Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis - Wikidata - thesis-toulmin - TriplyDB

Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis

Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis

http://www.wikidata.org/entity/Q24606228

about

Emergence of multidrug-resistant, extensively drug-resistant and untreatable gonorrhea Ribosomal Antibiotics: Contemporary Challenges A New, Potent, and Placenta-Permeable Macrolide Antibiotic, Solithromycin, for the Prevention and Treatment of Bacterial Infections in Pregnancy Current and future antimicrobial treatment of gonorrhoea - the rapidly evolving Neisseria gonorrhoeae continues to challenge A dynamic structural model of expanded RNA CAG repeats: a refined X-ray structure and computational investigations using molecular dynamics and umbrella sampling simulations.Molecular basis for erythromycin-dependent ribosome stalling during translation of the ErmBL leader peptide Targeting Antibiotic Resistance Impact of ribosomal modification on the binding of the antibiotic telithromycin using a combined grand canonical monte carlo/molecular dynamics simulation approach Synthetic biology approaches to fluorinated polyketides Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways.In vitro activity of the new fluoroketolide solithromycin (CEM-101) against macrolide-resistant and -susceptible Mycoplasma genitalium strains.Critical 23S rRNA interactions for macrolide-dependent ribosome stalling on the ErmCL nascent peptide chain.The evolving role of chemical synthesis in antibacterial drug discovery.Newer antibacterials in therapy and clinical trials Determination of the secondary structure of group II bulge loops using the fluorescent probe 2-aminopurine.In vitro and in vivo activity of solithromycin (CEM-101) against Plasmodium species Combining structure probing data on RNA mutants with evolutionary information reveals RNA-binding interfaces.A platform for the discovery of new macrolide antibiotics.Precursor directed biosynthesis of an orthogonally functional erythromycin analogue: selectivity in the ribosome macrolide binding pocket A novel macrolide/fluoroketolide, solithromycin (CEM-101), reverses corticosteroid insensitivity via phosphoinositide 3-kinase pathway inhibition Maternal administration of solithromycin, a new, potent, broad-spectrum fluoroketolide antibiotic, achieves fetal and intra-amniotic antimicrobial protection in a pregnant sheep model.Azithromycin resistance is coevolving with reduced susceptibility to cephalosporins in Neisseria gonorrhoeae in Ontario, Canada.A Phase 2 Trial of Oral Solithromycin 1200 mg or 1000 mg as Single-Dose Oral Therapy for Uncomplicated Gonorrhea.On the specificity of antibiotics targeting the large ribosomal subunit.Macrolide antibiotics in the ribosome exit tunnel: species-specific binding and action.Antibiotics in development targeting protein synthesis.New antibacterial agents: patent applications published in 2010.The design of novel classes of macrolides for neutrophil-dominated inflammatory diseases.Renaissance of antibiotics against difficult infections: Focus on oritavancin and new ketolides and quinolones.The role of solithromycin in the management of bacterial community-acquired pneumonia.Toward the rational design of macrolide antibiotics to combat resistance.Antimicrobial-resistant sexually transmitted infections: gonorrhoea and Mycoplasma genitalium.Solithromycin (CEM-101): A New Fluoroketolide Antibiotic and Its Role in the Treatment of Gonorrhea.Macrolide resistance mechanisms in Enterobacteriaceae: Focus on azithromycin.Ribosome-Templated Azide-Alkyne Cycloadditions: Synthesis of Potent Macrolide Antibiotics by In Situ Click Chemistry.Resistance to Macrolide Antibiotics in Public Health Pathogens.Recent Advances in the Rational Design and Optimization of Antibacterial Agents.Nature nurtures the design of new semi-synthetic macrolide antibiotics.Solithromycin: A Novel Fluoroketolide for the Treatment of Community-Acquired Bacterial Pneumonia.The structural modification of natural products for novel drug discovery.

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Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis

http://www.wikidata.org/entity/Q24606228

description

2010 nî lūn-bûn

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2010 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Antimicrobial Agents and Chemotherapy

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Binding and action of CEM-101, ...... hat inhibits protein synthesis

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Alexander S Mankin

http://www.w3.org/2001/XMLSchema#string

Beatriz Llano-Sotelo

http://www.w3.org/2001/XMLSchema#string

Dorota Klepacki

http://www.w3.org/2001/XMLSchema#string

Jack Dunkle

http://www.w3.org/2001/XMLSchema#string

Jamie H D Cate

http://www.w3.org/2001/XMLSchema#string

Prabhavathi Fernandes

http://www.w3.org/2001/XMLSchema#string

Wen Zhang

http://www.w3.org/2001/XMLSchema#string

P2860

In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms

PHENIX: a comprehensive Python-based system for macromolecular structure solution

Structural basis for the antibiotic activity of ketolides and azalides

Structural Insight into the Antibiotic Action of Telithromycin against Resistant Mutants

Structures of the ribosome in intermediate states of ratcheting

Structures of the Escherichia coli ribosome with antibiotics bound near the peptidyl transferase center explain spectra of drug action

Coot: model-building tools for molecular graphics

Structures of the bacterial ribosome at 3.5 A resolution

Whole genome sequencing of meticillin-resistant Staphylococcus aureus

A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre.

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scholarly article

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10.1128/AAC.00860-10

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12

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54

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20855725

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2981243

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