Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma - Wikidata - thesis-toulmin - TriplyDB

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

http://www.wikidata.org/entity/Q24600346

about

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule Blockade of XBP1 splicing by inhibition of IRE1α is a promising therapeutic option in multiple myeloma Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing The Role of Organelle Stresses in Diabetes Mellitus and Obesity: Implication for Treatment Cancer Microenvironment and Endoplasmic Reticulum Stress Response Endoplasmic Reticulum Stress in the Diabetic Kidney, the Good, the Bad and the Ugly Drugging the unfolded protein response in acute leukemias DangER: protein ovERload. Targeting protein degradation to treat myeloma Xenobiotic perturbation of ER stress and the unfolded protein response Protein homeostasis as a therapeutic target for diseases of protein conformation Crosstalk between the unfolded protein response and NF-κB-mediated inflammation in the progression of chronic kidney disease Novel therapeutic strategies for multiple myeloma Tumor progression and the different faces of the PERK kinase Molecular Pathways: Immunosuppressive Roles of IRE1α-XBP1 Signaling in Dendritic Cells of the Tumor Microenvironment X-box binding protein 1 (XBP1s) is a critical determinant of Pseudomonas aeruginosa homoserine lactone-mediated apoptosis Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer The unfolded protein response in immunity and inflammation The unfolded protein response: from stress pathway to homeostatic regulation Molecular mechanisms of human IRE1 activation through dimerization and ligand binding Expression of inositol-requiring enzyme 1β is downregulated in colorectal cancer Synthesis of novel tricyclic chromenone-based inhibitors of IRE-1 RNase activity.Thioredoxin-interacting protein links endoplasmic reticulum stress to inflammatory brain injury and apoptosis after subarachnoid haemorrhage.Mechanistic rationale for targeting the unfolded protein response in pre-B acute lymphoblastic leukemia.Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease.ER stress, autophagy, and RNA viruses.Endoplasmic reticulum stress and cancer.Dinaciclib (SCH727965) inhibits the unfolded protein response through a CDK1- and 5-dependent mechanism ER stress activates NF-κB by integrating functions of basal IKK activity, IRE1 and PERK.A multiepitope of XBP1, CD138 and CS1 peptides induces myeloma-specific cytotoxic T lymphocytes in T cells of smoldering myeloma patients Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress.Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response.Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death.Identification and validation of novel PERK inhibitors.GCN5 inhibits XBP-1S-mediated transcription by antagonizing PCAF action Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.The unfolded protein response is shaped by the NMD pathway An unexpected alliance between stress responses to drive oncogenesis.Cleavage of BLOC1S1 mRNA by IRE1 Is Sequence Specific, Temporally Separate from XBP1 Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress Assay strategies for identification of therapeutic leads that target protein trafficking

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Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

http://www.wikidata.org/entity/Q24600346

description

2011 nî lūn-bûn

@nan

2011 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2011 թվականի հունվարին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Identification of an Ire1alpha ...... against human multiple myeloma

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Identification of an Ire1alpha ...... against human multiple myeloma

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Identification of an Ire1alpha ...... against human multiple myeloma

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type

label

Identification of an Ire1alpha ...... against human multiple myeloma

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Identification of an Ire1alpha ...... against human multiple myeloma

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Identification of an Ire1alpha ...... against human multiple myeloma

@nl

prefLabel

Identification of an Ire1alpha ...... against human multiple myeloma

@ast

Identification of an Ire1alpha ...... against human multiple myeloma

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Identification of an Ire1alpha ...... against human multiple myeloma

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Identification of an Ire1alpha ...... against human multiple myeloma

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Albert C Koong

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Arvin Tam

http://www.w3.org/2001/XMLSchema#string

David E Solow-Cordero

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Donna M Bouley

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Fritz Offner

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Heleen Van Melckebeke

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Ioanna Papandreou

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Maho Niwa

http://www.w3.org/2001/XMLSchema#string

Michael Olson

http://www.w3.org/2001/XMLSchema#string

Nicholas C Denko

http://www.w3.org/2001/XMLSchema#string

P2860

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

Basis for regulated RNA cleavage by functional analysis of RNase L and Ire1p

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

The unfolded protein response signals through high-order assembly of Ire1

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

Proteasome inhibitors disrupt the unfolded protein response in myeloma cells

Bortezomib (Velcadetrade mark) in the Treatment of Multiple Myeloma

IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates.

Heat shock protein inhibition is associated with activation of the unfolded protein response pathway in myeloma plasma cells.

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth.

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