihydrodiol dehydrogenase isoenzymes by site-directed mutagenesisKinetic alteration of a human dihydrodiol/3alpha-hydroxysteroid dehydrogenase isoenzyme, AKR1C4, by replacement of histidine-216 with tyrosine or phenylalanine.Roles of the C-terminal domains of human dihydrodiol dehydrogenase isoforms in the binding of substrates and modulators: probing with chimaeric enzymes.Characterization of homogeneous recombinant rat ovarian 20alpha-hydroxysteroid dehydrogenase: fluorescent properties and inhibition profile.Crystal structure of an aldehyde reductase Y50F mutant-NADP complex and its implications for substrate binding.Purification, molecular cloning, and catalytic activity of Schizosaccharomyces pombe pyridoxal reductase. A possible additional family in the aldo-keto reductase superfamily.The aldo-keto reductase superfamily and its role in drug metabolism and detoxificationDetermination of relative binding affinities of labeling molecules with amino acids by using scanning tunneling microscopy
P2860
Q24313464-838D34A3-DD64-48C9-AF74-6D585A050544Q24530335-EC0074EE-7899-4510-AA9A-5378DDB4A2EDQ27621079-34D7EF70-E39A-4FD6-9D1E-9EAC2209B434Q27686951-F23790D9-DB05-4D62-A1D1-536D28AB04E9Q27732688-02052038-6040-493D-9512-BF60BE04453FQ27745686-E35CEC5F-EA86-4E5A-9C32-ECD8D56EDE64Q30043211-EED27DF0-F516-4119-9AAF-3FF52867A66BQ30193637-30AD017C-3999-44EB-807B-0DB0BDA336BDQ35669992-A3CBBBF5-F7EE-4931-83BE-A7DFA015792DQ36330024-0DB6CB02-44C1-4637-96FD-42262B1D566EQ36784506-D24DA207-7147-4140-816A-E1902EDF22CEQ37166094-CB2E271E-30FA-4A55-8196-C2B8587BBF16Q38238178-EB654E2B-4A06-4D22-98EC-64FD4D935E47Q42005470-D712CF50-1942-4EAA-B7EF-7AD7391B9B24Q42132854-0F1AB72C-F69A-4C64-BEFE-0BC75A82F46BQ42158145-E10ED2FF-9C87-4D6D-BD22-621796D04222Q42159054-0F621E39-E50E-47AF-91DF-512CF0ED0C2DQ42994272-DA7B18DE-8749-467A-8DF1-C4236E86101AQ43608572-22B05AA4-F763-4295-BB8C-268480302F58Q47940339-C63DB35B-3FBE-48FE-ADA2-DA227323F255Q56760512-B69062A2-B8E5-4518-952C-97B4E9E92B63Q58068006-71067778-9CF9-4D12-8DC4-245242D72316
P2860
Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat
description
1993 nî lūn-bûn
@nan
1993 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Refined 1.8 A structure of hum ...... e potent inhibitor zopolrestat
@ast
Refined 1.8 A structure of hum ...... e potent inhibitor zopolrestat
@en
Refined 1.8 A structure of hum ...... e potent inhibitor zopolrestat
@nl
type
label
Refined 1.8 A structure of hum ...... e potent inhibitor zopolrestat
@ast
Refined 1.8 A structure of hum ...... e potent inhibitor zopolrestat
@en
Refined 1.8 A structure of hum ...... e potent inhibitor zopolrestat
@nl
prefLabel
Refined 1.8 A structure of hum ...... e potent inhibitor zopolrestat
@ast
Refined 1.8 A structure of hum ...... e potent inhibitor zopolrestat
@en
Refined 1.8 A structure of hum ...... e potent inhibitor zopolrestat
@nl
P2093
P2860
P356
P1476
Refined 1.8 A structure of hum ...... e potent inhibitor zopolrestat
@en
P2093
D K Wilson
F A Quiocho
J M Petrash
P2860
P304
P356
10.1073/PNAS.90.21.9847
P407
P577
1993-11-01T00:00:00Z