Interleukin-15 biology and its therapeutic implications in cancer - Wikidata - thesis-toulmin - TriplyDB

Interleukin-15 biology and its therapeutic implications in cancer

Interleukin-15 biology and its therapeutic implications in cancer

http://www.wikidata.org/entity/Q24595605

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Splicing Regulation of Pro-Inflammatory Cytokines and Chemokines: At the Interface of the Neuroendocrine and Immune Systems Immunotherapy of Childhood Sarcomas Interleukin-7 and interleukin-15 for cancer Insufficient natural killer cell responses against retroviruses: how to improve NK cell killing of retrovirus-infected cells Targeting Strategies for Renal Cell Carcinoma: From Renal Cancer Cells to Renal Cancer Stem Cells Mechanism of Action of IL-7 and Its Potential Applications and Limitations in Cancer Immunotherapy IL15 and T-cell Stemness in T-cell-Based Cancer Immunotherapy The shared and contrasting roles of IL2 and IL15 in the life and death of normal and neoplastic lymphocytes: implications for cancer therapy Therapeutic cancer vaccines and combination immunotherapies involving vaccination Intramuscular delivery of heterodimeric IL-15 DNA in macaques produces systemic levels of bioactive cytokine inducing proliferation of NK and T cells The Concise Guide to PHARMACOLOGY 2013/14: catalytic receptors.Enriched environment reduces glioma growth through immune and non-immune mechanisms in mice The High Mobility Group A1 (HMGA1) Transcriptome in Cancer and Development.The role of inflammatory and anti-inflammatory cytokines in the pathogenesis of osteoarthritis.Expanded Human Blood-Derived γδT Cells Display Potent Antigen-Presentation Functions.Cytokine and cytokine receptor genes of the adaptive immune response are differentially associated with breast cancer risk in American women of African and European ancestry Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity Engineering anti-GD2 monoclonal antibodies for cancer immunotherapy.Increased antitumor effects using IL-2 with anti-TGF-β reveals competition between mouse NK and CD8 T cells.GD2-targeted immunotherapy and radioimmunotherapy Physiopathology of necrobiotic xanthogranuloma with monoclonal gammopathy.Eradicating HIV-1 infection: seeking to clear a persistent pathogen.Neuroblastoma: developmental biology, cancer genomics and immunotherapy.Interleukin-15 is required for immunosurveillance and immunoprevention of HER2/neu-driven mammary carcinogenesis.In Vivo Activation of Human NK Cells by Treatment with an Interleukin-15 Superagonist Potently Inhibits Acute In Vivo HIV-1 Infection in Humanized Mice Therapeutic cancer vaccines: current status and moving forward.IL-15 Superagonist Expands mCD8+ T, NK and NKT Cells after Burn Injury but Fails to Improve Outcome during Burn Wound Infection IL-15 suppresses colitis-associated colon carcinogenesis by inducing antitumor immunity.Soluble mediators of inflammation in HIV and their implications for therapeutics and vaccine development Metabolic regulation of organelle homeostasis in lupus T cells IL-15 regulates migration, invasion, angiogenesis and genes associated with lipid metabolism and inflammation in prostate cancer.Targeted cancer immunotherapy: Mimicking physiological trans-presentation of IL-15 Common gamma chain cytokines in combinatorial immune strategies against cancer Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors.CD4(+) T-cell subsets and host defense in the lung Configuration-dependent Presentation of Multivalent IL-15:IL-15Rα Enhances the Antigen-specific T Cell Response and Anti-tumor Immunity Local Immune Stimulation by Intravesical Instillation of Baculovirus to Enable Bladder Cancer Therapy.Interleukin-15 enhances the proliferation, stimulatory phenotype, and antitumor effector functions of human gamma delta T cells IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction Antitumor activity of an immunocytokine composed of an anti-GD2 antibody and the IL-15 superagonist RLI.

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Interleukin-15 biology and its therapeutic implications in cancer

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Trends in Pharmacological Sciences

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Interleukin-15 biology and its therapeutic implications in cancer

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Jason C Steel

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John C Morris

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Thomas A Waldmann

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Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes

Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor

Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor

Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's

IL-15 triggers an antiapoptotic pathway in human intraepithelial lymphocytes that is a potential new target in celiac disease-associated inflammation and lymphomagenesis

IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T cells

Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides

Targeting the interleukin-15/interleukin-15 receptor system in inflammatory autoimmune diseases

Sipuleucel-T immunotherapy for castration-resistant prostate cancer

Improved Survival with Ipilimumab in Patients with Metastatic Melanoma

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