The major human and mouse granzymes are structurally and functionally divergent - Wikidata - thesis-toulmin - TriplyDB

The major human and mouse granzymes are structurally and functionally divergent

The major human and mouse granzymes are structurally and functionally divergent

http://www.wikidata.org/entity/Q24682724

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Cathepsin H is an additional convertase of pro-granzyme B Granzyme B degrades extracellular matrix and contributes to delayed wound closure in apolipoprotein E knockout mice Granzyme B cleavage of autoantigens in autoimmunity Perforin-independent extracellular granzyme B activity contributes to abdominal aortic aneurysm Low concentrations of the soy phytoestrogen genistein induce proteinase inhibitor 9 and block killing of breast cancer cells by immune cells Granzyme H destroys the function of critical adenoviral proteins required for viral DNA replication and granzyme B inhibition Structure of granzyme C reveals an unusual mechanism of protease autoinhibition SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G A natural genetic variant of granzyme B confers lethality to a common viral infection Immunotherapeutic targeting of membrane Hsp70-expressing tumors using recombinant human granzyme B Granzyme B cleaves decorin, biglycan and soluble betaglycan, releasing active transforming growth factor-β1 The effector T cell response to influenza infection Granzyme B triggers a prolonged pressure to die in Bcl-2 overexpressing cells, defining a window of opportunity for effective treatment with ABT-737 Mouse granzyme A induces a novel death with writhing morphology that is mechanistically distinct from granzyme B-induced apoptosis Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidases Granzyme A- and B-cluster deficiency delays acute lung injury in pneumovirus-infected mice The granzyme B-Serpinb9 axis controls the fate of lymphocytes after lysosomal stress.Proteomic profiling of proteases: tools for granzyme degradomics.Human and mouse granzyme M display divergent and species-specific substrate specificities.In vivo elimination of MHC-I-deficient lymphocytes by activated natural killer cells is independent of granzymes A and B.Cleavage of von Willebrand factor by granzyme M destroys its factor VIII binding capacity.Delivery and therapeutic potential of human granzyme B.Serpinb9 (Spi6)-deficient mice are impaired in dendritic cell-mediated antigen cross-presentation.Protein multifunctionality: principles and mechanisms.Perforin: structure, function, and role in human immunopathology.Molecular determinants of the substrate specificity of the complement-initiating protease, C1r.MAIT cells are licensed through granzyme exchange to kill bacterially sensitized targets.A colorimetric assay that specifically measures Granzyme B proteolytic activity: hydrolysis of Boc-Ala-Ala-Asp-S-Bzl Importance of extended protease substrate recognition motifs in steering BNIP-2 cleavage by human and mouse granzymes B.Granzyme B-induced mitochondrial ROS are required for apoptosis Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution.Granzyme B-inhibitor serpina3n induces neuroprotection in vitro and in vivo.Human and murine granzyme B exhibit divergent substrate preferences Localization of CD8 T cell epitope within cardiac myosin heavy chain-α334-352 that induces autoimmune myocarditis in A/J mice A Novel Serpin Regulatory Mechanism: SerpinB9 IS REVERSIBLY INHIBITED BY VICINAL DISULFIDE BOND FORMATION IN THE REACTIVE CENTER LOOP Expression of high levels of human proteinase inhibitor 9 blocks both perforin/granzyme and Fas/Fas ligand-mediated cytotoxicity.Mechanisms of granule-dependent killing.Non-apoptotic functions of granzymes.The role of serpins in vertebrate immunity.Conservation of the extended substrate specificity profiles among homologous granzymes across species.

P2860

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P2860

The major human and mouse granzymes are structurally and functionally divergent

http://www.wikidata.org/entity/Q24682724

description

2006 nî lūn-bûn

@nan

2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2006 թվականի նոյեմբերին հրատարակված գիտական հոդված

@hy

2006年の論文

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2006年論文

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2006年論文

@zh-hant

2006年論文

@zh-hk

2006年論文

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2006年論文

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2006年论文

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name

The major human and mouse granzymes are structurally and functionally divergent

@ast

The major human and mouse granzymes are structurally and functionally divergent

@en

The major human and mouse granzymes are structurally and functionally divergent

@nl

type

label

The major human and mouse granzymes are structurally and functionally divergent

@ast

The major human and mouse granzymes are structurally and functionally divergent

@en

The major human and mouse granzymes are structurally and functionally divergent

@nl

prefLabel

The major human and mouse granzymes are structurally and functionally divergent

@ast

The major human and mouse granzymes are structurally and functionally divergent

@en

The major human and mouse granzymes are structurally and functionally divergent

@nl

P1433

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P3181

P356

P1433

Journal of Cell Biology

P1476

The major human and mouse granzymes are structurally and functionally divergent

@en

P2093

Antony Matthews

http://www.w3.org/2001/XMLSchema#string

Catherina H Bird

http://www.w3.org/2001/XMLSchema#string

Dion Kaiserman

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Jiuru Sun

http://www.w3.org/2001/XMLSchema#string

Kheng Ung

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P2860

A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes

The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1

The oligomeric structure of human granzyme A is a determinant of its extended substrate specificity

On the size of the active site in proteases. I. Papain

The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency

Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction

Serpin structure, mechanism, and function

Neutrophil elastase targets virulence factors of enterobacteria

Human and murine cytotoxic T lymphocyte serine proteases: subsite mapping with peptide thioester substrates and inhibition of enzyme activity and cytolysis by isocoumarins

Production and characterization of recombinant human proteinase inhibitor 6 expressed in Pichia pastoris

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619-30

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scholarly article

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1817956

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10.1083/JCB.200606073

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P407

P433

4

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P478

175

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P50

James C Whisstock

Philip E. Thompson

Joseph A Trapani

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2006-11-20T00:00:00Z

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6680733

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17116752

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2064598

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