SB-334867-A: the first selective orexin-1 receptor antagonist - Wikidata - thesis-toulmin - TriplyDB

SB-334867-A: the first selective orexin-1 receptor antagonist

SB-334867-A: the first selective orexin-1 receptor antagonist

http://www.wikidata.org/entity/Q24674074

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Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far Orexin receptors: pharmacology and therapeutic opportunities Orexin/hypocretin and histamine: distinct roles in the control of wakefulness demonstrated using knock-out mouse models Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor Physiology of the orexinergic/hypocretinergic system: a revisit in 2012 Obesity pharmacotherapy: current perspectives and future directions The hypocretins/orexins: integrators of multiple physiological functions Orexin antagonists for neuropsychiatric disease: progress and potential pitfalls Multiple roles for orexin/hypocretin in addiction Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone The role of brain somatostatin receptor 2 in the regulation of feeding and drinking behavior The SK-N-MC cell line expresses an orexin binding site different from recombinant orexin 1-type receptor Structure-activity relationship of imidazopyridinium analogues as antagonists of neuropeptide s receptor Mechanism for Hypocretin-mediated sleep-to-wake transitions.Substituted tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor.LSN2424100: a novel, potent orexin-2 receptor antagonist with selectivity over orexin-1 receptors and activity in an animal model predictive of antidepressant-like efficacy.Food-induced expression of orexin receptors in rat duodenal mucosa regulates the bicarbonate secretory response to orexin-A.Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons.Orexin-driven GAD65 network of the lateral hypothalamus sets physical activity in mice.Origin of secretin receptor precedes the advent of tetrapoda: evidence on the separated origins of secretin and orexin Orexin-1 receptor mediates the increased food and water intake induced by intracerebroventricular injection of the stable somatostatin pan-agonist, ODT8-SST in rats.Orexin A induces GnRH gene expression and secretion from GT1-7 hypothalamic GnRH neurons.Anterior thalamic paraventricular nucleus is involved in intermittent access ethanol drinking: role of orexin receptor 2.Orexin A activates hypoglossal motoneurons and enhances genioglossus muscle activity in rats.Discrete cue-conditioned alcohol-seeking after protracted abstinence: pattern of neural activation and involvement of orexin₁ receptors.Involvement of the orexin/hypocretin system in ethanol conditioned place preference Antagonism of orexin 1 receptors eliminates motor hyperactivity and improves homing response acquisition in juvenile rats exposed to alcohol during early postnatal period.Diaryl urea analogues of SB-334867 as orexin-1 receptor antagonists.Functions of the orexinergic/hypocretinergic system.Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor.A selective orexin-1 receptor antagonist attenuates stress-induced hyperarousal without hypnotic effects Orexin-a modulates firing of rat rostral ventromedial medulla neurons: an in vitro study Effect of 1-substitution on tetrahydroisoquinolines as selective antagonists for the orexin-1 receptor Orexin-1 receptor signaling increases motivation for cocaine-associated cues An orexinergic projection from perifornical hypothalamus to raphe pallidus increases rat brown adipose tissue thermogenesis.Orexins/hypocretins act in the posterior paraventricular thalamic nucleus during repeated stress to regulate facilitation to novel stress.Orexin / hypocretin 1 receptor antagonist reduces heroin self-administration and cue-induced heroin seeking.The importance of the 6- and 7-positions of tetrahydroisoquinolines as selective antagonists for the orexin 1 receptor.Chemistry and biology of orexin signaling.Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists.

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SB-334867-A: the first selective orexin-1 receptor antagonist

http://www.wikidata.org/entity/Q24674074

description

2001 nî lūn-bûn

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2001 թուականի Մարտին հրատարակուած գիտական յօդուած

@hyw

2001 թվականի մարտին հրատարակված գիտական հոդված

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2001年の論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年論文

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2001年论文

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name

SB-334867-A: the first selective orexin-1 receptor antagonist

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SB-334867-A: the first selective orexin-1 receptor antagonist

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SB-334867-A: the first selective orexin-1 receptor antagonist

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type

label

SB-334867-A: the first selective orexin-1 receptor antagonist

@ast

SB-334867-A: the first selective orexin-1 receptor antagonist

@en

SB-334867-A: the first selective orexin-1 receptor antagonist

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prefLabel

SB-334867-A: the first selective orexin-1 receptor antagonist

@ast

SB-334867-A: the first selective orexin-1 receptor antagonist

@en

SB-334867-A: the first selective orexin-1 receptor antagonist

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British Journal of Pharmacology

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SB-334867-A: the first selective orexin-1 receptor antagonist

@en

P2093

A Johns

http://www.w3.org/2001/XMLSchema#string

C Sabido-David

http://www.w3.org/2001/XMLSchema#string

D Smart

http://www.w3.org/2001/XMLSchema#string

F Jewitt

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J C Jerman

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R A Porter

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S J Brough

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P2860

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

Characterization of recombinant human orexin receptor pharmacology in a Chinese hamster ovary cell-line using FLIPR

Neurons containing hypocretin (orexin) project to multiple neuronal systems

The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats.

Presynaptic and postsynaptic actions and modulation of neuroendocrine neurons by a new hypothalamic peptide, hypocretin/orexin.

Hypothalamic hypocretin (orexin): robust innervation of the spinal cord.

Orexins suppress catecholamine synthesis and secretion in cultured PC12 cells.

The hypocretins are weak agonists at recombinant human orexin-1 and orexin-2 receptors

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1179-82

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scholarly article

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3815106

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10.1038/SJ.BJP.0703953

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6

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132

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2001-03-01T00:00:00Z

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12081348

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11250867

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1572677

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