The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury
about
Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitorsCathepsin B is a New Drug Target for Traumatic Brain Injury Therapeutics: Evidence for E64d as a Promising Lead Drug CandidateBrain pyroglutamate amyloid-β is produced by cathepsin B and is reduced by the cysteine protease inhibitor E64d, representing a potential Alzheimer's disease therapeuticDaily supplementation with GrandFusion® improves memory and learning in aged ratsDual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injuryGenetic and pharmacological evidence implicates cathepsins in Niemann-Pick C cerebellar degeneration.Degradomics in Neurotrauma: Profiling Traumatic Brain Injury.Insights from molecular modeling into the selective inhibition of cathepsin S by its inhibitor.Peptide Pharmacological Approaches to Treating Traumatic Brain Injury: a Case for Arginine-Rich Peptides.Cystatin C has a dual role in post-traumatic brain injury recovery.Microwave & magnetic proteomics of macrophages from patients with HIV-associated cognitive impairment.Aβ42-mediated proteasome inhibition and associated tau pathology in hippocampus are governed by a lysosomal response involving cathepsin B: Evidence for protective crosstalk between protein clearance pathways.Aβ Peptide Originated from Platelets Promises New Strategy in Anti-Alzheimer's Drug Development.Dysfunction of Membrane Trafficking Leads to Ischemia-Reperfusion Injury After Transient Cerebral Ischemia.Dietary supplementation of GrandFusion(®) mitigates cerebral ischemia-induced neuronal damage and attenuates inflammation.The Neuroprotection of Lysosomotropic Agents in Experimental Subarachnoid Hemorrhage Probably Involving the Apoptosis Pathway Triggering by Cathepsins via Chelating Intralysosomal Iron.Potential Alzheimer's Disease Therapeutics Among Weak Cysteine Protease Inhibitors Exhibit Mechanistic Differences Regarding Extent of Cathepsin B Up-Regulation and Ability to Block Calpain.Impact of nutrition on inflammation, tauopathy, and behavioral outcomes from chronic traumatic encephalopathy
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P2860
The cysteine protease cathepsin B is a key drug target and cysteine protease inhibitors are potential therapeutics for traumatic brain injury
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2014年の論文
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The cysteine protease cathepsi ...... ics for traumatic brain injury
@ast
The cysteine protease cathepsi ...... ics for traumatic brain injury
@en
The cysteine protease cathepsi ...... ics for traumatic brain injury
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The cysteine protease cathepsi ...... ics for traumatic brain injury
@ast
The cysteine protease cathepsi ...... ics for traumatic brain injury
@en
The cysteine protease cathepsi ...... ics for traumatic brain injury
@nl
prefLabel
The cysteine protease cathepsi ...... ics for traumatic brain injury
@ast
The cysteine protease cathepsi ...... ics for traumatic brain injury
@en
The cysteine protease cathepsi ...... ics for traumatic brain injury
@nl
P2093
P2860
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P1476
The cysteine protease cathepsi ...... ics for traumatic brain injury
@en
P2093
Gregory R Hook
Mark S Kindy
Michael D Pierschbacher
Nancy Sipes
Vivian Hook
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P304
P356
10.1089/NEU.2013.2944
P407
P577
2014-03-01T00:00:00Z