The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
about
Update in lung cancer and mesothelioma 2012Dynamic interplay between adhesion surfaces in carcinomas: Cell-cell and cell-matrix crosstalkTargeted therapies in development for non-small cell lung cancerNovel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPasesROS-induced epithelial-mesenchymal transition in mammary epithelial cells is mediated by NF-kB-dependent activation of Snail.Polyisoprenylated cysteinyl amide inhibitors disrupt actin cytoskeleton organization, induce cell rounding and block migration of non-small cell lung cancer.Tumor cell-derived MMP3 orchestrates Rac1b and tissue alterations that promote pancreatic adenocarcinoma.Sema3C promotes the survival and tumorigenicity of glioma stem cells through Rac1 activation.Oncogenic suppression of apoptosis uncovers a Rac1/JNK proliferation pathway activated by loss of Par3.Loss of RhoA Exacerbates, Rather Than Dampens, Oncogenic K-Ras Induced Lung Adenoma Formation in Mice.RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies.Tumor cell expression of MMP3 as a prognostic factor for poor survival in pancreatic, pulmonary, and mammary carcinomaGenome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events.Ibuprofen inhibits colitis-induced overexpression of tumor-related Rac1bExtending the Impact of RAC1b Overexpression to Follicular Thyroid CarcinomasROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation.Deregulation of Rho GTPases in cancerDistinct transcriptional changes in non-small cell lung cancer patients associated with multi-antigenic RNActive® CV9201 immunotherapy.TIPE2 suppresses angiogenesis and non-small cell lung cancer (NSCLC) invasiveness via inhibiting Rac1 activation and VEGF expression.Phosphorylation of SRSF1 by SRPK1 regulates alternative splicing of tumor-related Rac1b in colorectal cells.Rho GTPases modulate malignant transformation of tumor cells.Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signallingNotch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53Deregulation of splicing factors and breast cancer development.Rho GTPases: Anti- or pro-neoplastic targets?The role of TGF-β and its crosstalk with RAC1/RAC1b signaling in breast and pancreas carcinoma.Rac1b enhances cell survival through activation of the JNK2/c-JUN/Cyclin-D1 and AKT2/MCL1 pathways.Rac1 in human diseases: The therapeutic potential of targeting Rac1 signaling regulatory mechanisms.The role of small GTPases of the Rho/Rac family in TGF-β-induced EMT and cell motility in cancer.Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors.Emerging roles of RAC1 in treating lung cancer patients.Insufficient ability of Rac1b to perturb cystogenesis.A network-based analysis of colon cancer splicing changes reveals a tumorigenesis-favoring regulatory pathway emanating from ELK1MiR-622 inhibited colorectal cancer occurrence and metastasis by suppressing K-Ras.Identification of recurrent regulated alternative splicing events across human solid tumors.Rho GTPases: Regulation and roles in cancer cell biology.SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling.Alternative-splicing defects in cancer: Splicing regulators and their downstream targets, guiding the way to novel cancer therapeutics.Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase
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P2860
The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
description
2013 nî lūn-bûn
@nan
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
@ast
The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
@en
The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
@nl
type
label
The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
@ast
The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
@en
The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
@nl
prefLabel
The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
@ast
The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
@en
The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
@nl
P2093
P2860
P3181
P356
P1433
P1476
The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis
@en
P2093
A V Kossenkov
J L Kissil
S Licciulli
P2860
P2888
P3181
P356
10.1038/ONC.2012.99
P407
P577
2013-02-14T00:00:00Z
P5875
P6179
1007786392