The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53
about
A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cellsModulation of p53 activity by IkappaBalpha: evidence suggesting a common phylogeny between NF-kappaB and p53 transcription factors.In vivo binding and retention of CD4-specific DARPin 57.2 in macaquesCrystal structure of human osteoclast stimulating factorInhibition of apoptosis by oncogenic hepatitis B virus X protein: Implications for the treatment of hepatocellular carcinomaRedox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degronMechanical unfolding of an ankyrin repeat protein.Gradually elevated expression of Gankyrin during human hepatocarcinogenesis and its clinicopathological significanceGankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells.Disruption of G1-phase phospholipid turnover by inhibition of Ca2+-independent phospholipase A2 induces a p53-dependent cell-cycle arrest in G1 phase.A transcription blocker isolated from a designed repeat protein combinatorial library by in vivo functional screenIntracellular signaling and hepatocellular carcinoma.Prognostic and clinicopathological significance of Gankyrin overexpression in cancers: evidence from a meta-analysisUp-regulated oncoprotein P28GANK correlates with proliferation and poor prognosis of human glioma.Purification, crystallization and preliminary X-ray diffraction analysis of the non-ATPase subunit Nas6 in complex with the ATPase subunit Rpt3 of the 26S proteasome from Saccharomyces cerevisiae.Discovery of a small-molecule binder of the oncoprotein gankyrin that modulates gankyrin activity in the cellFunctional characterization of human oncoprotein gankyrin in Zebrafish.New targeted approaches against the ubiquitin-proteasome system in gastrointestinal malignancies.Structural basis for recognition of 2',5'-linked oligoadenylates by human ribonuclease L.MiR-605 represses PSMD10/Gankyrin and inhibits intrahepatic cholangiocarcinoma cell progression.Discovery of multiple interacting partners of gankyrin, a proteasomal chaperone and an oncoprotein--evidence for a common hot spot site at the interface and its functional relevance.Farnesoid X receptor inhibits gankyrin in mouse livers and prevents development of liver cancer.Gankyrin as a potential therapeutic target for cancer.Gankyrin oncoprotein overexpression as a critical factor for tumor growth in human esophageal squamous cell carcinoma and its clinical significance.Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.p53-independent pRB degradation contributes to a drug-induced apoptosis in AGS cells.The study of pH-dependent stability shows that the TPLH-mediated hydrogen-bonding network is important for the conformation and stability of human gankyrin.Dissection of protein-protein interaction and CDK4 inhibition in the oncogenic versus tumor suppressing functions of gankyrin and P16.Gankyrin: a novel promising therapeutic target for hepatocellular carcinoma.Gankyrin Drives Malignant Transformation of Gastric Cancer and Alleviates Oxidative Stress via mTORC1 Activation
P2860
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P2860
The crystal structure of gankyrin, an oncoprotein found in complexes with cyclin-dependent kinase 4, a 19 S proteasomal ATPase regulator, and the tumor suppressors Rb and p53
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
The crystal structure of ganky ...... e tumor suppressors Rb and p53
@ast
The crystal structure of ganky ...... e tumor suppressors Rb and p53
@en
The crystal structure of ganky ...... e tumor suppressors Rb and p53
@nl
type
label
The crystal structure of ganky ...... e tumor suppressors Rb and p53
@ast
The crystal structure of ganky ...... e tumor suppressors Rb and p53
@en
The crystal structure of ganky ...... e tumor suppressors Rb and p53
@nl
prefLabel
The crystal structure of ganky ...... e tumor suppressors Rb and p53
@ast
The crystal structure of ganky ...... e tumor suppressors Rb and p53
@en
The crystal structure of ganky ...... e tumor suppressors Rb and p53
@nl
P2093
P2860
P3181
P356
P1476
The crystal structure of ganky ...... e tumor suppressors Rb and p53
@en
P2093
Andrzej M Brzozowski
Hiroaki Higashitsuji
Jun Fujita
R John Mayer
Rebecca Welchman
Simon Dawson
P2860
P304
P3181
P356
10.1074/JBC.M310265200
P407
P577
2003-10-22T00:00:00Z