GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast
about
A vertebrate gene, ticrr, is an essential checkpoint and replication regulatorPSF1 is essential for early embryogenesis in miceAncestral paralogs and pseudoparalogs and their role in the emergence of the eukaryotic cellDistinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forksIsolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicaseA requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replicationCDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol (epsilon}, and GINS in budding yeastThe replication fork: understanding the eukaryotic replication machinery and the challenges to genome duplicationHow do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?Activation of the DNA damage checkpoint in mutants defective in DNA replication initiationDomain architecture and biochemical characterization of vertebrate Mcm10DNA replication in the archaeaHuman Mcm10 regulates the catalytic subunit of DNA polymerase-alpha and prevents DNA damage during replicationMolecular architecture of the human GINS complex.Mcm10 and And-1/CTF4 recruit DNA polymerase alpha to chromatin for initiation of DNA replicationTackling an essential problem in functional proteomics of Saccharomyces cerevisiaeDNA binding and helicase actions of mouse MCM4/6/7 helicase.Evidence for interplay among yeast replicative DNA polymerases alpha, delta and epsilon from studies of exonuclease and polymerase active site mutationsNuclear distribution and chromatin association of DNA polymerase alpha-primase is affected by TEV protease cleavage of Cdc23 (Mcm10) in fission yeast.The Mcm2-7 replicative helicase: a promising chemotherapeutic targetLoading and activation of DNA replicative helicases: the key step of initiation of DNA replicationStructure of the human GINS complex and its assembly and functional interface in replication initiationCrystal structure of the human GINS complexCrystal structure of the GINS complex and functional insights into its role in DNA replicationStructure of the Cdt1 C-terminal domain: Conservation of the winged helix fold in replication licensing factorsArchitectures of archaeal GINS complexes, essential DNA replication initiation factorsA conserved MCM single-stranded DNA binding element is essential for replication initiationThe quaternary structure of the eukaryotic DNA replication proteins Sld7 and Sld3Atomic structure of an archaeal GAN suggests its dual roles as an exonuclease in DNA repair and a CMG component in DNA replicationBreak-induced replication requires all essential DNA replication factors except those specific for pre-RC assembly.Sld2 binds to origin single-stranded DNA and stimulates DNA annealing.Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.A CDK-catalysed regulatory phosphorylation for formation of the DNA replication complex Sld2-Dpb11The Rix1 (Ipi1p-2p-3p) complex is a critical determinant of DNA replication licensing independent of their roles in ribosome biogenesis.Efficient initiation of DNA replication in eukaryotes requires Dpb11/TopBP1-GINS interactionSld7, an Sld3-associated protein required for efficient chromosomal DNA replication in budding yeast.A conserved Hsp10-like domain in Mcm10 is required to stabilize the catalytic subunit of DNA polymerase-alpha in budding yeast.A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome.Ordered assembly of Sld3, GINS and Cdc45 is distinctly regulated by DDK and CDK for activation of replication origins.Double-stranded DNA binding properties of Saccharomyces cerevisiae DNA polymerase epsilon and of the Dpb3p-Dpb4p subassembly.
P2860
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P248
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P2860
GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast
description
2003 nî lūn-bûn
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2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2003 թվականի մայիսին հրատարակված գիտական հոդված
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2003年の論文
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2003年論文
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2003年論文
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2003年論文
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2003年論文
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2003年論文
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2003年论文
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name
GINS, a novel multiprotein com ...... A replication in budding yeast
@ast
GINS, a novel multiprotein com ...... A replication in budding yeast
@en
GINS, a novel multiprotein com ...... A replication in budding yeast
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label
GINS, a novel multiprotein com ...... A replication in budding yeast
@ast
GINS, a novel multiprotein com ...... A replication in budding yeast
@en
GINS, a novel multiprotein com ...... A replication in budding yeast
@nl
prefLabel
GINS, a novel multiprotein com ...... A replication in budding yeast
@ast
GINS, a novel multiprotein com ...... A replication in budding yeast
@en
GINS, a novel multiprotein com ...... A replication in budding yeast
@nl
P2093
P2860
P3181
P356
P1433
P1476
GINS, a novel multiprotein com ...... A replication in budding yeast
@en
P2093
Akio Sugino
Hiroyuki Araki
Mariko Okawa
Sachiko Muramatsu
Yoichiro Kamimura
Yuko Takayama
P2860
P304
P3181
P356
10.1101/GAD.1065903
P407
P577
2003-05-01T00:00:00Z