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Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum DisordersEmerging roles for histone deacetylases in pulmonary hypertension and right ventricular remodeling (2013 Grover Conference series)Acetyl-lysine erasers and readers in the control of pulmonary hypertension and right ventricular hypertrophyHDAC8 overexpression in mesenchymal stromal cells from JAK2+ myeloproliferative neoplasms: a new therapeutic target?Thermodynamics of binding of structurally similar ligands to histone deacetylase 8 sheds light on challenges in the rational design of potent and isozyme-selective inhibitors of the enzymeMechanism of N-Acylthiourea-mediated activation of human histone deacetylase 8 (HDAC8) at molecular and cellular levels.Variable active site loop conformations accommodate the binding of macrocyclic largazole analogues to HDAC8Non-sirtuin histone deacetylases in the control of cardiac agingHDAC8, A Potential Therapeutic Target for the Treatment of Malignant Peripheral Nerve Sheath Tumors (MPNST)KDAC8 with High Basal Velocity Is Not Activated by N-Acetylthioureas.Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase.Biochemical and structural characterization of HDAC8 mutants associated with Cornelia de Lange syndrome spectrum disordersNon-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability.Inhibition of Interleukin 1β (IL-1β) Expression by Anthrax Lethal Toxin (LeTx) Is Reversed by Histone Deacetylase 8 (HDAC8) Inhibition in Murine Macrophages.Transcription and beyond: the role of mammalian class I lysine deacetylasesLysine Deacetylases Exhibit Distinct Changes in Activity Profiles Due to Fluorophore Conjugation of Substrates.Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases.HDAC8-mediated epigenetic reprogramming plays a key role in resistance to anthrax lethal toxin-induced pyroptosis in macrophages.KDAC8 substrate specificity quantified by a biologically relevant, label-free deacetylation assay.Real-time monitoring of conformational transitions of single-molecule histone deacetylase 8 with nanocircuits.Restoring histone deacetylase activity by waste product release. A view from molecular mechanics simulations with mammalian HDAC8.Structure-Based Identification of HDAC8 Non-histone SubstratesKinetics and thermodynamics of metal-binding to histone deacetylase 8.Development of a Potent and Selective HDAC8 Inhibitor.An unbiased approach to identify endogenous substrates of "histone" deacetylase 8.Structural and Functional Influence of the Glycine-Rich Loop G302GGGY on the Catalytic Tyrosine of Histone Deacetylase 8.HDAC8 substrate selectivity is determined by long- and short-range interactions leading to enhanced reactivity for full-length histone substrates compared with peptides.Active Site Metal Identity Alters Histone Deacetylase 8 Substrate Selectivity: A Potential Novel Regulatory Mechanism.Novel histone deacetylase 8-selective inhibitor 1,3,4-oxadiazole-alanine hybrid induces apoptosis in breast cancer cells.HDAC8 Substrates Identified by Genetically Encoded Active Site Photocrosslinking.Overexpressed HDAC8 in cervical cancer cells shows functional redundancy of tubulin deacetylation with HDAC6.β-adrenergic Receptor Stimulation Revealed a Novel Regulatory Pathway via Suppressing Histone Deacetylase 3 to Induce Uncoupling Protein 1 Expression in Mice Beige Adipocyte
P2860
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P2860
description
2013 nî lūn-bûn
@nan
2013 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
HDAC8 substrates: Histones and beyond
@ast
HDAC8 substrates: Histones and beyond
@en
HDAC8 substrates: Histones and beyond
@nl
type
label
HDAC8 substrates: Histones and beyond
@ast
HDAC8 substrates: Histones and beyond
@en
HDAC8 substrates: Histones and beyond
@nl
prefLabel
HDAC8 substrates: Histones and beyond
@ast
HDAC8 substrates: Histones and beyond
@en
HDAC8 substrates: Histones and beyond
@nl
P2093
P2860
P356
P1433
P1476
HDAC8 substrates: Histones and beyond
@en
P2093
Carol A. Fierke
Carol Ann Pitcairn
Noah A. Wolfson
P2860
P304
P356
10.1002/BIP.22135
P407
P577
2013-02-01T00:00:00Z