Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function
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The NEDD8 modification pathway in plantsThe amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neuronsAn intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells.Analysis of the adenovirus E1B-55K-anchored proteome reveals its link to ubiquitination machinery.The CUL1 C-terminal sequence and ROC1 are required for efficient nuclear accumulation, NEDD8 modification, and ubiquitin ligase activity of CUL1Nedd8 modification of cul-1 activates SCF(beta(TrCP))-dependent ubiquitination of IkappaBalphaThe Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complexDysfunction of amyloid precursor protein signaling in neurons leads to DNA synthesis and apoptosisCullin family proteins and tumorigenesis: genetic association and molecular mechanismsCullin neddylation and substrate-adaptors counteract SCF inhibition by the CAND1-like protein Lag2 in Saccharomyces cerevisiae.The APC11 RING-H2 finger mediates E2-dependent ubiquitination.Covalent modification of all members of human cullin family proteins by NEDD8A dominant-negative UBC12 mutant sequesters NEDD8 and inhibits NEDD8 conjugation in vivoSubstrate-mediated regulation of cullin neddylationComponents of an SCF ubiquitin ligase localize to the centrosome and regulate the centrosome duplication cycleDegradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complexRegulation of the G1 to S transition by the ubiquitin pathway.AXR1-ECR1-dependent conjugation of RUB1 to the Arabidopsis Cullin AtCUL1 is required for auxin response.Phosphorylation of VACM-1/Cul5 by protein kinase A regulates its neddylation and antiproliferative effect.The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines.Role of chromosome 3p12-p21 tumour suppressor genes in clear cell renal cell carcinoma: analysis of VHL dependent and VHL independent pathways of tumorigenesis.COPing with hypoxiaThe NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and Therapy.Twists and turns in ubiquitin-like protein conjugation cascades.In vivo interference with Skp1 function leads to genetic instability and neoplastic transformationHypoxia-inducible factor α subunit stabilization by NEDD8 conjugation is reactive oxygen species-dependent.Phage display to identify Nedd8-mimicking peptides as inhibitors of the Nedd8 transfer cascade.Stabilization of HIF through inhibition of Cullin-2 neddylation is protective in mucosal inflammatory responsesProfiling the cross reactivity of ubiquitin with the Nedd8 activating enzyme by phage display.Regulation of neddylation and deneddylation of cullin1 in SCFSkp2 ubiquitin ligase by F-box protein and substrateThe RUB/Nedd8 conjugation pathway is required for early development in ArabidopsisPoxvirus Protein MC132 from Molluscum Contagiosum Virus Inhibits NF-B Activation by Targeting p65 for Degradation.A Nedd8 conjugation pathway is essential for proteolytic targeting of p27Kip1 by ubiquitination.Ubiquitin-like protein activation.Human placental hypoxia-inducible factor-1alpha expression correlates with clinical outcomes in chronic hypoxia in vivo.Central role for endothelial human deneddylase-1/SENP8 in fine-tuning the vascular inflammatory response.The Arabidopsis cullin AtCUL1 is modified by the ubiquitin-related protein RUB1.The cyclomodulin cycle inhibiting factor (CIF) alters cullin neddylation dynamics.Elongin BC complex prevents degradation of von Hippel-Lindau tumor suppressor gene products.
P2860
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P2860
Conjugation of the ubiquitin-like protein NEDD8 to cullin-2 is linked to von Hippel-Lindau tumor suppressor function
description
1999 nî lūn-bûn
@nan
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Conjugation of the ubiquitin-l ...... ndau tumor suppressor function
@ast
Conjugation of the ubiquitin-l ...... ndau tumor suppressor function
@en
Conjugation of the ubiquitin-l ...... ndau tumor suppressor function
@nl
type
label
Conjugation of the ubiquitin-l ...... ndau tumor suppressor function
@ast
Conjugation of the ubiquitin-l ...... ndau tumor suppressor function
@en
Conjugation of the ubiquitin-l ...... ndau tumor suppressor function
@nl
prefLabel
Conjugation of the ubiquitin-l ...... ndau tumor suppressor function
@ast
Conjugation of the ubiquitin-l ...... ndau tumor suppressor function
@en
Conjugation of the ubiquitin-l ...... ndau tumor suppressor function
@nl
P2093
P2860
P356
P1476
Conjugation of the ubiquitin-l ...... ndau tumor suppressor function
@en
P2093
P2860
P304
P356
10.1073/PNAS.96.10.5510
P407
P577
1999-05-11T00:00:00Z