The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality - Wikidata - thesis-toulmin - TriplyDB

The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality

The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality

http://www.wikidata.org/entity/Q26998816

about

The next generation of risk assessment multiyear study - highlights of findings, applications to risk assessment, and future directions Environmental Chemical Assessment in Clinical Practice: Unveiling the Elephant in the Room Big data in chemical toxicity research: the use of high-throughput screening assays to identify potential toxicants Mechanism Profiling of Hepatotoxicity Caused by Oxidative Stress Using Antioxidant Response Element Reporter Gene Assay Models and Big Data Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: focus on the cancer hallmark of tumor angiogenesis Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms The eTOX data-sharing project to advance in silico drug-induced toxicity prediction Quantitative high-throughput screening data analysis: challenges and recent advances CEBS: a comprehensive annotated database of toxicological data Identifying Chemical Groups for Biomonitoring Editor's Highlight: Development of an In vitro Assay Measuring Uterine-Specific Estrogenic Responses for Use in Chemical Safety Assessment CERAPP: Collaborative Estrogen Receptor Activity Prediction Project Intersection of toxicogenomics and high throughput screening in the Tox21 program: an NIEHS perspective Global analysis of publicly available safety data for 9,801 substances registered under REACH from 2008-2014 Elucidating mechanisms of toxicity using phenotypic data from primary human cell systems--a chemical biology approach for thrombosis-related side effects.Using ToxCast™ Data to Reconstruct Dynamic Cell State Trajectories and Estimate Toxicological Points of Departure.A Quantitative High-Throughput Screening Data Analysis Pipeline for Activity Profiling.Correction of Microplate Data from High-Throughput Screening.Rethinking Environmental Protection: Meeting the Challenges of a Changing World.Profiling of the Tox21 10K compound library for agonists and antagonists of the estrogen receptor alpha signaling pathway Profiling of the Tox21 chemical collection for mitochondrial function to identify compounds that acutely decrease mitochondrial membrane potential.International STakeholder NETwork (ISTNET): creating a developmental neurotoxicity (DNT) testing road map for regulatory purposes Predicting the future: opportunities and challenges for the chemical industry to apply 21st-century toxicity testing.Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform.Identification of compounds that modulate retinol signaling using a cell-based qHTS assay.Incorporating High-Throughput Exposure Predictions With Dosimetry-Adjusted In Vitro Bioactivity to Inform Chemical Toxicity Testing.Identifying environmental chemicals as agonists of the androgen receptor by using a quantitative high-throughput screening platform.Incorporation of metabolic activation potentiates cyclophosphamide-induced DNA damage response in isogenic DT40 mutant cells Modelling the Tox21 10 K chemical profiles for in vivo toxicity prediction and mechanism characterization.A Quantitative Approach to Screen for Nephrotoxic Compounds In Vitro Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor Arbitrarily Accessible 3D Microfluidic Device for Combinatorial High-Throughput Drug Screening.Advancing toxicology research using in vivo high throughput toxicology with small fish models.Poor recognition of O6-isopropyl dG by MGMT triggers double strand break-mediated cell death and micronucleus induction in FANC-deficient cells.Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups.An "EAR" on Environmental Surveillance and Monitoring: A Case Study on the Use of Exposure-Activity Ratios (EARs) to Prioritize Sites, Chemicals, and Bioactivities of Concern in Great Lakes Waters.Identification of acetylcholinesterase inhibitors using homogenous cell-based assays in quantitative high-throughput screening platforms.In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities.High-Performance Prediction of Human Estrogen Receptor Agonists Based on Chemical Structures.Alternative approaches for identifying acute systemic toxicity: Moving from research to regulatory testing.

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The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality

http://www.wikidata.org/entity/Q26998816

description

2013 nî lūn-bûn

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2013 թուականի Մայիսին հրատարակուած գիտական յօդուած

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J.DRUDIS.2013.05.015

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Drug Discovery Today

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Matias S Attene-Ramos

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Menghang Xia

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Misha Itkin

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Nicole Miller

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Paul Shinn

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Raymond R Tice

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Robert J Kavlock

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Ruili Huang

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Sam Michael

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Compound Management for Quantitative High-Throughput Screening

Toxicity testing in the 21st century: a vision and a strategy

A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays

Perspectives on validation of high-throughput assays supporting 21st century toxicity testing

Paradigm shift in toxicity testing and modeling.

Predictive model of rat reproductive toxicity from ToxCast high throughput screening.

Quantitative high-throughput screening: a titration-based approach that efficiently identifies biological activities in large chemical libraries.

Compound cytotoxicity profiling using quantitative high-throughput screening.

A robotic platform for quantitative high-throughput screening

In vitro screening of environmental chemicals for targeted testing prioritization: the ToxCast project

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716-723

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3272593

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10.1016/J.DRUDIS.2013.05.015

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15-16

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18

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Christopher P Austin

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2013-05-31T00:00:00Z

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237016393

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23732176

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3771082

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