Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure
about
A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidizationCentrosomes, chromosome instability (CIN) and aneuploidyDNA damage associated with mitosis and cytokinesis failureCell-based screen for altered nuclear phenotypes reveals senescence progression in polyploid cells after Aurora kinase B inhibition.Plk1 inhibition causes post-mitotic DNA damage and senescence in a range of human tumor cell linesTranscriptome analysis of tetraploid cells identifies cyclin D2 as a facilitator of adaptation to genome doubling in the presence of p53p53 suppresses tetraploid development in miceCytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cellsHuman cancer cells commonly acquire DNA damage during mitotic arrest.Nucleoside diphosphate kinase Nm23-H1 regulates chromosomal stability by activating the GTPase dynamin during cytokinesis.A non-genetic route to aneuploidy in human cancersInterphase cytofission maintains genomic integrity of human cells after failed cytokinesis.Failure of cell cleavage induces senescence in tetraploid primary cells.High-throughput screens in diploid cells identify factors that contribute to the acquisition of chromosomal instabilityp53 suppresses structural chromosome instability after mitotic arrest in human cells.p53 dependent centrosome clustering prevents multipolar mitosis in tetraploid cellsEssential dosage-dependent functions of the transcription factor yin yang 1 in late embryonic development and cell cycle progression.3-D DNA methylation phenotypes correlate with cytotoxicity levels in prostate and liver cancer cell models.Elucidation of proliferative capability of mononuclear tetraploid cells, emerging spontaneously from diploid cells, using image cytometry and fluorescence in situ hybridization.Genomic Instability Induced By Human Papillomavirus Oncogenes.Role of Cdk1 in the p53-independent abrogation of the postmitotic checkpoint by human papillomavirus E6Overexpression of N-terminal kinase like gene promotes tumorigenicity of hepatocellular carcinoma by regulating cell cycle progression and cell motility.p53: guardian of ploidyThe expanding implications of polyploidy.Chromosome mis-segregation and cytokinesis failure in trisomic human cellsSurveillance mechanism linking Bub1 loss to the p53 pathway.Losing balance: the origin and impact of aneuploidy in cancerCell cycle control in acute myeloid leukemia.Doubling the deck: Tetraploidy induces chromosome shuffling and cancerIdentification of Selective Lead Compounds for Treatment of High-Ploidy Breast CancerA mechanosensory system controls cell shape changes during mitosis.Tetraploid cells produced by absence of substrate adhesion during cytokinesis are limited in their proliferation and enter senescence after DNA replicationIndicators of replicative damage in equine tendon fibroblast monolayersEffects of whole genome duplication on cell size and gene expression in mouse embryonic stem cells.Role of prolonged mitotic checkpoint activation in the formation and treatment of cancer.Cytokinesis and cancer.Targeting aneuploid cancer cells.Mitosis as an anti-cancer target.Mitosis as an anti-cancer drug target.Molecular mechanisms controlling the cell cycle in embryonic stem cells.
P2860
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P2860
Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure
description
2005 nî lūn-bûn
@nan
2005 թուականին հրատարակուած գիտական յօդուած
@hyw
2005 թվականին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
Mammalian cells lack checkpoin ...... umber, and cytokinesis failure
@ast
Mammalian cells lack checkpoin ...... umber, and cytokinesis failure
@en
Mammalian cells lack checkpoin ...... umber, and cytokinesis failure
@nl
type
label
Mammalian cells lack checkpoin ...... umber, and cytokinesis failure
@ast
Mammalian cells lack checkpoin ...... umber, and cytokinesis failure
@en
Mammalian cells lack checkpoin ...... umber, and cytokinesis failure
@nl
prefLabel
Mammalian cells lack checkpoin ...... umber, and cytokinesis failure
@ast
Mammalian cells lack checkpoin ...... umber, and cytokinesis failure
@en
Mammalian cells lack checkpoin ...... umber, and cytokinesis failure
@nl
P2860
P3181
P356
P1433
P1476
Mammalian cells lack checkpoin ...... umber, and cytokinesis failure
@en
P2093
Connie Wong
P2860
P2888
P3181
P356
10.1186/1471-2121-6-6
P407
P50
P577
2005-02-15T00:00:00Z
P5875
P6179
1051963531