Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro - Wikidata - thesis-toulmin - TriplyDB

Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro

Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro

http://www.wikidata.org/entity/Q24673383

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Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol Chemical probes of endocannabinoid metabolism Monoacylglycerol lipase - a target for drug development?Enzymatic pathways that regulate endocannabinoid signaling in the nervous system Chemoselective Synthesis of Carbamates using CO2 as Carbon Source.Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol.Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay.Increasing 2-arachidonoyl glycerol signaling in the periphery attenuates mechanical hyperalgesia in a model of bone cancer pain.Selective monoacylglycerol lipase inhibitors: antinociceptive versus cannabimimetic effects in mice Refined homology model of monoacylglycerol lipase: toward a selective inhibitor.Characterization of the effects of reuptake and hydrolysis inhibition on interstitial endocannabinoid levels in the brain: an in vivo microdialysis study Inhibition of 2-arachidonoylglycerol catabolism modulates vasoconstriction of rat middle cerebral artery by the thromboxane mimetic, U-46619.Microglia produce and hydrolyze palmitoylethanolamide.Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain.The monoacylglycerol lipase inhibitor JZL184 attenuates LPS-induced increases in cytokine expression in the rat frontal cortex and plasma: differential mechanisms of action The complications of promiscuity: endocannabinoid action and metabolism Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors.A novel monoacylglycerol lipase inhibitor with analgesic and anti-inflammatory activity The monoacylglycerol lipase inhibitor JZL184 suppresses inflammatory pain in the mouse carrageenan model.Pharmacological enhancement of endocannabinoid signaling reduces the cholinergic toxicity of diisopropylfluorophosphate.Targeting the endocannabinoid system: to enhance or reduce?Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond.Blockade of endocannabinoid-degrading enzymes attenuates neuropathic pain.Endocannabinoid-mediated control of synaptic transmission.Blockade of 2-arachidonoylglycerol hydrolysis by selective monoacylglycerol lipase inhibitor 4-nitrophenyl 4-(dibenzo[d][1,3]dioxol-5-yl(hydroxy)methyl)piperidine-1-carboxylate (JZL184) Enhances retrograde endocannabinoid signaling Dynamic regulation of the endocannabinoid system: implications for analgesia.Chemical modulation of glycerolipid signaling and metabolic pathways.Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain.The cannabinoid system and pain.2-Arachidonoylglycerol endocannabinoid signaling coupled to metabotropic glutamate receptor type-5 modulates anxiety-like behavior in the rat ventromedial prefrontal cortex.Modulation of the anti-nociceptive effects of 2-arachidonoyl glycerol by peripherally administered FAAH and MGL inhibitors in a neuropathic pain model.Monoglyceride lipase deficiency causes desensitization of intestinal cannabinoid receptor type 1 and increased colonic μ-opioid receptor sensitivity.Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease.Distribution and function of monoacylglycerol lipase in the gastrointestinal tract.Monoacylglycerol signalling and ABHD6 in health and disease.Conformational transition pathway in the inhibitor binding process of human monoacylglycerol lipase.Neuroprotective Effects of MAGL (Monoacylglycerol Lipase) Inhibitors in Experimental Ischemic Stroke.

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P2860

Lack of selectivity of URB602 for 2-oleoylglycerol compared to anandamide hydrolysis in vitro

http://www.wikidata.org/entity/Q24673383

description

2007 nî lūn-bûn

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2007 թուականի Յունուարին հրատարակուած գիտական յօդուած

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2007 թվականի հունվարին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Lack of selectivity of URB602 ...... anandamide hydrolysis in vitro

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Lack of selectivity of URB602 ...... anandamide hydrolysis in vitro

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Lack of selectivity of URB602 ...... anandamide hydrolysis in vitro

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type

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Lack of selectivity of URB602 ...... anandamide hydrolysis in vitro

@ast

Lack of selectivity of URB602 ...... anandamide hydrolysis in vitro

@en

Lack of selectivity of URB602 ...... anandamide hydrolysis in vitro

@nl

prefLabel

Lack of selectivity of URB602 ...... anandamide hydrolysis in vitro

@ast

Lack of selectivity of URB602 ...... anandamide hydrolysis in vitro

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Lack of selectivity of URB602 ...... anandamide hydrolysis in vitro

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British Journal of Pharmacology

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Lack of selectivity of URB602 ...... anandamide hydrolysis in vitro

@en

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C J Fowler

http://www.w3.org/2001/XMLSchema#string

D M Lambert

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E Persson

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G Labar

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K-O Jonsson

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S Vandevoorde

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P2860

Brain monoglyceride lipase participating in endocannabinoid inactivation

Human neuropathy target esterase catalyzes hydrolysis of membrane lipids

Purification and some properties of a monoacylglycerol-hydrolyzing enzyme of rat adipose tissue

URB754 has no effect on the hydrolysis or signaling capacity of 2-AG in the rat brain

Selective inhibition of 2-AG hydrolysis enhances endocannabinoid signaling in hippocampus

Effects of homologues and analogues of palmitoylethanolamide upon the inactivation of the endocannabinoid anandamide

MuLK, a eukaryotic multi-substrate lipid kinase

Modulation of anxiety through blockade of anandamide hydrolysis

An endocannabinoid mechanism for stress-induced analgesia.

Actions of the FAAH inhibitor URB597 in neuropathic and inflammatory chronic pain models.

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10.1038/SJ.BJP.0706971

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150

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