Molecular Mechanism of a Thumb Domain Hepatitis C Virus Nonnucleoside RNA-Dependent RNA Polymerase Inhibitor
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Using the Hepatitis C Virus RNA-Dependent RNA Polymerase as a Model to Understand Viral Polymerase Structure, Function and DynamicsPhenotypic Characterization of Resistant Val36 Variants of Hepatitis C Virus NS3-4A Serine ProteaseIn Vitro Resistance Study of AG-021541, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA PolymeraseA Locking Mechanism Regulates RNA Synthesis and Host Protein Interaction by the Hepatitis C Virus PolymeraseMolecular Mechanism of Hepatitis C Virus Replicon Variants with Reduced Susceptibility to a Benzofuran Inhibitor, HCV-796Development of Intergenotypic Chimeric Replicons To Determine the Broad-Spectrum Antiviral Activities of Hepatitis C Virus Polymerase InhibitorsSelected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479Selection and Characterization of Hepatitis C Virus Replicons Dually Resistant to the Polymerase and Protease Inhibitors HCV-796 and Boceprevir (SCH 503034)Preclinical Characterization of PF-00868554, a Potent Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA PolymeraseSlow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C VirusPreclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA PolymeraseInitiation of RNA synthesis by the hepatitis C virus RNA-dependent RNA polymerase is affected by the structure of the RNA template.Autophagy protein ATG5 interacts transiently with the hepatitis C virus RNA polymerase (NS5B) early during infectionTherapeutic implications of hepatitis C virus resistance to antiviral drugs.Affinity labeling of hepatitis C virus replicase with a nucleotide analogue: identification of binding site.Resistance mechanisms in HCV: from evolution to intervention.Recent advances in the development of NS5B polymerase inhibitors for the treatment of hepatitis C virus infection.Dynamic evolution of hepatitis C virus resistance-associated substitutions in the absence of antiviral treatment.Non-nucleoside inhibitors of hepatitis C virus polymerase: current progress and future challenges.Antiviral therapy for hepatitis C virus: beyond the standard of care.Hepatitis C virus resistance to new specifically-targeted antiviral therapy: A public health perspective.Biochemical study of the comparative inhibition of hepatitis C virus RNA polymerase by VX-222 and filibuvir.Effect of D168V mutation in NS3/4A HCV protease on susceptibilities of faldaprevir and danoprevir.Structural and regulatory elements of HCV NS5B polymerase--β-loop and C-terminal tail--are required for activity of allosteric thumb site II inhibitors.Prevalence of hepatitis C virus-resistant association substitutions to direct-acting antiviral agents in treatment-naïve hepatitis C genotype 1b-infected patients in western China.
P2860
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P2860
Molecular Mechanism of a Thumb Domain Hepatitis C Virus Nonnucleoside RNA-Dependent RNA Polymerase Inhibitor
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2006 nî lūn-bûn
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2006 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
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2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Molecular Mechanism of a Thumb ...... ndent RNA Polymerase Inhibitor
@ast
Molecular Mechanism of a Thumb ...... ndent RNA Polymerase Inhibitor
@en
Molecular Mechanism of a Thumb ...... ndent RNA Polymerase Inhibitor
@nl
type
label
Molecular Mechanism of a Thumb ...... ndent RNA Polymerase Inhibitor
@ast
Molecular Mechanism of a Thumb ...... ndent RNA Polymerase Inhibitor
@en
Molecular Mechanism of a Thumb ...... ndent RNA Polymerase Inhibitor
@nl
prefLabel
Molecular Mechanism of a Thumb ...... ndent RNA Polymerase Inhibitor
@ast
Molecular Mechanism of a Thumb ...... ndent RNA Polymerase Inhibitor
@en
Molecular Mechanism of a Thumb ...... ndent RNA Polymerase Inhibitor
@nl
P2093
P2860
P356
P1476
Molecular Mechanism of a Thumb ...... ndent RNA Polymerase Inhibitor
@en
P2093
Alfred M Del Vecchio
Anita Y M Howe
Atul Agarwal
Huiming Cheng
Ian Thompson
John O'Connell
Rajiv Chopra
Srinivas K Chunduru
Steve Herrmann
P2860
P304
P356
10.1128/AAC.00365-06
P407
P577
2006-12-01T00:00:00Z