Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids
about
The amylase inhibitor montbretin A reveals a new glycosidase inhibition motifAn association-adjusted consensus deleterious scheme to classify homozygous Mis-sense mutations for personal genome interpretationMechanistic investigation of the endo-alpha-N-acetylgalactosaminidase from Streptococcus pneumoniae R6.ASD v3.0: unraveling allosteric regulation with structural mechanisms and biological networks.Calculating pKa values in enzyme active sites.Potent Human α-Amylase Inhibition by the β-Defensin-like Protein Helianthamide.Structural and mechanistic studies of chloride induced activation of human pancreatic alpha-amylase.In situ extension as an approach for identifying novel alpha-amylase inhibitors.Human salivary alpha-amylase Trp58 situated at subsite -2 is critical for enzyme activity.Identification of catalytic residues of Ca2+-independent 1,2-alpha-D-mannosidase from Aspergillus saitoi by site-directed mutagenesis.Entropy and free energy of a mobile protein loop in explicit water.Structure of human salivary alpha-amylase crystallized in a C-centered monoclinic space groupReplacement of the catalytic nucleophile aspartyl residue of dextran glucosidase by cysteine sulfinate enhances transglycosylation activity.Acid-base catalysis in Leuconostoc mesenteroides sucrose phosphorylase probed by site-directed mutagenesis and detailed kinetic comparison of wild-type and Glu237-->Gln mutant enzymesIdentification of the catalytic nucleophile of the family 29 alpha-L-fucosidase from Thermotoga maritima through trapping of a covalent glycosyl-enzyme intermediate and mutagenesis.Improvement of the acid stability of Bacillus licheniformis alpha amylase by error-prone PCR.Investigation of the functional relevance of the catalytically important Glu(28) in family 51 arabinosidases.Identification and characterization of a core fucosidase from the bacterium Elizabethkingia meningoseptica.Towards Tuneable Retaining Glycosidase-Inhibiting Peptides by Mimicry of a Plant Flavonol Warhead.Dissecting differential binding of fructose and phosphate as leaving group/nucleophile of glucosyl transfer catalyzed by sucrose phosphorylase.Differential α-amylase/α-glucosidase inhibitory activities of plant-derived phenolic compounds: a virtual screening perspective for the treatment of obesity and diabetes.
P2860
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P2860
Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids
description
2002 nî lūn-bûn
@nan
2002 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2002年の論文
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2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Mechanistic analyses of cataly ...... ree conserved carboxylic acids
@ast
Mechanistic analyses of cataly ...... ree conserved carboxylic acids
@en
Mechanistic analyses of cataly ...... ree conserved carboxylic acids
@nl
type
label
Mechanistic analyses of cataly ...... ree conserved carboxylic acids
@ast
Mechanistic analyses of cataly ...... ree conserved carboxylic acids
@en
Mechanistic analyses of cataly ...... ree conserved carboxylic acids
@nl
prefLabel
Mechanistic analyses of cataly ...... ree conserved carboxylic acids
@ast
Mechanistic analyses of cataly ...... ree conserved carboxylic acids
@en
Mechanistic analyses of cataly ...... ree conserved carboxylic acids
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P2093
P356
P1433
P1476
Mechanistic analyses of cataly ...... ree conserved carboxylic acids
@en
P2093
Chunmin Li
Edwin H Rydberg
Gary D Brayer
Robert Maurus
Stephen G Withers
P304
P356
10.1021/BI011821Z
P407
P577
2002-04-02T00:00:00Z