SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis
about
Transcriptional repression of mitochondrial function in aging: a novel role for the silencing mediator of retinoid and thyroid hormone receptors co-repressorGenomewide analyses define different modes of transcriptional regulation by peroxisome proliferator-activated receptor-β/δ (PPARβ/δ)HDAC2 phosphorylation-dependent Klf5 deacetylation and RARα acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCsDGAT enzymes are required for triacylglycerol synthesis and lipid droplets in adipocytesThyroid hormone receptor repression is linked to type I pneumocyte-associated respiratory distress syndromeRescue of a primary myelofibrosis model by retinoid-antagonist therapyDeciphering direct and indirect influence of thyroid hormone with mouse genetics.Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARgamma in obese mice and humansTranscriptional coregulators: fine-tuning metabolism.The silencing mediator of retinoid and thyroid hormone receptors (SMRT) regulates adipose tissue accumulation and adipocyte insulin sensitivity in vivoEarly B cell factor 1 regulates adipocyte morphology and lipolysis in white adipose tissue.Cellular retinol-binding protein type I (CRBP-I) regulates adipogenesis.The interaction between nuclear receptor corepressor and histone deacetylase 3 regulates both positive and negative thyroid hormone action in vivo.An emerging role for bromodomain-containing proteins in chromatin regulation and transcriptional control of adipogenesis.Elevated NCOR1 disrupts PPARalpha/gamma signaling in prostate cancer and forms a targetable epigenetic lesion.NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.Regulation of SMRT corepressor dimerization and composition by MAP kinase phosphorylation.Nuclear receptor corepressor SMRT regulates mitochondrial oxidative metabolism and mediates aging-related metabolic deteriorationCorepressor SMRT promotes oxidative phosphorylation in adipose tissue and protects against diet-induced obesity and insulin resistance.NCoR1 and SMRT play unique roles in thyroid hormone action in vivoThe optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor γ requires G protein pathway suppressor 2.Allele compensation in tip60+/- mice rescues white adipose tissue function in vivo.Alternative mRNA splicing of corepressors generates variants that play opposing roles in adipocyte differentiation.SMRTε, a corepressor variant, interacts with a restricted subset of nuclear receptors, including the retinoic acid receptors α and βA PPARγ-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis.The nuclear receptor corepressor (NCoR) controls thyroid hormone sensitivity and the set point of the hypothalamic-pituitary-thyroid axisNew targets to treat obesity and the metabolic syndrome.Adipose tissue signaling by nuclear receptors in metabolic complications of obesityTranscriptional Regulation by Nuclear Corepressors and PGC-1α: Implications for Mitochondrial Quality Control and Insulin Sensitivity.The in vivo role of nuclear receptor corepressors in thyroid hormone action.SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation.Nuclear receptor co-repressors are required for the histone-deacetylase activity of HDAC3 in vivo.Emerging roles of the corepressors NCoR1 and SMRT in homeostasis.New insights into the functions and regulation of the transcriptional corepressors SMRT and N-CoRDeacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor.Retinoic acid receptor modulators: a perspective on recent advances and promises.Epigenetic codes of PPARγ in metabolic disease.The epigenome and its role in diabetes.Context-dependent mechanisms modulating aldosterone signaling in the kidney.The actions of thyroid hormone signaling in the nucleus.
P2860
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P248
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P2860
SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis
description
2008 nî lūn-bûn
@nan
2008 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
SMRT repression of nuclear rec ...... oint and metabolic homeostasis
@ast
SMRT repression of nuclear rec ...... oint and metabolic homeostasis
@en
SMRT repression of nuclear rec ...... oint and metabolic homeostasis
@nl
type
label
SMRT repression of nuclear rec ...... oint and metabolic homeostasis
@ast
SMRT repression of nuclear rec ...... oint and metabolic homeostasis
@en
SMRT repression of nuclear rec ...... oint and metabolic homeostasis
@nl
prefLabel
SMRT repression of nuclear rec ...... oint and metabolic homeostasis
@ast
SMRT repression of nuclear rec ...... oint and metabolic homeostasis
@en
SMRT repression of nuclear rec ...... oint and metabolic homeostasis
@nl
P2093
P2860
P50
P356
P1476
SMRT repression of nuclear rec ...... oint and metabolic homeostasis
@en
P2093
Chih-Hao Lee
Grant D Barish
Liming Pei
Mathias Leblanc
Michael Downes
Michael Nelson
Russell R Nofsinger
Sheue-Yann Cheng
P2860
P304
P356
10.1073/PNAS.0811012105
P407
P577
2008-12-16T00:00:00Z