The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation
about
NatF contributes to an evolutionary shift in protein N-terminal acetylation and is important for normal chromosome segregationThe human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule PathwayN-terminal modifications of cellular proteins: The enzymes involved, their substrate specificities and biological effectsMolecular basis for N-terminal acetylation by the heterodimeric NatA complexProtein N-terminal acetyltransferases act as N-terminal propionyltransferases in vitro and in vivo.Biochemical and cellular analysis of Ogden syndrome reveals downstream Nt-acetylation defectsA splice donor mutation in NAA10 results in the dysregulation of the retinoic acid signalling pathway and causes Lenz microphthalmia syndromeProteome-derived peptide libraries allow detailed analysis of the substrate specificities of N(alpha)-acetyltransferases and point to hNaa10p as the post-translational actin N(alpha)-acetyltransferaseBiochemical evidence for relaxed substrate specificity of Nα-acetyltransferase (Rv3420c/rimI) of Mycobacterium tuberculosisThe biological functions of Naa10 - From amino-terminal acetylation to human diseaseAn Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril FormationPerturbation of the yeast N-acetyltransferase NatB induces elevation of protein phosphorylation levelsT-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1.Protein N-terminal acetyltransferases in cancer.Identification of HYPK-interacting proteins reveals involvement of HYPK in regulating cell growth, cell cycle, unfolded protein response and cell death.New roles for old modifications: emerging roles of N-terminal post-translational modifications in development and disease.Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes.Gap1 functions as a molecular chaperone to stabilize its interactive partner Gap3 during biogenesis of serine-rich repeat bacterial adhesinAbsence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms.N-terminal acetylation promotes synaptonemal complex assembly in C. elegans.Transcription regulation of HYPK by Heat Shock Factor 1Targeted large-scale analysis of protein acetylation.Faithful chaperones.Protein alpha-N-acetylation studied by N-terminomics.Polyglutamine Aggregation in Huntington Disease: Does Structure Determine Toxicity?Conserved C-terminal nascent peptide binding domain of HYPK facilitates its chaperone-like activity.SILProNAQ: A Convenient Approach for Proteome-Wide Analysis of Protein N-Termini and N-Terminal Acetylation Quantitation.The N-terminal acetyltransferase Naa10 is essential for zebrafish development.The Aggregation of Huntingtin and α-Synuclein.Structural basis of HypK regulating N-terminal acetylation by the NatA complex.Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae.Minimotifs dysfunction is pervasive in neurodegenerative disorders
P2860
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P2860
The chaperone-like protein HYPK acts together with NatA in cotranslational N-terminal acetylation and prevention of Huntingtin aggregation
description
2010 nî lūn-bûn
@nan
2010 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The chaperone-like protein HYP ...... tion of Huntingtin aggregation
@ast
The chaperone-like protein HYP ...... tion of Huntingtin aggregation
@en
The chaperone-like protein HYP ...... tion of Huntingtin aggregation
@nl
type
label
The chaperone-like protein HYP ...... tion of Huntingtin aggregation
@ast
The chaperone-like protein HYP ...... tion of Huntingtin aggregation
@en
The chaperone-like protein HYP ...... tion of Huntingtin aggregation
@nl
prefLabel
The chaperone-like protein HYP ...... tion of Huntingtin aggregation
@ast
The chaperone-like protein HYP ...... tion of Huntingtin aggregation
@en
The chaperone-like protein HYP ...... tion of Huntingtin aggregation
@nl
P2093
P2860
P50
P3181
P356
P1476
The chaperone-like protein HYP ...... tion of Huntingtin aggregation
@en
P2093
Anita Ryningen
Dave Anderson
Huyen Dinh
P2860
P304
P3181
P356
10.1128/MCB.01199-09
P407
P50
P577
2010-04-01T00:00:00Z