Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain - Wikidata - thesis-toulmin - TriplyDB

Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain

Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain

http://www.wikidata.org/entity/Q24658016

about

Dynamin GTPase regulation is altered by PH domain mutations found in centronuclear myopathy patients p63RhoGEF: a new switch for G(q)-mediated activation of smooth muscle.Function and regulation of the Rho guanine nucleotide exchange factor Trio Structure of Galphaq-p63RhoGEF-RhoA complex reveals a pathway for the activation of RhoA by GPCRs Structural diversity in the RGS domain and its interaction with heterotrimeric G protein -subunits Kinetic Scaffolding Mediated by a Phospholipase C- and Gq Signaling Complex Signaling efficiency of Gαq through its effectors p63RhoGEF and GEFT depends on their subcellular location Autoinhibition of GEF activity in Intersectin 1 is mediated by the short SH3-DH domain linker.Strike a pose: Gαq complexes at the membrane Elimination of Kalrn expression in POMC cells reduces anxiety-like behavior and contextual fear learning.p63RhoGEF couples Gα(q/11)-mediated signaling to Ca2+ sensitization of vascular smooth muscle contractility.On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.Kinetics of recruitment and allosteric activation of ARHGEF25 isoforms by the heterotrimeric G-protein Gαq Structure and function of heterotrimeric G protein-regulated Rho guanine nucleotide exchange factors.Galpha q allosterically activates and relieves autoinhibition of p63RhoGEF.Gα16 interacts with tetratricopeptide repeat 1 (TPR1) through its β3 region to activate Ras independently of phospholipase Cβ signaling Real-time visualization of heterotrimeric G protein Gq activation in living cells Evolution of a signaling nexus constrained by protein interfaces and conformational States.HCMV pUS28 initiates pro-migratory signaling via activation of Pyk2 kinase Identification of kalirin-7 as a potential post-synaptic density signaling hub UNC-73/trio RhoGEF-2 activity modulates Caenorhabditis elegans motility through changes in neurotransmitter signaling upstream of the GSA-1/Galphas pathway.Plasma membrane association of p63 Rho guanine nucleotide exchange factor (p63RhoGEF) is mediated by palmitoylation and is required for basal activity in cells Heterotrimeric G proteins, focal adhesion kinase, and endothelial barrier function.Protein kinase C (PKC)ζ-mediated Gαq stimulation of ERK5 protein pathway in cardiomyocytes and cardiac fibroblasts.Trio's Rho-specific GEF domain is the missing Galpha q effector in C. elegans Plasma membrane restricted RhoGEF activity is sufficient for RhoA-mediated actin polymerization.A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors.Mechanism of activation and inactivation of Gq/phospholipase C-β signaling nodes Protein kinase C-related kinase and ROCK are required for thrombin-induced endothelial cell permeability downstream from Galpha12/13 and Galpha11/q.MLK3 limits activated Galphaq signaling to Rho by binding to p63RhoGEF.A functional siRNA screen identifies genes modulating angiotensin II-mediated EGFR transactivation.Regulation and physiological functions of G12/13-mediated signaling pathways.Neuronal Rho GEFs in synaptic physiology and behavior.Synaptic plasticity, a symphony in GEF.Revisited and revised: is RhoA always a villain in cardiac pathophysiology?Signaling mechanisms that regulate smooth muscle cell differentiation.Pleckstrin homology (PH) like domains - versatile modules in protein-protein interaction platforms.The many faces of the guanine-nucleotide exchange factor trio.I'm coming to GEF you: Regulation of RhoGEFs during cell migration.Dynamics of Gαq-protein-p63RhoGEF interaction and its regulation by RGS2.

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P2860

Galphaq directly activates p63RhoGEF and Trio via a conserved extension of the Dbl homology-associated pleckstrin homology domain

http://www.wikidata.org/entity/Q24658016

description

2007 nî lūn-bûn

@nan

2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի հոտեմբերին հրատարակված գիտական հոդված

@hy

2007年の論文

@ja

2007年論文

@yue

2007年論文

@zh-hant

2007年論文

@zh-hk

2007年論文

@zh-mo

2007年論文

@zh-tw

2007年论文

@wuu

name

Galphaq directly activates p63 ...... ted pleckstrin homology domain

@ast

Galphaq directly activates p63 ...... ted pleckstrin homology domain

@en

Galphaq directly activates p63 ...... ted pleckstrin homology domain

@nl

type

label

Galphaq directly activates p63 ...... ted pleckstrin homology domain

@ast

Galphaq directly activates p63 ...... ted pleckstrin homology domain

@en

Galphaq directly activates p63 ...... ted pleckstrin homology domain

@nl

prefLabel

Galphaq directly activates p63 ...... ted pleckstrin homology domain

@ast

Galphaq directly activates p63 ...... ted pleckstrin homology domain

@en

Galphaq directly activates p63 ...... ted pleckstrin homology domain

@nl

P1433

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P2860

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P1433

Journal of Biological Chemistry

P1476

Galphaq directly activates p63 ...... ted pleckstrin homology domain

@en

P2093

Marielle E Yohe

http://www.w3.org/2001/XMLSchema#string

Rafael J Rojas

http://www.w3.org/2001/XMLSchema#string

Svetlana Gershburg

http://www.w3.org/2001/XMLSchema#string

Takeharu Kawano

http://www.w3.org/2001/XMLSchema#string

Tohru Kozasa

http://www.w3.org/2001/XMLSchema#string

P2860

Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein

The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools

A crystallographic view of interactions between Dbs and Cdc42: PH domain-assisted guanine nucleotide exchange.

Structural basis for the selective activation of Rho GTPases by Dbl exchange factors

The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac-specific and rho-specific guanine nucleotide exchange factor domains

beta-Arrestin 1 and Galphaq/11 coordinately activate RhoA and stress fiber formation following receptor stimulation

Modulation of muscle regeneration, myogenesis, and adipogenesis by the Rho family guanine nucleotide exchange factor GEFT.

ExPASy: The proteomics server for in-depth protein knowledge and analysis

The DH and PH domains of Trio coordinately engage Rho GTPases for their efficient activation

Basic local alignment search tool

P304

29201-10

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P31

scholarly article

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2590749

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P356

10.1074/JBC.M703458200

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P407

P433

40

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P478

282

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P50

P577

2007-10-05T00:00:00Z

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P5875

6230360

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P698

17606614

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P921

P932

2655113

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