about
Enantioselective alpha-trifluoromethylation of aldehydes via photoredox organocatalysisFormation of ArF from LPdAr(F): catalytic conversion of aryl triflates to aryl fluoridesStandard protecting groups create potent and selective kappa opioids: salvinorin B alkoxymethyl ethersAntidepressant specificity of serotonin transporter suggested by three LeuT-SSRI structuresMethods to Increase the Metabolic Stability of (18)F-RadiotracersInsights into the mechanism of bovine CD38/NAD+glycohydrolase from the X-ray structures of its Michaelis complex and covalently-trapped intermediatesXModeScore: a novel method for accurate protonation/tautomer-state determination using quantum-mechanically driven macromolecular X-ray crystallographic refinement.Detailed insights from microarray and crystallographic studies into carbohydrate recognition by microneme protein 1 (MIC1) ofToxoplasma gondiiFluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing mannerStructural Evaluation of Potent NKT Cell Agonists: Implications for Design of Novel Stimulatory LigandsThermodynamic optimisation in drug discovery: a case study using carbonic anhydrase inhibitorsHalogenated β,γ-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase β: Structural Evidence for Stereospecific Binding of the Fluoromethylene AnaloguesStructural and Biochemical Studies of a Fluoroacetyl-CoA-Specific Thioesterase Reveal a Molecular Basis for Fluorine SelectivityProtein Flexibility and Conformational Entropy in Ligand Design Targeting the Carbohydrate Recognition Domain of Galectin-3Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNAMapping the Reaction Coordinates of Enzymatic DefluorinationMolecular recognition at the active site of catechol-O-methyltransferase (COMT): adenine replacements in bisubstrate inhibitorsFluoroalkyl and Alkyl Chains Have Similar Hydrophobicities in Binding to the “Hydrophobic Wall” of Carbonic AnhydraseInsights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands to α4β2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia.Exhaustive Fluorine Scanning toward Potent p53-Mdm2 AntagonistsMolecular recognition at the active site of factor Xa: cation-π interactions, stacking on planar peptide surfaces, and replacement of structural waterA Novel Mechanism by Which Small Molecule Inhibitors Induce the DFG Flip in Aurora AInhibition of dd -Peptidases by a Specific Trifluoroketone: Crystal Structure of a Complex with the Actinomadura R39 dd -PeptidaseCatechol-O-methyltransferase in complex with substituted 3'-deoxyribose bisubstrate inhibitorsStructural basis for the enhanced stability of highly fluorinated proteinsStructural and Biochemical Characterization of Compounds Inhibiting Mycobacterium tuberculosis Pantothenate KinaseDevelopment of New Deoxycytidine Kinase Inhibitors and Noninvasive in Vivo Evaluation Using Positron Emission TomographyAn Ultrahigh Affinity d -Peptide Antagonist Of MDM2Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding SiteFluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase InhibitorsCatalysis for fluorination and trifluoromethylationAddressing the Glycine-Rich Loop of Protein Kinases by a Multi-Facetted Interaction Network: Inhibition of PKA and a PKB MimicGalectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan RecognitionA Chemical Probe for the ATAD2 BromodomainA Modified P1 Moiety Enhances in vitro Antiviral Activity against Various Multi-Drug-Resistant HIV-1 Variants and in vitro CNS Penetration Properties of a Novel Nonpeptidic Protease Inhibitor, GRL-10413Directed Evolution of a Fluorinase for Improved Fluorination Efficiency with a Non-native SubstrateLate-Stage Fluorination: From Fundamentals to ApplicationA trifluorinated thiazoline scaffold leading to pro-apoptotic agents targeting prohibitinsTotal synthesis and biological evaluation of fluorinated cryptophycins
P2860
Q24611935-EBC1C608-A145-4F7F-8D1B-5A645F5C7EFAQ24626698-2B2DD89F-096D-462C-B733-7E7B2203EC77Q24651427-3E2EA7A0-4D66-411C-A80C-87E732CD2578Q24655640-46F10708-B7D7-4D95-80AA-6431235FCEBCQ26781407-E84635EF-4B2E-42A6-AD33-406793E43645Q27304847-262A9BBB-D482-43D6-B981-3696615E133AQ27316736-6B7960B2-F967-4A47-90E2-359F4E05E8CDQ27646533-0D7E83D2-2E87-4993-A69C-F21B86373204Q27657120-2B809AF7-AA8F-40C5-9A81-4E416D212057Q27657337-DDACEC0B-57C7-481E-BCDF-B13E7B65B71BQ27658036-13CA9E1F-9828-49C5-9488-DA7D6C523D7BQ27661593-F3EFAB54-E724-47EA-9BF2-8E5B13AD1B45Q27664447-AF6C2EB5-4428-4707-AF4C-062FDB7AAD46Q27664681-BE1EFF40-C24F-4294-B9DA-068BF2927E24Q27666501-ED21090B-6733-4AEC-A59C-C5FC11B8D6B2Q27667511-FF54782F-4A1D-4EDC-9078-35404F563BE9Q27667660-DEE1033E-895C-4282-8EAC-A358A59C1669Q27671014-3FFFB4F5-E32E-4CCB-8F58-6A63B3EECAF1Q27671769-A8122D98-6730-4F66-BDA4-5682B2472FE5Q27671806-1F0D5387-2914-4AF3-ACD4-85B6F6725261Q27674554-69E94296-2D5C-437F-8709-7B31AE971245Q27676143-55D26BAB-F2BB-4AC2-A1C4-ACD7886C5F59Q27676768-4B4D0DAD-6848-4BE7-9C84-696DD1E1CDAEQ27676788-F9B4F0A4-E0BF-49CC-B72D-CF90402CD199Q27677370-034FBFAC-8435-465C-B3EB-995B90AEAFBEQ27678017-87ABBDB0-6D68-4825-B373-FD4326229949Q27678080-2D0FF071-BF30-4231-B0C2-10C35D26CD39Q27679693-FF69567E-3FD1-4062-A115-20E62B187ABAQ27681154-E6576E05-6D9C-4AA2-A4F5-F86D11ACB764Q27681568-E8434204-4519-4E0D-9BDD-6ED489C27608Q27683656-4F15A9E1-311A-47E7-A6D6-EA87E524D124Q27687352-251ABDA7-9FCC-496E-B3AA-5BB1EA842FFBQ27702642-11912D8A-1985-4A73-B677-729E57B6569EQ27714964-6FCA3000-9F8C-48C2-8DCD-21D77E5A4DDFQ27727700-DB636CF0-8338-4E01-92BD-1700658A0964Q27728053-94A69059-62B7-4F89-91CB-42269F67A3FEQ27728471-3A2DBB51-5B95-41B4-9069-4CC307463162Q28088592-79D3354F-53EE-4EF8-9085-732A994D22DEQ28247417-113DB110-02E5-46A6-8AAB-0C598598D85DQ28280644-5176B73E-9AAF-4697-92D7-5D16C20DD75F
P2860
description
2007 nî lūn-bûn
@nan
2007 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Fluorine in pharmaceuticals: looking beyond intuition
@ast
Fluorine in pharmaceuticals: looking beyond intuition
@en
Fluorine in pharmaceuticals: looking beyond intuition
@nl
type
label
Fluorine in pharmaceuticals: looking beyond intuition
@ast
Fluorine in pharmaceuticals: looking beyond intuition
@en
Fluorine in pharmaceuticals: looking beyond intuition
@nl
prefLabel
Fluorine in pharmaceuticals: looking beyond intuition
@ast
Fluorine in pharmaceuticals: looking beyond intuition
@en
Fluorine in pharmaceuticals: looking beyond intuition
@nl
P3181
P356
P1433
P1476
Fluorine in pharmaceuticals: looking beyond intuition
@en
P2093
Christoph Faeh
Klaus Müller
P2860
P304
P3181
P356
10.1126/SCIENCE.1131943
P407
P577
2007-09-28T00:00:00Z