APE1 overexpression in XRCC1-deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instability
about
XRCC1 is required for DNA single-strand break repair in human cells.Human AP endonuclease suppresses DNA mismatch repair activity leading to microsatellite instability.p53 coordinates base excision repair to prevent genomic instabilityThe many functions of APE1/Ref-1: not only a DNA repair enzymeXPD DNA nucleotide excision repair gene polymorphisms associated with DNA repair deficiency predict better treatment outcomes in secondary acute myeloid leukemia.Interaction with OGG1 is required for efficient recruitment of XRCC1 to base excision repair and maintenance of genetic stability after exposure to oxidative stressUbiquitin ligase UBR3 regulates cellular levels of the essential DNA repair protein APE1 and is required for genome stabilityXRCC1 and DNA polymerase beta in cellular protection against cytotoxic DNA single-strand breaks.Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions.DNA 3'-phosphatase activity is critical for rapid global rates of single-strand break repair following oxidative stress.Deregulation of base excision repair gene expression and enhanced proliferation in head and neck squamous cell carcinoma.Triptolide induces DNA breaks, activates caspase-3-dependent apoptosis and sensitizes B-cell lymphoma to poly(ADP-ribose) polymerase 1 and phosphoinositide 3-kinase inhibitors.Association of DNA repair genes polymorphisms and mutations with increased risk of head and neck cancer: a review.The DNA damage response (DDR) is induced by the C9orf72 repeat expansion in amyotrophic lateral sclerosis.Programming of Cell Resistance to Genotoxic and Oxidative Stress.
P2860
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P2860
APE1 overexpression in XRCC1-deficient cells complements the defective repair of oxidative single strand breaks but increases genomic instability
description
2005 nî lūn-bûn
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2005 թուականին հրատարակուած գիտական յօդուած
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2005 թվականին հրատարակված գիտական հոդված
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2005年の論文
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2005年論文
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2005年論文
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2005年論文
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2005年論文
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2005年論文
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2005年论文
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name
APE1 overexpression in XRCC1-d ...... increases genomic instability
@ast
APE1 overexpression in XRCC1-d ...... increases genomic instability
@en
APE1 overexpression in XRCC1-d ...... increases genomic instability
@nl
type
label
APE1 overexpression in XRCC1-d ...... increases genomic instability
@ast
APE1 overexpression in XRCC1-d ...... increases genomic instability
@en
APE1 overexpression in XRCC1-d ...... increases genomic instability
@nl
prefLabel
APE1 overexpression in XRCC1-d ...... increases genomic instability
@ast
APE1 overexpression in XRCC1-d ...... increases genomic instability
@en
APE1 overexpression in XRCC1-d ...... increases genomic instability
@nl
P2093
P2860
P356
P1476
APE1 overexpression in XRCC1-d ...... increases genomic instability
@en
P2093
Claudia Flohr-Beckhaus
Ina Schulz
J Pablo Radicella
Marguerite Sossou
P2860
P304
P356
10.1093/NAR/GKI173
P407
P577
2005-01-01T00:00:00Z