Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice
about
Physical and functional interaction of the Werner syndrome protein with poly-ADP ribosyl transferaseIdentification and biochemical characterization of a Werner's syndrome protein complex with Ku70/80 and poly(ADP-ribose) polymerase-1Human premature aging, DNA repair and RecQ helicasesPleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammationMetabolic and Phenotypic Differences between Mice Producing a Werner Syndrome Helicase Mutant Protein and Wrn Null MiceWerner syndrome: Clinical features, pathogenesis and potential therapeutic interventionsPARP-1 expression and activity in primary human lung cells.Expression profiling of mouse embryonic fibroblasts with a deletion in the helicase domain of the Werner Syndrome gene homologue treated with hydrogen peroxide.Liver aging and pseudocapillarization in a Werner syndrome mouse model.Expression profile of Caenorhabditis elegans mutant for the Werner syndrome gene ortholog reveals the impact of vitamin C on development to increase life span.The Werner syndrome helicase protein is required for cell proliferation, immortalization, and tumorigenesis in Scaffold attachment factor B1 deficient mice.Vitamin C restores healthy aging in a mouse model for Werner syndromeClassifying DNA repair genes by kernel-based support vector machines.Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities.DNA helicases involved in DNA repair and their roles in cancerProteome-wide identification of WRN-interacting proteins in untreated and nuclease-treated samples.Poly(ADP-ribosyl)ation in mammalian ageing.Down regulation of miR-124 in both Werner syndrome DNA helicase mutant mice and mutant Caenorhabditis elegans wrn-1 reveals the importance of this microRNA in accelerated agingSite-specific noncovalent interaction of the biopolymer poly(ADP-ribose) with the Werner syndrome protein regulates protein functions.DNA repair and PARP in aging.Identification and characterization of a Drosophila ortholog of WRN exonuclease that is required to maintain genome integrity.Vitamin C modulates the metabolic and cytokine profiles, alleviates hepatic endoplasmic reticulum stress, and increases the life span of Gulo-/- mice.PolyADP-ribosylation and cancer.From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing.Rapid regulation of telomere length is mediated by poly(ADP-ribose) polymerase-1.Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage.Poly(ADP-ribose) polymerase 1 regulates both the exonuclease and helicase activities of the Werner syndrome protein.Different non-synonymous polymorphisms modulate the interaction of the WRN protein to its protein partners and its enzymatic activities.Ascorbate improves metabolic abnormalities in Wrn mutant mice but not the free radical scavenger catechin.PARP-1 and PARP-2: New players in tumour development.Mass spectrometry-based functional proteomics of poly(ADP-ribose) polymerase-1.Coordination of DNA single strand break repair.Werner syndrome protein prevents DNA breaks upon chromatin structure alteration.Poly(ADP-ribose) polymerase (PARP-1) and p53 independently function in regulating double-strand break repair in primate cells.Divergent cellular phenotypes of human and mouse cells lacking the Werner syndrome RecQ helicase.Recent Advances in Understanding Werner Syndrome.Resveratrol improves insulin resistance hyperglycemia and hepatosteatosis but not hypertriglyceridemia, inflammation, and life span in a mouse model for Werner syndrome.Serum vitamin C levels modulate the lifespan and endoplasmic reticulum stress response pathways in mice synthesizing a nonfunctional mutant WRN protein.Poly(ADP-ribose) polymerase-1 plays a role in suppressing mammary tumourigenesis in mice.Role of oxidative and nitrosative stress, longevity genes and poly(ADP-ribose) polymerase in cardiovascular dysfunction associated with aging.
P2860
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P2860
Genetic cooperation between the Werner syndrome protein and poly(ADP-ribose) polymerase-1 in preventing chromatid breaks, complex chromosomal rearrangements, and cancer in mice
description
2003 nî lūn-bûn
@nan
2003 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Genetic cooperation between th ...... rangements, and cancer in mice
@ast
Genetic cooperation between th ...... rangements, and cancer in mice
@en
Genetic cooperation between th ...... rangements, and cancer in mice
@nl
type
label
Genetic cooperation between th ...... rangements, and cancer in mice
@ast
Genetic cooperation between th ...... rangements, and cancer in mice
@en
Genetic cooperation between th ...... rangements, and cancer in mice
@nl
prefLabel
Genetic cooperation between th ...... rangements, and cancer in mice
@ast
Genetic cooperation between th ...... rangements, and cancer in mice
@en
Genetic cooperation between th ...... rangements, and cancer in mice
@nl
P2093
P2860
P1476
Genetic cooperation between th ...... rangements, and cancer in mice
@en
P2093
Isabelle Gaudreault
Josée Lavoie
Marc Bronsard
Michel Lebel
Régen Drouin
P2860
P304
P356
10.1016/S0002-9440(10)64290-3
P407
P577
2003-05-01T00:00:00Z