Many local motions cooperate to produce the adenylate kinase conformational transition
about
Allosteric activation transitions in enzymes and biomolecular motors: insights from atomistic and coarse-grained simulationsExploring the conformational transitions of biomolecular systems using a simple two-state anisotropic network modelCrystal structure of shrimp arginine kinase in binary complex with arginine-a molecular view of the phosphagen precursor binding to the enzymeBinding leverage as a molecular basis for allosteric regulationInterconversion of functional motions between mesophilic and thermophilic adenylate kinasesFrustration, specific sequence dependence, and nonlinearity in large-amplitude fluctuations of allosteric proteins.Event detection and sub-state discovery from biomolecular simulations using higher-order statistics: application to enzyme adenylate kinase.WEBnm@ v2.0: Web server and services for comparing protein flexibilityClustENM: ENM-Based Sampling of Essential Conformational Space at Full Atomic Resolution.Discriminating binding mechanisms of an intrinsically disordered protein via a multi-state coarse-grained model.In silico elucidation of the recognition dynamics of ubiquitinBoth protein dynamics and ligand concentration can shift the binding mechanism between conformational selection and induced fitExploration of multi-state conformational dynamics and underlying global functional landscape of maltose binding protein.On the roles of substrate binding and hinge unfolding in conformational changes of adenylate kinase.In the multi-domain protein adenylate kinase, domain insertion facilitates cooperative folding while accommodating function at domain interfaces.X-ray solution scattering studies of the structural diversity intrinsic to protein ensemblesEnergetics and structural characterization of the large-scale functional motion of adenylate kinaseStatistical allosteric coupling to the active site indole ring flip equilibria in the FK506-binding domain.Reticular dysgenesis-associated AK2 protects hematopoietic stem and progenitor cell development from oxidative stress.Structural distributions from single-molecule measurements as a tool for molecular mechanics.Large-scale motions in the adenylate kinase solution ensemble: coarse-grained simulations and comparison with solution X-ray scattering.Mapping the Dynamics Landscape of Conformational Transitions in Enzyme: The Adenylate Kinase Case.Biomolecular dynamics: order-disorder transitions and energy landscapesConformational heterogeneity within the LID domain mediates substrate binding to Escherichia coli adenylate kinase: function follows fluctuations.Flexible receptor docking for drug discovery.Enhanced conformational sampling technique provides an energy landscape view of large-scale protein conformational transitions.Protein folding pathways and state transitions described by classical equations of motion of an elastic network model.Coarse-grained simulations of protein-protein association: an energy landscape perspective.Global transitions of proteins explored by a multiscale hybrid methodology: application to adenylate kinase.Molecular dynamics studies on the conformational transitions of adenylate kinase: a computational evidence for the conformational selection mechanism.Synchronous opening and closing motions are essential for cAMP-dependent protein kinase A signaling.Combined effect of confinement and affinity of crowded environment on conformation switching of adenylate kinase.Fine structure of conformational ensembles in adenylate kinase.Tracking the Catalytic Cycle of Adenylate Kinase by Ultraviolet Photodissociation Mass Spectrometry.Molecular dynamics simulations on the conformational transitions from the GA 98 (GA 88) to GB 98 (GB 88) proteins.Opening mechanism of adenylate kinase can vary according to selected molecular dynamics force field.Sampling large conformational transitions: adenylate kinase as a testing ground
P2860
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P2860
Many local motions cooperate to produce the adenylate kinase conformational transition
description
2010 nî lūn-bûn
@nan
2010 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Many local motions cooperate to produce the adenylate kinase conformational transition
@ast
Many local motions cooperate to produce the adenylate kinase conformational transition
@en
Many local motions cooperate to produce the adenylate kinase conformational transition
@nl
type
label
Many local motions cooperate to produce the adenylate kinase conformational transition
@ast
Many local motions cooperate to produce the adenylate kinase conformational transition
@en
Many local motions cooperate to produce the adenylate kinase conformational transition
@nl
prefLabel
Many local motions cooperate to produce the adenylate kinase conformational transition
@ast
Many local motions cooperate to produce the adenylate kinase conformational transition
@en
Many local motions cooperate to produce the adenylate kinase conformational transition
@nl
P2093
P2860
P1476
Many local motions cooperate to produce the adenylate kinase conformational transition
@en
P2093
George N Phillips
Michael D Daily
P2860
P304
P356
10.1016/J.JMB.2010.05.015
P407
P577
2010-07-16T00:00:00Z