Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress - Wikidata - thesis-toulmin - TriplyDB

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

http://www.wikidata.org/entity/Q27305291

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Ubiquitin phosphorylation in Parkinson's disease: Implications for pathogenesis and treatment Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy Expanding the ubiquitin code through post-translational modification Simple, Scalable Proteomic Imaging for High-Dimensional Profiling of Intact Systems Mitochondrial DNA and primary mitochondrial dysfunction in Parkinson's disease.Understanding the susceptibility of dopamine neurons to mitochondrial stressors in Parkinson's disease.The ubiquitin signal and autophagy: an orchestrated dance leading to mitochondrial degradation The Mitochondrial Basis of Aging.Mechanisms of Selective Autophagy in Normal Physiology and Cancer Autophagy provides metabolic substrates to maintain energy charge and nucleotide pools in Ras-driven lung cancer cells.Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila.Seeking an In Vivo Neuronal Context for the PINK1/Parkin Pathway.PINK1, Parkin, and Mitochondrial Quality Control: What can we Learn about Parkinson's Disease Pathobiology?PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window.Structural studies of parkin and sacsin: Mitochondrial dynamics in neurodegenerative diseases.Parkin-dependent mitophagy in the heart.Mitochondria and Cancer.Roles of mitophagy in cellular physiology and development.Parkin and mitophagy in cancer.Defects in trafficking bridge Parkinson's disease pathology and genetics.Mitophagy in neurodegeneration and aging.Twenty years since the discovery of the parkin gene.Progress toward an integrated understanding of Parkinson's disease.Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway.Mitochondria in the context of Parkinson's disease.PINK1 Primes Parkin-Mediated Ubiquitination of PARIS in Dopaminergic Neuronal Survival.Hexokinases link DJ-1 to the PINK1/parkin pathway.The Mitochondrial Basis of Aging and Age-Related Disorders.The mitochondrial UPR: mechanisms, physiological functions and implications in ageing.Mitochondrial targeted HSP90 inhibitor Gamitrinib-TPP (G-TPP) induces PINK1/Parkin-dependent mitophagy.Mitochondrial DNA depletion by ethidium bromide decreases neuronal mitochondrial creatine kinase: Implications for striatal energy metabolism.Autophagy impairment in Parkinson's disease.Lack of Parkin anticipates the phenotype and affects mitochondrial morphology and mtDNA levels in a mouse model of Parkinson's Disease.Mammalian mitophagy - from in vitro molecules to in vivo models.Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture.Alpha Lipoamide Ameliorates Motor Deficits and Mitochondrial Dynamics in the Parkinson's Disease Model Induced by 6-Hydroxydopamine.Mechanism and regulation of the Lys6-selective deubiquitinase USP30.Mitochondrial fission facilitates the selective mitophagy of protein aggregates.Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand.Shedding light on mitophagy in neurons: what is the evidence for PINK1/Parkin mitophagy in vivo?

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Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

http://www.wikidata.org/entity/Q27305291

description

2015 nî lūn-bûn

@nan

2015 թուականի Յուլիսին հրատարակուած գիտական յօդուած

@hyw

2015 թվականի հուլիսին հրատարակված գիտական հոդված

@hy

2015年の論文

@ja

2015年論文

@yue

2015年論文

@zh-hant

2015年論文

@zh-hk

2015年論文

@zh-mo

2015年論文

@zh-tw

2015年论文

@wuu

name

Endogenous Parkin Preserves Do ...... chondrial DNA Mutagenic Stress

@ast

Endogenous Parkin Preserves Do ...... chondrial DNA Mutagenic Stress

@en

Endogenous Parkin Preserves Do ...... chondrial DNA Mutagenic Stress

@nl

type

label

Endogenous Parkin Preserves Do ...... chondrial DNA Mutagenic Stress

@ast

Endogenous Parkin Preserves Do ...... chondrial DNA Mutagenic Stress

@en

Endogenous Parkin Preserves Do ...... chondrial DNA Mutagenic Stress

@nl

prefLabel

Endogenous Parkin Preserves Do ...... chondrial DNA Mutagenic Stress

@ast

Endogenous Parkin Preserves Do ...... chondrial DNA Mutagenic Stress

@en

Endogenous Parkin Preserves Do ...... chondrial DNA Mutagenic Stress

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J.NEURON.2015.06.034

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Endogenous Parkin Preserves Do ...... chondrial DNA Mutagenic Stress

@en

P2093

Chiu-Hui Huang

http://www.w3.org/2001/XMLSchema#string

Dionisia P Sideris

http://www.w3.org/2001/XMLSchema#string

Jake G Hoekstra

http://www.w3.org/2001/XMLSchema#string

Richard J Youle

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Scott R Kennedy

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P2860

PINK1 is selectively stabilized on impaired mitochondria to activate Parkin

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

Premature ageing in mice expressing defective mitochondrial DNA polymerase

PARIS (ZNF746) repression of PGC-1α contributes to neurodegeneration in Parkinson's disease

Ubiquitin is phosphorylated by PINK1 to activate parkin

The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO

Quantifying ubiquitin signaling

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scholarly article

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10.1016/J.NEURON.2015.06.034

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2

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87

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Alicia M Pickrell

Jeffrey W. Harper

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2015-07-01T00:00:00Z

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26182419

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mitochondrial DNA

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4803114

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