TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival
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The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexesRegulation of TopBP1 oligomerization by Akt/PKB for cell survivalMCPH1/BRIT1 cooperates with E2F1 in the activation of checkpoint, DNA repair and apoptosisRegulation of E2F1 function by the nuclear corepressor KAP1The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcriptionClaspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activationTo live or let die - complexity within the E2F1 pathwayThe Prohibitins: emerging roles in diverse functionsSAF-A forms a complex with BRG1 and both components are required for RNA polymerase II mediated transcriptionE2F1-Mediated Induction of NFYB Attenuates Apoptosis via Joint Regulation of a Pro-Survival Transcriptional ProgramMolecular signatures of quiescent, mobilized and leukemia-initiating hematopoietic stem cells.E2F3 is a mediator of DNA damage-induced apoptosis.E2F1 localizes to sites of UV-induced DNA damage to enhance nucleotide excision repair.Regulation of E2F1-induced apoptosis by the nucleolar protein RRP1BE2F-1 directly regulates thrombospondin 1 expression.14-3-3Tau regulates Beclin 1 and is required for autophagy.E2F1 promotes the recruitment of DNA repair factors to sites of DNA double-strand breaksLens fiber cell differentiation and denucleation are disrupted through expression of the N-terminal nuclear receptor box of NCOA6 and result in p53-dependent and p53-independent apoptosis.Brg-1 mediates the constitutive and fenretinide-induced expression of SPARC in mammary carcinoma cells via its interaction with transcription factor Sp1.DNA damage signals through differentially modified E2F1 molecules to induce apoptosis.BRG1 co-localizes with DNA replication factors and is required for efficient replication fork progressionNovel link between E2F1 and Smac/DIABLO: proapoptotic Smac/DIABLO is transcriptionally upregulated by E2F1.TopBP1 deficiency causes an early embryonic lethality and induces cellular senescence in primary cellsTargeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapyDirect control of cell cycle gene expression by proto-oncogene product ACTR, and its autoregulation underlies its transforming activity.An essential function for the ATR-activation-domain (AAD) of TopBP1 in mouse development and cellular senescence.pVHL acts as a downstream target of E2F1 to suppress E2F1 activity.TOPBP1 recruits TOP2A to ultra-fine anaphase bridges to aid in their resolution.Nuclear localization of γ-tubulin affects E2F transcriptional activity and S-phase progressionTopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.High levels of TopBP1 induce ATR-dependent shut-down of rRNA transcription and nucleolar segregation.The E2F family: specific functions and overlapping interestsExpression of TopBP1 in hereditary breast cancerE2F1 and p53 transcription factors as accessory factors for nucleotide excision repair.An interaction between human papillomavirus 16 E2 and TopBP1 is required for optimum viral DNA replication and episomal genome establishmentLife and death decisions by the E2F transcription factors.Transcriptional and nontranscriptional functions of E2F1 in response to DNA damage.Characterization of conserved arginine residues on Cdt1 that affect licensing activity and interaction with Geminin or Mcm complex.E2F-associated chromatin modifiers and cell cycle controlBrg1 Enables Rapid Growth of the Early Embryo by Suppressing Genes That Regulate Apoptosis and Cell Growth Arrest.
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P2860
TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival
description
2004 nî lūn-bûn
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2004 թուականի Մարտին հրատարակուած գիտական յօդուած
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2004 թվականի մարտին հրատարակված գիտական հոդված
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2004年の論文
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2004年論文
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2004年論文
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2004年論文
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2004年論文
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2004年論文
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2004年论文
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TopBP1 recruits Brg1/Brm to re ...... ific control for cell survival
@ast
TopBP1 recruits Brg1/Brm to re ...... ific control for cell survival
@en
TopBP1 recruits Brg1/Brm to re ...... ific control for cell survival
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TopBP1 recruits Brg1/Brm to re ...... ific control for cell survival
@ast
TopBP1 recruits Brg1/Brm to re ...... ific control for cell survival
@en
TopBP1 recruits Brg1/Brm to re ...... ific control for cell survival
@nl
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TopBP1 recruits Brg1/Brm to re ...... ific control for cell survival
@ast
TopBP1 recruits Brg1/Brm to re ...... ific control for cell survival
@en
TopBP1 recruits Brg1/Brm to re ...... ific control for cell survival
@nl
P2093
P2860
P3181
P356
P1433
P1476
TopBP1 recruits Brg1/Brm to re ...... ific control for cell survival
@en
P2093
Fang-Tsyr Lin
Weei-Chin Lin
Yuhong Luo
P2860
P304
P3181
P356
10.1101/GAD.1180204
P407
P577
2004-03-15T00:00:00Z