The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway
about
Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarityA novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPasesRad GTPase deficiency leads to cardiac hypertrophyPhosphorylation of critical serine residues in Gem separates cytoskeletal reorganization from down-regulation of calcium channel activityRegulation of RhoA-dependent ROCKII activation by Shp2Regulation of voltage-gated calcium channel activity by the Rem and Rad GTPasesRho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapyRhoE binds to ROCK I and inhibits downstream signalingExpression, purification, crystallization and preliminary crystallographic analysis of human Rad GTPaseRegulation of ROCK activity in cancerActivity-dependent subcellular cotrafficking of the small GTPase Rem2 and Ca2+/CaM-dependent protein kinase IIαStructure of the GDP-bound G domain of the RGK protein Rem2Active gene repression by the Egr2.NAB complex during peripheral nerve myelinationN-cadherin regulates spatially polarized signals through distinct p120ctn and β-catenin-dependent signalling pathways.Yolk syncytial layer formation is a failure of cytokinesis mediated by Rock1 function in the early zebrafish embryo.GEF-H1 functions in apical constriction and cell intercalations and is essential for vertebrate neural tube closure.Dysregulated Glycoprotein B-Mediated Cell-Cell Fusion Disrupts Varicella-Zoster Virus and Host Gene Transcription during Infection.Identification of genes involved in cell invasion by using a library of randomized hybrid ribozymes.The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway.Rho kinase: an important mediator of atherosclerosis and vascular disease.Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions.Rem2-targeted shRNAs reduce frequency of miniature excitatory postsynaptic currents without altering voltage-gated Ca²⁺ currents.Ser1333 phosphorylation indicates ROCKI activation.Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handlingRho/Rho-associated coiled-coil forming kinase pathway as therapeutic targets for statins in atherosclerosis.Crystal structure of human Rad GTPase of the RGK-family.Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.High throughput transcriptome profiling of lithium stimulated human mesenchymal stem cells reveals priming towards osteoblastic lineage.Hepatocyte growth factor switches orientation of polarity and mode of movement during morphogenesis of multicellular epithelial structuresRho-associated coiled-coil-forming kinases (ROCKs): potential targets for the treatment of atherosclerosis and vascular disease.A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton.Gem-induced cytoskeleton remodeling increases cellular migration of HTLV-1-infected cells, formation of infected-to-target T-cell conjugates and viral transmission.Dual role for RhoA in suppression and induction of cytokines in the human neutrophil.Regulation of glucose transport by ROCK1 differs from that of ROCK2 and is controlled by actin polymerizationA collapsin response mediator protein 2 isoform controls myosin II-mediated cell migration and matrix assembly by trapping ROCK II.PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulationAnalysis of transcriptional responses in the mouse dorsal striatum following acute 3,4-methylenedioxymethamphetamine (ecstasy): identification of extracellular signal-regulated kinase-controlled genes.ROCKs as therapeutic targets in cardiovascular diseasesRho kinase as potential therapeutic target for cardiovascular diseases: opportunities and challenges.Dose-dependent and isoform-specific modulation of Ca2+ channels by RGK GTPases
P2860
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P2860
The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway
description
2002 nî lūn-bûn
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2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
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name
The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway
@ast
The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway
@en
The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway
@nl
type
label
The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway
@ast
The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway
@en
The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway
@nl
prefLabel
The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway
@ast
The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway
@en
The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway
@nl
P2093
P2860
P356
P1476
The GTP binding proteins Gem a ...... of the Rho-Rho kinase pathway
@en
P2093
Beth Spinelli
Fumio Matsumura
Kathleen Kelly
Masaaki Ito
Seow-Fong Yap
V Ravichandran
Yvona Ward
P2860
P304
P356
10.1083/JCB.200111026
P407
P577
2002-04-15T00:00:00Z