Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control - Wikidata - thesis-toulmin - TriplyDB

Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control

Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control

http://www.wikidata.org/entity/Q24679076

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FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways Autophagy signal transduction by ATG proteins: from hierarchies to networks HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of s6 kinase activation and cell growth Computational modeling and analysis of insulin induced eukaryotic translation initiation Preparation of mouse monoclonal antibody for RB1CC1 and its clinical application WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.The association of AMPK with ULK1 regulates autophagy.RB1CC1 together with RB1 and p53 predicts long-term survival in Japanese breast cancer patients TOR-dependent control of autophagy: biting the hand that feeds Downregulation of FIP200 induces apoptosis of glioblastoma cells and microvascular endothelial cells by enhancing Pyk2 activity.The COP1 E3-ligase interacts with FIP200, a key regulator of mammalian autophagy.Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis RB1CC1 protein suppresses type II collagen synthesis in chondrocytes and causes dwarfism The role of hypoxia-inducible factor-2 in digestive system cancers.FIP200, a key signaling node to coordinately regulate various cellular processes.Interdependence of cell attachment and cell cycle signaling.Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model Smooth muscle-like cells in pulmonary lymphangioleiomyomatosis.Inactivation of FIP200 leads to inflammatory skin disorder, but not tumorigenesis, in conditional knock-out mouse models.Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging.Genetics and molecular biology of tuberous sclerosis complex.Duplications in RB1CC1 are associated with schizophrenia; identification in large European sample sets.A comprehensive map of the mTOR signaling network.The ULK1 complex: sensing nutrient signals for autophagy activation.Autophagy in DNA damage response RB1CC1 protein positively regulates transforming growth factor-beta signaling through the modulation of Arkadia E3 ubiquitin ligase activity.Autophagy in cancer metastasis.The TSC1 and TSC2 tumor suppressors are required for proper ER stress response and protect cells from ER stress-induced apoptosis.Tyrosine phosphorylation of cofilin at Y68 by v-Src leads to its degradation through ubiquitin-proteasome pathway.Spatial interplay between PIASy and FIP200 in the regulation of signal transduction and transcriptional activity ULK1 inhibits mTORC1 signaling, promotes multisite Raptor phosphorylation and hinders substrate binding.The FoxO-BNIP3 axis exerts a unique regulation of mTORC1 and cell survival under energy stress.[Autophagy and vision].Functions of autophagy in the tumor microenvironment and cancer metastasis.FIP200 inhibits β-catenin-mediated transcription by promoting APC-independent β-catenin ubiquitination.BAP1 links metabolic regulation of ferroptosis to tumour suppression RB1CC1-enhanced autophagy facilitates PSCs activation and pancreatic fibrogenesis in chronic pancreatitis

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Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control

http://www.wikidata.org/entity/Q24679076

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2005 nî lūn-bûn

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2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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Identification of FIP200 inter ...... egulation of cell size control

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Identification of FIP200 inter ...... egulation of cell size control

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Identification of FIP200 inter ...... egulation of cell size control

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Boyi Gan

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Jun-Lin Guan

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Kun-Liang Guan

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Xiaoyang Wu

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Zara K Melkoumian

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P2860

Hamartin, the product of the tuberous sclerosis 1 (TSC1) gene, interacts with tuberin and appears to be localized to cytoplasmic vesicles

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

The TSC1 gene product, hamartin, negatively regulates cell proliferation

The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskeleton

Regulation of TSC2 by 14-3-3 binding

Interaction between hamartin and tuberin, the TSC1 and TSC2 gene products

Regulation of focal adhesion kinase by a novel protein inhibitor FIP200

The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells

Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling

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10.1083/JCB.200411106

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16043512

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2171462

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