Exploring protein fitness landscapes by directed evolution
about
Predictability of evolutionary trajectories in fitness landscapesQuantifying the adaptive potential of an antibiotic resistance enzymeExperimental illumination of a fitness landscapeIn vitro evolution goes deepRational Protein Engineering Guided by Deep Mutational ScanningReprogramming cells with synthetic proteinsShedding light on protein folding, structural and functional dynamics by single molecule studiesBridging scales in cancer progression: mapping genotype to phenotype using neural networksBiophysical characterization of mutants ofBacillus subtilislipase evolved for thermostability: Factors contributing to increased activity retentionTolerance of the archaeal Sac7d scaffold protein to alternative library designs: characterization of anti-immunoglobulin G AffitinsA Promiscuous De Novo Retro-Aldolase Catalyzes Asymmetric Michael Additions via Schiff Base IntermediatesE Pluribus Unum: 50 Years of Research, Millions of Viruses, and One Goal--Tailored Acceleration of AAV EvolutionUsing simple donors to drive the equilibria of glycosyltransferase-catalyzed reactionsIn vivo continuous directed evolutionDirected evolution: tailoring biocatalysts for industrial applicationsAnalyzing protein structure and function using ancestral gene reconstructionPrevalence of epistasis in the evolution of influenza A surface proteinsBiochemical characterization of predicted Precambrian RuBisCOReverse evolution leads to genotypic incompatibility despite functional and active site convergenceFitness Trade-Offs Determine the Role of the Molecular Chaperonin GroEL in Buffering MutationsRefolding of a thermostable glyceraldehyde dehydrogenase for application in synthetic cascade biomanufacturingSynthetic biology of phenotypic adaptation in vertebrates: the next frontierExploiting genomic knowledge in optimising molecular breeding programmes: algorithms from evolutionary computingHighly regio- and enantioselective multiple oxy- and amino-functionalizations of alkenes by modular cascade biocatalysisThermal stability and kinetic constants for 129 variants of a family 1 glycoside hydrolase reveal that enzyme activity and stability can be separately designedHistorical contingency and its biophysical basis in glucocorticoid receptor evolution.The virtue of innovation: innovation through the lenses of biological evolutionEvolution of sparsity and modularity in a model of protein allostery.Improved de novo structure prediction in CASP11 by incorporating coevolution information into Rosetta.HotSpot Wizard 2.0: automated design of site-specific mutations and smart libraries in protein engineering.Molecular signatures-based prediction of enzyme promiscuity.Computational protein engineering: bridging the gap between rational design and laboratory evolution.Manipulation of enzyme properties by noncanonical amino acid incorporation.Controlling enzyme inhibition using an expanded set of genetically encoded amino acids.Engineering platforms for directed evolution of Laccase from Pycnoporus cinnabarinus.Directed evolution of a virus exclusively utilizing human epidermal growth factor receptor as the entry receptor.The quest for molecular quasi-species in ligand-activity space and its application to directed enzyme evolution.CyDNA: synthesis and replication of highly Cy-dye substituted DNA by an evolved polymerase.Simple, fast and high-efficiency transformation system for directed evolution of cellulase in Bacillus subtilis.Rapid generation of random mutant libraries.
P2860
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P2860
Exploring protein fitness landscapes by directed evolution
description
2009 nî lūn-bûn
@nan
2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Exploring protein fitness landscapes by directed evolution
@ast
Exploring protein fitness landscapes by directed evolution
@en
Exploring protein fitness landscapes by directed evolution
@nl
type
label
Exploring protein fitness landscapes by directed evolution
@ast
Exploring protein fitness landscapes by directed evolution
@en
Exploring protein fitness landscapes by directed evolution
@nl
prefLabel
Exploring protein fitness landscapes by directed evolution
@ast
Exploring protein fitness landscapes by directed evolution
@en
Exploring protein fitness landscapes by directed evolution
@nl
P2860
P921
P3181
P356
P1476
Exploring protein fitness landscapes by directed evolution
@en
P2093
Philip A Romero
P2860
P2888
P304
P3181
P356
10.1038/NRM2805
P407
P577
2009-12-01T00:00:00Z
P5875
P6179
1044846333