Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression - Wikidata - thesis-toulmin - TriplyDB

Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression

Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression

http://www.wikidata.org/entity/Q24569635

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Centrosome dysfunction contributes to chromosome instability, chromoanagenesis, and genome reprograming in cancer Centriole assembly and the role of Mps1: defensible or dispensable?Polo-like kinase 4: the odd one out of the family Germline mutations in DIS3L2 cause the Perlman syndrome of overgrowth and Wilms tumor susceptibility PLK2 phosphorylation is critical for CPAP function in procentriole formation during the centrosome cycle MPS1-dependent mitotic BLM phosphorylation is important for chromosome stability Ab ovo or de novo? Mechanisms of centriole duplication The multiple roles of mps1 in Drosophila female meiosis Application of a new dual localization-affinity purification tag reveals novel aspects of protein kinase biology in Aspergillus nidulans Crystal structure of the catalytic domain of the mitotic checkpoint kinase Mps1 in complex with SP600125 Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function Chemical genetic inhibition of Mps1 in stable human cell lines reveals novel aspects of Mps1 function in mitosis The Sac3 homologue shd1 is involved in mitotic progression in mammalian cells Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint.Mob4 plays a role in spindle focusing in Drosophila S2 cells.High levels of the Mps1 checkpoint protein are protective of aneuploidy in breast cancer cells.Characterization of novel MPS1 inhibitors with preclinical anticancer activity The complement of protein kinases of the microsporidium Encephalitozoon cuniculi in relation to those of Saccharomyces cerevisiae and Schizosaccharomyces pombe Using cell fate attractors to uncover transcriptional regulation of HL60 neutrophil differentiation.Mutational analysis of TTK gene in gastric and colorectal cancers with microsatellite instability.The MPS1 family of protein kinases.Autophosphorylation of polo-like kinase 4 and its role in centriole duplication Angelman syndrome protein UBE3A interacts with primary microcephaly protein ASPM, localizes to centrosomes and regulates chromosome segregation Formation of extra centrosomal structures is dependent on beta-catenin.Regulation of spindle pole body assembly and cytokinesis by the centrin-binding protein Sfi1 in fission yeast.Degradation of the human mitotic checkpoint kinase Mps1 is cell cycle-regulated by APC-cCdc20 and APC-cCdh1 ubiquitin ligases.The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2 VDAC3 regulates centriole assembly by targeting Mps1 to centrosomes.Antizyme restrains centrosome amplification by regulating the accumulation of Mps1 at centrosomes VDAC3 and Mps1 negatively regulate ciliogenesis.TTK kinase is essential for the centrosomal localization of TACC2.Cellular abundance of Mps1 and the role of its carboxyl terminal tail in substrate recruitment.TTK/hMps1 participates in the regulation of DNA damage checkpoint response by phosphorylating CHK2 on threonine 68.Mps1 phosphorylation sites regulate the function of centrin 2 in centriole assembly.The G1 phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification.Physical and functional interaction between mortalin and Mps1 kinase.Mps1 activation loop autophosphorylation enhances kinase activity.Cdc14B depletion leads to centriole amplification, and its overexpression prevents unscheduled centriole duplication.CDC25B overexpression stabilises centrin 2 and promotes the formation of excess centriolar foci Impaired Bub1 function in vivo compromises tension-dependent checkpoint function leading to aneuploidy and tumorigenesis.

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Human Mps1 protein kinase is required for centrosome duplication and normal mitotic progression

http://www.wikidata.org/entity/Q24569635

description

2003 nî lūn-bûn

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2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

@zh-hk

2003年論文

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2003年論文

@zh-tw

2003年论文

@wuu

name

Human Mps1 protein kinase is r ...... and normal mitotic progression

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Human Mps1 protein kinase is r ...... and normal mitotic progression

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Human Mps1 protein kinase is r ...... and normal mitotic progression

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type

label

Human Mps1 protein kinase is r ...... and normal mitotic progression

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Human Mps1 protein kinase is r ...... and normal mitotic progression

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Human Mps1 protein kinase is r ...... and normal mitotic progression

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prefLabel

Human Mps1 protein kinase is r ...... and normal mitotic progression

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Human Mps1 protein kinase is r ...... and normal mitotic progression

@en

Human Mps1 protein kinase is r ...... and normal mitotic progression

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PNAS.2434156100

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Proceedings of the National Academy of Sciences of the United States of America

P1476

Human Mps1 protein kinase is r ...... and normal mitotic progression

@en

P2093

Christopher P Mattison

http://www.w3.org/2001/XMLSchema#string

Harold A Fisk

http://www.w3.org/2001/XMLSchema#string

Mark Winey

http://www.w3.org/2001/XMLSchema#string

P2860

Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication

Expression of TTK, a novel human protein kinase, is associated with cell proliferation

CP110, a cell cycle-dependent CDK substrate, regulates centrosome duplication in human cells

Yeast spindle pole body duplication gene MPS1 encodes an essential dual specificity protein kinase

Human Mps1 kinase is required for the spindle assembly checkpoint but not for centrosome duplication

Human MPS1 kinase is required for mitotic arrest induced by the loss of CENP-E from kinetochores

Activation of the budding yeast spindle assembly checkpoint without mitotic spindle disruption.

S. cerevisiae genes required for cell cycle arrest in response to loss of microtubule function.

MPS1 and MPS2: novel yeast genes defining distinct steps of spindle pole body duplication.

The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint.

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scholarly article

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10.1073/PNAS.2434156100

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25

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100

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299837

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