Structural and molecular basis of the assembly of the TRPP2/PKD1 complex
about
The stoichiometry and biophysical properties of the Kv4 potassium channel complex with K+ channel-interacting protein (KChIP) subunits are variable, depending on the relative expression levelA polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexesMultiple C-terminal tail Ca(2+)/CaMs regulate Ca(V)1.2 function but do not mediate channel dimerizationStructural and functional similarities of calcium homeostasis modulator 1 (CALHM1) ion channel with connexins, pannexins, and innexinsDirect recording and molecular identification of the calcium channel of primary cilia.International Union of Basic and Clinical Pharmacology. LXXVI. Current progress in the mammalian TRP ion channel familyThe functions of TRPP2 in the vascular systemA polycystin-centric view of cyst formation and disease: the polycystins revisitedPhotophysics of fluorescent probes for single-molecule biophysics and super-resolution imagingStructure of the EF-hand domain of polycystin-2 suggests a mechanism for Ca2+-dependent regulation of polycystin-2 channel activityMolecular mechanism for 3:1 subunit stoichiometry of rod cyclic nucleotide-gated ion channelsGating of the designed trimeric/tetrameric voltage-gated H+channelMolecular mechanism of the assembly of an acid-sensing receptor ion channel complex.Molecular Bases of Multimodal Regulation of a Fungal Transient Receptor Potential (TRP) ChannelThe number and location of EF hand motifs dictates the calcium dependence of polycystin-2 functionPkd1l1 establishes left-right asymmetry and physically interacts with Pkd2.Osteoblast-specific deletion of Pkd2 leads to low-turnover osteopenia and reduced bone marrow adiposityStoichiometry of the KCNQ1 - KCNE1 ion channel complex.A genetic interaction network of five genes for human polycystic kidney and liver diseases defines polycystin-1 as the central determinant of cyst formationIdentification of the structural motif responsible for trimeric assembly of the C-terminal regulatory domains of polycystin channels PKD2L1 and PKD2Nicotinamide is an endogenous agonist for a C. elegans TRPV OSM-9 and OCR-4 channel.Heteromerization of TRP channel subunits: extending functional diversityFunction and regulation of TRPP2 ion channel revealed by a gain-of-function mutantMolecular insights into lipid-assisted Ca(2+) regulation of the TRP channel Polycystin-2Molecular architecture and subunit organization of TRPA1 ion channel revealed by electron microscopyAssembly stoichiometry of the GluK2/GluK5 kainate receptor complex.AMPA receptor/TARP stoichiometry visualized by single-molecule subunit countingTransient receptor potential (TRP) channels: a clinical perspectiveMolecular advances in autosomal dominant polycystic kidney disease.Genetic mechanisms and signaling pathways in autosomal dominant polycystic kidney disease.Polycystin-2 activation by inositol 1,4,5-trisphosphate-induced Ca2+ release requires its direct association with the inositol 1,4,5-trisphosphate receptor in a signaling microdomain.Atomic force microscopy reveals the alternating subunit arrangement of the TRPP2-TRPV4 heterotetramer.The cell biology of polycystic kidney diseaseOligomeric state of purified transient receptor potential melastatin-1 (TRPM1), a protein essential for dim light vision.Hyperphosphorylation of polycystin-2 at a critical residue in disease reveals an essential role for polycystin-1-regulated dephosphorylation.Oligomerization of the polycystin-2 C-terminal tail and effects on its Ca2+-binding propertiesMacromolecular assembly of polycystin-2 intracytosolic C-terminal domain.Structural model of the TRPP2/PKD1 C-terminal coiled-coil complex produced by a combined computational and experimental approach.Deciphering physiological role of the mechanosensitive TRPV4 channel in the distal nephron.Altered trafficking and stability of polycystins underlie polycystic kidney disease.
P2860
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P2860
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex
@ast
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex
@en
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex
@nl
type
label
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex
@ast
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex
@en
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex
@nl
prefLabel
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex
@ast
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex
@en
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex
@nl
P2093
P2860
P3181
P356
P1476
Structural and molecular basis of the assembly of the TRPP2/PKD1 complex
@en
P2093
Albert C M Ong
Ehud Y Isacoff
Maximilian H Ulbrich
Ming-Hui Li
Xing-Zhen Chen
Zafir Buraei
P2860
P304
11558-11563
P3181
P356
10.1073/PNAS.0903684106
P407
P577
2009-06-25T00:00:00Z