A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response - Wikidata - thesis-toulmin - TriplyDB

A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response

A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response

http://www.wikidata.org/entity/Q26774980

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MUC1-C activates BMI1 in human cancer cells.miR-15a/miR-16 down-regulates BMI1, impacting Ub-H2A mediated DNA repair and breast cancer cell sensitivity to doxorubicin BMI1 reduces ATR activation and signalling caused by hydroxyurea.miR-218 inhibits acute promyelocytic leukemia cell growth by targeting BMI-1.MUC1-C activates polycomb repressive complexes and downregulates tumor suppressor genes in human cancer cells.The poor outcome of second primary oral squamous cell carcinoma is attributed to Bmi1 upregulation.Etoposide-induced DNA damage affects multiple cellular pathways in addition to DNA damage response.

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A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response

http://www.wikidata.org/entity/Q26774980

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2015 nî lūn-bûn

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2015 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2015年の論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年論文

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2015年论文

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name

A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response

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A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response

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A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response

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A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response

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A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response

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A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response

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A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response

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A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response

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A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response

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A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response

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Damu Tang

http://www.w3.org/2001/XMLSchema#string

Diane Ojo

http://www.w3.org/2001/XMLSchema#string

Fengxiang Wei

http://www.w3.org/2001/XMLSchema#string

Nicholas Wong

http://www.w3.org/2001/XMLSchema#string

Xiaozeng Lin

http://www.w3.org/2001/XMLSchema#string

Yan Gu

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Creative Commons Attribution

P2860

Ubiquitination regulates PTEN nuclear import and tumor suppression

MDC1 is a mediator of the mammalian DNA damage checkpoint

RNF168 ubiquitinates K13-15 on H2A/H2AX to drive DNA damage signaling

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins

RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly

A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin

Role of histone H2A ubiquitination in Polycomb silencing

The RIDDLE syndrome protein mediates a ubiquitin-dependent signaling cascade at sites of DNA damage

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3396-415

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10.3390/BIOM5043396

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