Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons - Wikidata - thesis-toulmin - TriplyDB

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

http://www.wikidata.org/entity/Q24628425

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Functional interaction of Parkinson's disease-associated LRRK2 with members of the dynamin GTPase superfamily Adult hippocampal neurogenesis in Parkinson's disease: impact on neuronal survival and plasticity Upstream deregulation of calcium signaling in Parkinson's disease After the banquet: mitochondrial biogenesis, mitophagy, and cell survival Progressive dopaminergic alterations and mitochondrial abnormalities in LRRK2 G2019S knock-in mice It's a cell-eat-cell world: autophagy and phagocytosis.Dysregulation of autophagy and mitochondrial function in Parkinson's disease Organelle-Specific Sensors for Monitoring Ca2+ Dynamics in Neurons Human Atg8-cardiolipin interactions in mitophagy: Specific properties of LC3B, GABARAPL2 and GABARAP Functional and Morphological Correlates in the Drosophila LRRK2 loss-of-function Model of Parkinson's Disease: Drug Effects of Withania somnifera (Dunal) Administration ERKed by LRRK2: a cell biological perspective on hereditary and sporadic Parkinson's disease.Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A Discovering New Genes in the Pathways of Common Sporadic Neurodegenerative Diseases: A Bioinformatics Approach.Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration.The Docosanoid Neuroprotectin D1 Induces TH-Positive Neuronal Survival in a Cellular Model of Parkinson's Disease Understanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson's disease.Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation.Molecular events underlying Parkinson's disease - an interwoven tapestry.Melatonin attenuates MPTP-induced neurotoxicity via preventing CDK5-mediated autophagy and SNCA/α-synuclein aggregation.LRRK2: an éminence grise of Wnt-mediated neurogenesis?Autophagy in axonal and dendritic degeneration.Metallomic Biomarkers in Cerebrospinal fluid and Serum in patients with Parkinson's disease in Indian population.Oxidative stress mechanisms underlying Parkinson's disease-associated neurodegeneration in C. elegans.Leucine-Rich Repeat Kinase 2 (Lrrk2)-Sensitive Na+/K+ ATPase Activity in Dendritic Cells Insights into mitochondrial quality control pathways and Parkinson's disease.Does restraining nitric oxide biosynthesis rescue from toxins-induced parkinsonism and sporadic Parkinson's disease?Targeting leucine-rich repeat kinase 2 in Parkinson's disease.The centrality of mitochondria in the pathogenesis and treatment of Parkinson's disease.Calcium signaling in Parkinson's disease.A mitocentric view of Parkinson's disease.LRRK2, a puzzling protein: insights into Parkinson's disease pathogenesis Defective autophagy in Parkinson's disease: lessons from genetics.Cellular processes associated with LRRK2 function and dysfunction Alterations in late endocytic trafficking related to the pathobiology of LRRK2-linked Parkinson's disease.Genes associated with Parkinson's disease: regulation of autophagy and beyond.Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes.LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson's Disease.Mitochondria and Synaptic Plasticity in the Mature and Aging Nervous System.PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons

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P2860

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

http://www.wikidata.org/entity/Q24628425

description

2013 nî lūn-bûn

@nan

2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի փետրվարին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年論文

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2013年论文

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name

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

@ast

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

@en

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

@nl

type

label

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

@ast

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

@en

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

@nl

prefLabel

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

@ast

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

@en

Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

@nl

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J.AJPATH.2012.10.027

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The American Journal of Pathology

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Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons

@en

P2093

Aaron M Gusdon

http://www.w3.org/2001/XMLSchema#string

Erin Steer

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Kirill Kiselyov

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Salvatore J Cherra

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P2860

Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

Guidelines for the use and interpretation of assays for monitoring autophagy

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

LRRK2 controls synaptic vesicle storage and mobilization within the recycling pool

Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression

Leucine-rich repeat kinase 2 regulates autophagy through a calcium-dependent pathway involving NAADP

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

Rac1 protein rescues neurite retraction caused by G2019S leucine-rich repeat kinase 2 (LRRK2)

LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: impairment of the kinase activity by Parkinson's disease-associated mutations

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

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474-484

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1420102

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10.1016/J.AJPATH.2012.10.027

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2

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182

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Charleen T. Chu

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233900436

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23231918

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