Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress - Wikidata - thesis-toulmin - TriplyDB

Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress

Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress

http://www.wikidata.org/entity/Q27334909

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Phosphoproteomics reveals malaria parasite Protein Kinase G as a signalling hub regulating egress and invasion.Parasite Calcineurin Regulates Host Cell Recognition and Attachment by Apicomplexans Using a Genetically Encoded Sensor to Identify Inhibitors of Toxoplasma gondii Ca2+ Signaling.The Conoid Associated Motor MyoH Is Indispensable for Toxoplasma gondii Entry and Exit from Host Cells An essential malaria protein defines the architecture of blood-stage and transmission-stage parasites.The malaria parasite egress protease SUB1 is a calcium-dependent redox switch subtilisin A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs The central role of cAMP in regulating Plasmodium falciparum merozoite invasion of human erythrocytes Cyclic GMP balance is critical for malaria parasite transmission from the mosquito to the mammalian host Host cell remodeling by pathogens: the exomembrane system in Plasmodium-infected erythrocytes The malarial serine protease SUB1 plays an essential role in parasite liver stage development Development of a transgenic Plasmodium berghei line (Pb pfpkg) expressing the P. falciparum cGMP-dependent protein kinase, a novel antimalarial drug target Phosphoinositide metabolism links cGMP-dependent protein kinase G to essential Ca²⁺ signals at key decision points in the life cycle of malaria parasites Plasmodium falciparum transfected with ultra bright NanoLuc luciferase offers high sensitivity detection for the screening of growth and cellular trafficking inhibitors Crystal structures of the carboxyl cGMP binding domain of the Plasmodium falciparum cGMP-dependent protein kinase reveal a novel capping triad crucial for merozoite egress Identification of a Plasmodium falciparum phospholipid transfer protein Plasmodium falciparum CRK4 directs continuous rounds of DNA replication during schizogony Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle Serum Albumin Stimulates Protein Kinase G-dependent Microneme Secretion in Toxoplasma gondii Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress.The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes.Membrane-wrapping contributions to malaria parasite invasion of the human erythrocyte The calcium-dependent protein kinase 3 of toxoplasma influences basal calcium levels and functions beyond egress as revealed by quantitative phosphoproteome analysis Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion.Molecular modeling, in silico screening and molecular dynamics of PfPRL-PTP of P. falciparum for identification of potential anti-malarials.Structural and evolutionary divergence of cyclic nucleotide binding domains in eukaryotic pathogens: Implications for drug design Localisation-based imaging of malarial antigens during erythrocyte entry reaffirms a role for AMA1 but not MTRAP in invasion A key role for Plasmodium subtilisin-like SUB1 protease in egress of malaria parasites from host hepatocytes.Reduced Activity of Mutant Calcium-Dependent Protein Kinase 1 Is Compensated in Plasmodium falciparum through the Action of Protein Kinase G.In silico study of subtilisin-like protease 1 (SUB1) from different Plasmodium species in complex with peptidyl-difluorostatones and characterization of potent pan-SUB1 inhibitors Expression of the essential Kinase PfCDPK1 from Plasmodium falciparum in Toxoplasma gondii facilitates the discovery of novel antimalarial drugs Post-translational protein modifications in malaria parasites.Designing selective inhibitors for calcium-dependent protein kinases in apicomplexans.Calcium signalling in malaria parasites.Molecular Signaling Involved in Entry and Exit of Malaria Parasites from Host Erythrocytes.Proteases as antimalarial targets: strategies for genetic, chemical, and therapeutic validation.The single cyclic nucleotide-specific phosphodiesterase of the intestinal parasite Giardia lamblia represents a potential drug target.A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.Gliding motility powers invasion and egress in Apicomplexa.

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P2860

Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress

http://www.wikidata.org/entity/Q27334909

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2013 nî lūn-bûn

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2013 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2013年の論文

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2013年論文

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Chrislaine Withers-Martinez

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Christine R Collins

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Fiona Hackett

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Maria Penzo

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Michael J Blackman

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P2860

Molecular identification of a malaria merozoite surface sheddase

Distinct external signals trigger sequential release of apical organelles during erythrocyte invasion by malaria parasites

Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase

A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes

A subtilisin-like protein in secretory organelles of Plasmodium falciparum merozoites

Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytes

A multifunctional serine protease primes the malaria parasite for red blood cell invasion

PfPDE1, a novel cGMP-specific phosphodiesterase from the human malaria parasite Plasmodium falciparum

Rapid membrane disruption by a perforin-like protein facilitates parasite exit from host cells.

Irreversible effect of cysteine protease inhibitors on the release of malaria parasites from infected erythrocytes

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cGMP-dependent protein kinase

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