Roles of bioactive sphingolipids in cancer biology and therapeutics - Wikidata - thesis-toulmin - TriplyDB

Roles of bioactive sphingolipids in cancer biology and therapeutics

Roles of bioactive sphingolipids in cancer biology and therapeutics

http://www.wikidata.org/entity/Q24657499

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The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases Sphingosine 1-phosphate lyase, a key regulator of sphingosine 1-phosphate signaling and function Mammalian ceramide synthases A critical role for ceramide synthase 2 in liver homeostasis: II. insights into molecular changes leading to hepatopathy Autophagy paradox and ceramide Elisidepsin Interacts Directly with Glycosylceramides in the Plasma Membrane of Tumor Cells to Induce Necrotic Cell Death Ceramide transfer protein deficiency compromises organelle function and leads to senescence in primary cells The protein kinase Sch9 is a key regulator of sphingolipid metabolism in Saccharomyces cerevisiae.Ceramide induced mitophagy and tumor suppression Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer.Rational design for multifunctional non-liposomal lipid-based nanocarriers for cancer management: theory to practice.Lipid metabolism emerges as a promising target for malignant glioma therapy.The pleiotropic roles of sphingolipid signaling in autophagy A hypothesis concerning a potential involvement of ceramide in apoptosis and acantholysis induced by pemphigus autoantibodies.Ceramide modulates HERG potassium channel gating by translocation into lipid rafts Discovery and evaluation of inhibitors of human ceramidase.Inhibition of sphingosine kinase 2 downregulates the expression of c-Myc and Mcl-1 and induces apoptosis in multiple myeloma.Limonoid compounds inhibit sphingomyelin biosynthesis by preventing CERT protein-dependent extraction of ceramides from the endoplasmic reticulum.Gaucher's disease and cancer: a sphingolipid perspective Hyaluronic acid derivative-based self-assembled nanoparticles for the treatment of melanoma.Sphingosine kinase 1 is required for mesothelioma cell proliferation: role of histone acetylation.Apoptotic sphingolipid ceramide in cancer therapy.Ceramide kinase promotes tumor cell survival and mammary tumor recurrence.Regulation of cancer cell migration and invasion by sphingosine-1-phosphate Targeting NFĸB mediated breast cancer chemoresistance through selective inhibition of sphingosine kinase-2 The role of sphingosine kinase-1 in EGFRvIII-regulated growth and survival of glioblastoma cells Combined anticancer effects of sphingosine kinase inhibitors and sorafenib.Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: involvement of CB2 Genistein stimulates MCF-7 breast cancer cell growth by inducing acid ceramidase (ASAH1) gene expression.Acid ceramidase expression modulates the sensitivity of A375 melanoma cells to dacarbazine.Protein phosphatase 2A and neutral sphingomyelinase 2 regulate IRAK-1 protein ubiquitination and degradation in response to interleukin-1beta Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer.Biomarker identification and pathway analysis by serum metabolomics of lung cancer.Acid ceramidase (ASAH1) is a global regulator of steroidogenic capacity and adrenocortical gene expression Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma Tamoxifen augments the innate immune function of neutrophils through modulation of intracellular ceramide.2',4'-dihydroxychalcone, a flavonoid isolated from Herba oxytropis, suppresses PC-3 human prostate cancer cell growth by induction of apoptosis.Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression.Sphingosine kinase 1 is required for TGF-β mediated fibroblastto- myofibroblast differentiation in ovarian cancer.

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Roles of bioactive sphingolipids in cancer biology and therapeutics

http://www.wikidata.org/entity/Q24657499

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Roles of bioactive sphingolipids in cancer biology and therapeutics

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Roles of bioactive sphingolipids in cancer biology and therapeutics

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Roles of bioactive sphingolipids in cancer biology and therapeutics

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Roles of bioactive sphingolipids in cancer biology and therapeutics

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Roles of bioactive sphingolipids in cancer biology and therapeutics

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Roles of bioactive sphingolipids in cancer biology and therapeutics

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Roles of bioactive sphingolipids in cancer biology and therapeutics

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Sub-cellular biochemistry

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Roles of bioactive sphingolipids in cancer biology and therapeutics

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Besim Ogretmen

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Pengfei Song

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Sahar A Saddoughi

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Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization

Mammalian Lass6 and its related family members regulate synthesis of specific ceramides

Upstream of growth and differentiation factor 1 (uog1), a mammalian homolog of the yeast longevity assurance gene 1 (LAG1), regulates N-stearoyl-sphinganine (C18-(dihydro)ceramide) synthesis in a fumonisin B1-independent manner in mammalian cells

Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity

Molecular machinery for non-vesicular trafficking of ceramide

Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide

Mechanisms of ceramide-mediated repression of the human telomerase reverse transcriptase promoter via deacetylation of Sp3 by histone deacetylase 1

Sphingosine kinase type 1 promotes estrogen-dependent tumorigenesis of breast cancer MCF-7 cells

Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide

(Dihydro)ceramide synthase 1 regulated sensitivity to cisplatin is associated with the activation of p38 mitogen-activated protein kinase and is abrogated by sphingosine kinase 1

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