Two different neurodegenerative diseases caused by proteins with similar structures
about
Doppel-induced cerebellar degeneration in transgenic micePrion-like protein Doppel expression is not modified in scrapie-infected cells and in the brains of patients with Creutzfeldt-Jakob diseaseThe human "prion-like" protein Doppel is expressed in both Sertoli cells and spermatozoaPrion protein paralog doppel protein interacts with alpha-2-macroglobulin: a plausible mechanism for doppel-mediated neurodegenerationEvolutionary descent of prion genes from the ZIP family of metal ion transportersThe PrP-like protein Doppel binds copperComparative genomic analysis of prion genesThe prion protein modulates A-type K+ currents mediated by Kv4.2 complexes through dipeptidyl aminopeptidase-like protein 6Enhanced stability of human prion proteins with two disulfide bridges.Copper(II) binding to the human Doppel protein may mark its functional diversity from the prion protein.Similar folds with different stabilization mechanisms: the cases of Prion and Doppel proteins.Doppel and PrPC co-immunoprecipitate in detergent-resistant membrane domains of epithelial FRT cellsNormal neurogenesis and scrapie pathogenesis in neural grafts lacking the prion protein homologue DoppelThe N-terminal, polybasic region is critical for prion protein neuroprotective activity.Absence of the prion protein homologue Doppel causes male sterility.Protease-resistant prions selectively decrease Shadoo protein.Biochemical signatures of doppel protein in human astrocytomas to support prediction in tumor malignancy.Prion and doppel proteins bind to granule cells of the cerebellumAge-dependent impairment of eyeblink conditioning in prion protein-deficient mice.A strategy for synthesis of pathogenic human immunoglobulin free light chains in E. coli.Prion protein misfolding.Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout miceStructural defects and the diagnosis of amyloidogenic propensityDid the prion protein become vulnerable to misfolding after an evolutionary divide and conquer event?Cellular prion protein: from physiology to pathology.Comparative computational analysis of prion proteins reveals two fragments with unusual structural properties and a pattern of increase in hydrophobicity associated with disease-promoting mutations.Monomeric Aβ(1-40) and Aβ(1-42) Peptides in Solution Adopt Very Similar Ramachandran Map Distributions That Closely Resemble Random Coil.Molecular basis of cerebral neurodegeneration in prion diseases.Prion neurotoxicity: insights from prion protein mutantsTransgene-driven expression of the Doppel protein in Purkinje cells causes Purkinje cell degeneration and motor impairmentAntagonistic roles of the N-terminal domain of prion protein to doppel.A structural overview of the vertebrate prion proteins.Disruption of Doppel prevents neurodegeneration in mice with extensive Prnp deletions.Prion proteins with pathogenic and protective mutations show similar structure and dynamics.Disruption of glycosylation enhances ubiquitin-mediated proteasomal degradation of Shadoo in Scrapie-infected rodents and cultured cells.Endoproteolytic processing of the mammalian prion glycoprotein family.Expression of truncated PrP targeted to Purkinje cells of PrP knockout mice causes Purkinje cell death and ataxia.alpha-Helical domains promote translocation of intrinsically disordered polypeptides into the endoplasmic reticulumThe CNS glycoprotein Shadoo has PrP(C)-like protective properties and displays reduced levels in prion infections.Folding pathways of prion and doppel.
P2860
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P2860
Two different neurodegenerative diseases caused by proteins with similar structures
description
2001 nî lūn-bûn
@nan
2001 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Two different neurodegenerative diseases caused by proteins with similar structures
@ast
Two different neurodegenerative diseases caused by proteins with similar structures
@en
Two different neurodegenerative diseases caused by proteins with similar structures
@nl
type
label
Two different neurodegenerative diseases caused by proteins with similar structures
@ast
Two different neurodegenerative diseases caused by proteins with similar structures
@en
Two different neurodegenerative diseases caused by proteins with similar structures
@nl
prefLabel
Two different neurodegenerative diseases caused by proteins with similar structures
@ast
Two different neurodegenerative diseases caused by proteins with similar structures
@en
Two different neurodegenerative diseases caused by proteins with similar structures
@nl
P2093
P2860
P356
P1476
Two different neurodegenerative diseases caused by proteins with similar structures
@en
P2093
P2860
P304
P356
10.1073/PNAS.051627998
P407
P577
2001-02-27T00:00:00Z