Protein kinase C iota: human oncogene, prognostic marker and therapeutic target - Wikidata - thesis-toulmin - TriplyDB

Protein kinase C iota: human oncogene, prognostic marker and therapeutic target

Protein kinase C iota: human oncogene, prognostic marker and therapeutic target

http://www.wikidata.org/entity/Q24652905

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Protein kinase C signaling and cell cycle regulation Chemoresistance and Cancer-Related Inflammation: Two Hallmarks of Cancer Connected by an Atypical Link, PKCζ An aPKC-exocyst complex controls paxillin phosphorylation and migration through localised JNK1 activation Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes The RNA binding protein FXR1 is a new driver in the 3q26-29 amplicon and predicts poor prognosis in human cancers The identification of protein kinase C iota as a regulator of the Mammalian heat shock response using functional genomic screens Knowledge-based fragment binding prediction Protein kinase C isoforms: Multi-functional regulators of cell life and death Overexpression of atypical protein kinase C in HeLa cells facilitates macropinocytosis via Src activation Coordination of glioblastoma cell motility by PKCι Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis Identification of candidate growth promoting genes in ovarian cancer through integrated copy number and expression analysis.Protein kinase C isoforms zeta and iota mediate collagenase expression and cartilage destruction via STAT3- and ERK-dependent c-fos induction PKCλ/ι signaling promotes triple-negative breast cancer growth and metastasis Transforming growth factor-β-inducible early response gene 1 is a novel substrate for atypical protein kinase Cs.Protein kinase Cα signaling regulates inhibitor of DNA binding 1 in the intestinal epithelium Diacylglycerol lactones targeting the structural features that distinguish the atypical C1 domains of protein kinase C ζ and ι from typical C1 domains.Keratins in health and cancer: more than mere epithelial cell markers Loss of the polarity protein PAR3 activates STAT3 signaling via an atypical protein kinase C (aPKC)/NF-κB/interleukin-6 (IL-6) axis in mouse mammary cells.PDK1 in apical signaling endosomes participates in the rescue of the polarity complex atypical PKC by intermediate filaments in intestinal epithelia.Protein kinase C iota as a therapeutic target in alveolar rhabdomyosarcoma.Wealth of opportunity - the C1 domain as a target for drug development.PKCζ Promotes Breast Cancer Invasion by Regulating Expression of E-cadherin and Zonula Occludens-1 (ZO-1) via NFκB-p65.Atypical PKC-iota Controls Stem Cell Expansion via Regulation of the Notch Pathway.PKC phosphorylates HEXIM1 and regulates P-TEFb activity.The chromosome 3q26 OncCassette: A multigenic driver of human cancer.Ceramide signaling in cancer and stem cells.Agonist-induced down-regulation of endogenous protein kinase c α through an endolysosomal mechanism.PKCiota promotes ovarian tumor progression through deregulation of cyclin E.Overview of cancer stem cells (CSCs) and mechanisms of their regulation: implications for cancer therapy.PTEN loss represses glioblastoma tumor initiating cell differentiation via inactivation of Lgl1.Par complex in cancer: a regulator of normal cell polarity joins the dark side.Matrix metalloproteinase-10 is a critical effector of protein kinase Ciota-Par6alpha-mediated lung cancer.PKCι regulates nuclear YAP1 localization and ovarian cancer tumorigenesis Targeting oncogenic protein kinase Cι for treatment of mutant KRAS LADC.Molecular targeted therapy in ovarian cancer: what is on the horizon?Protein kinase C in Wnt signaling: implications in cancer initiation and progression.Protein kinase C and its inhibitors in the regulation of inflammation: inducible nitric oxide synthase as an example.Glycogen Synthase Kinase 3β Is Positively Regulated by Protein Kinase Cζ-Mediated Phosphorylation Induced by Wnt Agonists Phorbol ester phorbol-12-myristate-13-acetate induces epithelial to mesenchymal transition in human prostate cancer ARCaPE cells.

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Protein kinase C iota: human oncogene, prognostic marker and therapeutic target

http://www.wikidata.org/entity/Q24652905

description

2007 nî lūn-bûn

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2007 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2007 թվականի հունիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Protein kinase C iota: human oncogene, prognostic marker and therapeutic target

@ast

Protein kinase C iota: human oncogene, prognostic marker and therapeutic target

@en

Protein kinase C iota: human oncogene, prognostic marker and therapeutic target

@nl

type

label

Protein kinase C iota: human oncogene, prognostic marker and therapeutic target

@ast

Protein kinase C iota: human oncogene, prognostic marker and therapeutic target

@en

Protein kinase C iota: human oncogene, prognostic marker and therapeutic target

@nl

prefLabel

Protein kinase C iota: human oncogene, prognostic marker and therapeutic target

@ast

Protein kinase C iota: human oncogene, prognostic marker and therapeutic target

@en

Protein kinase C iota: human oncogene, prognostic marker and therapeutic target

@nl

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J.PHRS.2007.04.015

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Pharmacological Research

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Protein kinase C iota: human oncogene, prognostic marker and therapeutic target

@en

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Alan P Fields

http://www.w3.org/2001/XMLSchema#string

Roderick P Regala

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P2860

The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation.

The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42

The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor

Atypical protein kinase C is involved in the evolutionarily conserved par protein complex and plays a critical role in establishing epithelia-specific junctional structures

Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C

Segregation of receptor and ligand regulates activation of epithelial growth factor receptor

Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62.

MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling

The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway

Nerve growth factor stimulates multisite tyrosine phosphorylation and activation of the atypical protein kinase C's via a src kinase pathway.

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487-97

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scholarly article

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10.1016/J.PHRS.2007.04.015

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6

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55

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17570678

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2705893

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