Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities
about
Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase in Trypanosoma brucei using chemical and genetic methodsChemical validation of trypanothione synthetase: a potential drug target for human trypanosomiasisRecent developments in drug discovery for leishmaniasis and human African trypanosomiasisStructural Basis of Murein Peptide Specificity of a γ-D-Glutamyl-L-Diamino Acid EndopeptidaseSpecificity and Mechanism ofAcinetobacter baumaniiNicotinamidase: Implications for Activation of the Front-Line Tuberculosis Drug PyrazinamideStructural Basis for Evolution of Product Diversity in Soybean Glutathione BiosynthesisStructure of Trypanosoma brucei glutathione synthetase: Domain and loop alterations in the catalytic cycle of a highly conserved enzymeProtein S-Thiolation by Glutathionylspermidine (Gsp): THE ROLE OF ESCHERICHIA COLI Gsp SYNTHETASE/AMIDASE IN REDOX REGULATIONStructure and mechanism ofEscherichia coliglutathionylspermidine amidase belonging to the family of cysteine; histidine-dependent amidohydrolases/peptidasesStructural basis for type VI secreted peptidoglycanDL-endopeptidase function, specificity and neutralization inSerratia marcescensStructures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophileRegulated expression of an essential allosteric activator of polyamine biosynthesis in African trypanosomesMathematical modelling of polyamine metabolism in bloodstream-form Trypanosoma brucei: an application to drug target identificationMolecular dynamics reveal binding mode of glutathionylspermidine by trypanothione synthetaseStructural and biochemical characterization reveals LysGH15 as an unprecedented "EF-hand-like" calcium-binding phage lysinStage-dependent expression and up-regulation of trypanothione synthetase in amphotericin B resistant Leishmania donovaniIdentification of Novel Chemical Scaffolds Inhibiting Trypanothione Synthetase from Pathogenic TrypanosomatidsPolyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilitiesGenetic validation of Trypanosoma brucei glutathione synthetase as an essential enzyme.Design, synthesis and biological evaluation of Trypanosoma brucei trypanothione synthetase inhibitors.RNA interference-mediated silencing of ornithine decarboxylase and spermidine synthase genes in Trypanosoma brucei provides insight into regulation of polyamine biosynthesis.Optimized CGenFF force-field parameters for acylphosphate and N-phosphonosulfonimidoyl functional groups.Polyamine metabolism in Leishmania: from arginine to trypanothione.Structural insights into the enzymes of the trypanothione pathway: targets for antileishmaniasis drugs.Polyamine-trypanothione pathway: an update.Stress-Induced Protein S-Glutathionylation and S-Trypanothionylation in African Trypanosomes-A Quantitative Redox Proteome and Thiol Analysis.An Improved Model of the Trypanosoma brucei CTP Synthetase Glutaminase Domain-Acivicin Complex.In-silico analyses of sesquiterpene-related compounds on selected Leishmania enzyme-based targets.Dissecting the catalytic mechanism of Trypanosoma brucei trypanothione synthetase by kinetic analysis and computational modelingATP-dependent ligases in trypanothione biosynthesis--kinetics of catalysis and inhibition by phosphinic acid pseudopeptides.Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani.Buthionine sulfoximine is a multitarget inhibitor of trypanothione synthesis in Trypanosoma cruzi.
P2860
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P2860
Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Leishmania trypanothione synth ...... etic and hydrolytic activities
@ast
Leishmania trypanothione synth ...... etic and hydrolytic activities
@en
Leishmania trypanothione synth ...... etic and hydrolytic activities
@nl
type
label
Leishmania trypanothione synth ...... etic and hydrolytic activities
@ast
Leishmania trypanothione synth ...... etic and hydrolytic activities
@en
Leishmania trypanothione synth ...... etic and hydrolytic activities
@nl
altLabel
Leishmania Trypanothione Synth ...... etic and Hydrolytic Activities
@en
prefLabel
Leishmania trypanothione synth ...... etic and hydrolytic activities
@ast
Leishmania trypanothione synth ...... etic and hydrolytic activities
@en
Leishmania trypanothione synth ...... etic and hydrolytic activities
@nl
P2860
P50
P356
P1476
Leishmania trypanothione synth ...... etic and hydrolytic activities
@en
P2093
Paul K Fyfe
P2860
P304
17672-17680
P356
10.1074/JBC.M801850200
P407
P577
2008-04-17T00:00:00Z