Mre11 assembles linear DNA fragments into DNA damage signaling complexes
about
ATM-dependent phosphorylation of ATF2 is required for the DNA damage responseDisruption of mechanisms that prevent rereplication triggers a DNA damage responseDNA damage induces nucleoid compaction via the Mre11-Rad50 complex in the archaeon Haloferax volcaniiMre11-Rad50-Nbs1-dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activityThe Fanconi anemia protein FANCM is controlled by FANCD2 and the ATR/ATM pathwaysStructure of Mre11–Nbs1 complex yields insights into ataxia-telangiectasia–like disease mutations and DNA damage signalingSen1p contributes to genomic integrity by regulating expression of ribonucleotide reductase 1 (RNR1) in Saccharomyces cerevisiae.Rad50 adenylate kinase activity regulates DNA tethering by Mre11/Rad50 complexes.Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damageThe MRN-CtIP pathway is required for metaphase chromosome alignment.A distinct H2A.X isoform is enriched in Xenopus laevis eggs and early embryos and is phosphorylated in the absence of a checkpoint.Distinct modes of ATR activation after replication stress and DNA double-strand breaks in Caenorhabditis elegans.ATR and ATM regulate the timing of DNA replication origin firing.Independent and sequential recruitment of NHEJ and HR factors to DNA damage sites in mammalian cells.An ATM- and ATR-dependent checkpoint inactivates spindle assembly by targeting CEP63.ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1.The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor.Distribution and dynamics of chromatin modification induced by a defined DNA double-strand breakNBS1 cooperates with homologous recombination to counteract chromosome breakage during replication.Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models.ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaksMCL-1 localizes to sites of DNA damage and regulates DNA damage responseMutations in Mre11 phosphoesterase motif I that impair Saccharomyces cerevisiae Mre11-Rad50-Xrs2 complex stability in addition to nuclease activityATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks.A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complexPloidy dictates repair pathway choice under DNA replication stress.Involvement of novel autophosphorylation sites in ATM activationThe Rad50 coiled-coil domain is indispensable for Mre11 complex functionsChecking on DNA damage in S phase.Centromeric DNA replication reconstitution reveals DNA loops and ATR checkpoint suppressionDistinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosisRad50 zinc hook is important for the Mre11 complex to bind chromosomal DNA double-stranded breaks and initiate various DNA damage responses.Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11.The emerging role of nuclear architecture in DNA repair and genome maintenance.MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA.Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex.The Mre11-Rad50-Nbs1 complex mediates activation of TopBP1 by ATMDeficiency of the DNA repair enzyme ATM in rheumatoid arthritis.Choreography of recombination proteins during the DNA damage response.
P2860
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P2860
Mre11 assembles linear DNA fragments into DNA damage signaling complexes
description
2004 nî lūn-bûn
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2004 թուականի Մայիսին հրատարակուած գիտական յօդուած
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2004 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2004年の論文
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2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
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2004年论文
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name
Mre11 assembles linear DNA fragments into DNA damage signaling complexes
@ast
Mre11 assembles linear DNA fragments into DNA damage signaling complexes
@en
Mre11 assembles linear DNA fragments into DNA damage signaling complexes
@nl
type
label
Mre11 assembles linear DNA fragments into DNA damage signaling complexes
@ast
Mre11 assembles linear DNA fragments into DNA damage signaling complexes
@en
Mre11 assembles linear DNA fragments into DNA damage signaling complexes
@nl
prefLabel
Mre11 assembles linear DNA fragments into DNA damage signaling complexes
@ast
Mre11 assembles linear DNA fragments into DNA damage signaling complexes
@en
Mre11 assembles linear DNA fragments into DNA damage signaling complexes
@nl
P2093
P2860
P3181
P1433
P1476
Mre11 assembles linear DNA fragments into DNA damage signaling complexes
@en
P2093
Jean Gautier
Max Gottesman
Tanya Paull
P2860
P3181
P356
10.1371/JOURNAL.PBIO.0020110
P407
P577
2004-05-01T00:00:00Z