A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
about
Linking human diseases to animal models using ontology-based phenotype annotationRASopathies: unraveling mechanisms with animal modelsExpression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cellsThe intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathwayRas history: The saga continues.In vivo synaptic transmission and morphology in mouse models of Tuberous sclerosis, Fragile X syndrome, Neurofibromatosis type 1, and Costello syndromeConstitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome.Kinase-activating and kinase-impaired cardio-facio-cutaneous syndrome alleles have activity during zebrafish development and are sensitive to small molecule inhibitors.Ras in cancer and developmental diseasesVav3 is involved in GABAergic axon guidance events important for the proper function of brainstem neurons controlling cardiovascular, respiratory, and renal parameters.K-RasV14I recapitulates Noonan syndrome in mice.Fate and plasticity of the epidermis in response to congenital activation of BRAF.Transformation by Hras(G12V) is consistently associated with mutant allele copy gains and is reversed by farnesyl transferase inhibition.Mutant Hras(G12V) and Kras(G12D) have overlapping, but non-identical effects on hepatocyte growth and transformation frequency in transgenic miceActivated Kras alters epidermal homeostasis of mouse skin, resulting in redundant skin and defective hair cycling.Cardiomyopathies in Noonan syndrome and the other RASopathies.Modelling oncogenic Ras/Raf signalling in the mouse.A New View of Ras Isoforms in Cancers.Direct reprogramming by oncogenic Ras and Myc.Senescence in tumours: evidence from mice and humansThe renin-angiotensin system modulates inflammatory processes in atherosclerosis: evidence from basic research and clinical studiesEndogenous expression of Hras(G12V) induces developmental defects and neoplasms with copy number imbalances of the oncogeneIn vivo severity ranking of Ras pathway mutations associated with developmental disorders.Signaling to cardiac hypertrophy: insights from human and mouse RASopathies.Genetic pathways in disorders of epidermal differentiation.Genetic analysis of Ras genes in epidermal development and tumorigenesis.Thyroid C-Cell Biology and Oncogenic Transformation.The impact of the genetic background in the Noonan syndrome phenotype induced by K-Ras(V14I).HCN channels are a novel therapeutic target for cognitive dysfunction in Neurofibromatosis type 1.Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse modelsFunctional specificity of ras isoforms: so similar but so different.Enhanced human brain associative plasticity in Costello syndrome.Mice with an Oncogenic HRAS Mutation are Resistant to High-Fat Diet-Induced Obesity and Exhibit Impaired Hepatic Energy Homeostasis.Costello Syndrome: The Challenge of Hypoglycemia and Failure to Thrive.Transposon mutagenesis identifies chromatin modifiers cooperating with Ras in thyroid tumorigenesis and detects ATXN7 as a cancer gene.An attenuated phenotype of Costello syndrome in three unrelated individuals with a HRAS c.179G>A (p.Gly60Asp) mutation correlates with uncommon functional consequences.
P2860
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P2860
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
@ast
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
@en
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
@nl
type
label
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
@ast
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
@en
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
@nl
prefLabel
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
@ast
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
@en
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
@nl
P2860
P50
P356
P1476
A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition
@en
P2093
Marta Cañamero
Vincent Sauzeau
P2860
P304
P356
10.1172/JCI34385
P407
P577
2008-06-01T00:00:00Z