(-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance.
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BH3 mimetics to improve cancer therapy; mechanisms and examplesStable low-level expression of p21WAF1/CIP1 in A549 human bronchogenic carcinoma cell line-derived clones down-regulates E2F1 mRNA and restores cell proliferation controlBcl-2 antagonists: a proof of concept for CLL therapyCombination therapy with gossypol reveals synergism against gemcitabine resistance in cancer cells with high BCL-2 expressionTargeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancerTranscriptional responses underlying the hormetic and detrimental effects of the plant secondary metabolite gossypol on the generalist herbivore Helicoverpa armigeraPhosphoproteomic analysis of gossypol-induced apoptosis in ovarian cancer cell line, HOC1a.Proteomic analysis of gossypol induces necrosis in multiple myeloma cells.Gossypol induces death receptor-5 through activation of the ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAILTubulin-targeting chemotherapy impairs androgen receptor activity in prostate cancer.Radiosensitization in prostate cancer: mechanisms and targetsAmphipathic tail-anchoring peptide and Bcl-2 homology domain-3 (BH3) peptides from Bcl-2 family proteins induce apoptosis through different mechanismsBNIP3 regulates AT101 [(-)-gossypol] induced death in malignant peripheral nerve sheath tumor cells.High Throughput Screen Identifies Natural Product Inhibitor of Phenylalanyl-tRNA Synthetase from Pseudomonas aeruginosa and Streptococcus pneumoniae.Proapoptotic protein Smac mediates apoptosis in cisplatin-resistant ovarian cancer cells when treated with the anti-tumor agent AT101.Small-molecule BH3 mimetic and pan-Bcl-2 inhibitor AT-101 enhances the antitumor efficacy of cisplatin through inhibition of APE1 repair and redox activity in non-small-cell lung cancer.Evaluation of anticancer properties of a decoction containing Adenanthera pavonina L. and Thespesia populnea LIonizing radiation induces myofibroblast differentiation via lactate dehydrogenaseInvestigations on gossypol: past and present developments.A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed.Inhibitors of the anti-apoptotic Bcl-2 proteins: a patent review.WL-276, an antagonist against Bcl-2 proteins, overcomes drug resistance and suppresses prostate tumor growth.Chelerythrine induces apoptosis through a Bax/Bak-independent mitochondrial mechanism.Gossypol-Induced Differentiation in Human Leukemia HL-60 Cells.Gossypol, a BH3 mimetic, induces apoptosis in chronic lymphocytic leukemia cellsMetronomic dosing of BH3 mimetic small molecule yields robust antiangiogenic and antitumor effectsExpanding circle of inhibition: small-molecule inhibitors of Bcl-2 as anticancer cell and antiangiogenic agents.Characterization and modeling of the oligomeric state and ligand binding behavior of purified translocator protein 18 kDa from Rhodobacter sphaeroides.Haplotype and diplotype analyses of variation in ERCC5 transcription cis-regulation in normal bronchial epithelial cellsGossypol acetic acid induces apoptosis in RAW264.7 cells via a caspase-dependent mitochondrial signaling pathwayHydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker.AT-101, a small molecule inhibitor of anti-apoptotic Bcl-2 family members, activates the SAPK/JNK pathway and enhances radiation-induced apoptosis.R-(-)-gossypol (AT-101) activates programmed cell death in multiple myeloma cells.How to unleash mitochondrial apoptotic blockades to kill cancers?Small mitochondria-targeting molecules as anti-cancer agents.Involvement of Bcl-2, Src, and ERα in gossypol-mediated growth inhibition and apoptosis in human uterine leiomyoma and myometrial cells.Dietary gossypol suppressed postprandial TOR signaling and elevated ER stress pathways in turbot (Scophthalmus maximus L.).Acetogenins from Annona muricata as potential inhibitors of antiapoptotic proteins: a molecular modeling studyA novel BH3 mimetic efficiently induces apoptosis in melanoma cells through direct binding to anti-apoptotic Bcl-2 family proteins, including phosphorylated Mcl-1.Musashi RNA-Binding Proteins as Cancer Drivers and Novel Therapeutic Targets.
P2860
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P2860
(-)-Gossypol acts directly on the mitochondria to overcome Bcl-2- and Bcl-X(L)-mediated apoptosis resistance.
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
(-)-Gossypol acts directly on ...... mediated apoptosis resistance.
@ast
(-)-Gossypol acts directly on ...... mediated apoptosis resistance.
@en
Variation in transcriptional r ...... human bronchogenic carcinomas
@nl
type
label
(-)-Gossypol acts directly on ...... mediated apoptosis resistance.
@ast
(-)-Gossypol acts directly on ...... mediated apoptosis resistance.
@en
Variation in transcriptional r ...... human bronchogenic carcinomas
@nl
prefLabel
(-)-Gossypol acts directly on ...... mediated apoptosis resistance.
@ast
(-)-Gossypol acts directly on ...... mediated apoptosis resistance.
@en
Variation in transcriptional r ...... human bronchogenic carcinomas
@nl
P2093
P2860
P3181
P356
P1476
(-)-Gossypol acts directly on ...... mediated apoptosis resistance.
@en
P2093
Christopher L Oliver
Daniel E Johnson
Michelle B Miranda
Sanjeev Shangary
Shaomeng Wang
Stephanie Land
P2860
P3181
P356
10.1186/1476-4598-4-23
P407
P577
2005-01-01T00:00:00Z