Structural and Functional Characterization of the Human Protein Kinase ASK1
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The roles of ASK family proteins in stress responses and diseasesAMPK phosphorylation of raptor mediates a metabolic checkpointJNK Signaling: Regulation and Functions Based on Complex Protein-Protein PartnershipsTherapeutic targets in the ASK1-dependent stress signaling pathwaysRas Homolog Enriched in Brain (Rheb) Enhances Apoptotic SignalingCrystal structures of ASK1-inhibtor complexes provide a platform for structure-based drug designChloride Sensing by WNK1 Involves Inhibition of AutophosphorylationDeciphering the Arginine-binding preferences at the substrate-binding groove of Ser/Thr kinases by computational surface mappingDifferential regulation of PKD isoforms in oxidative stress conditions through phosphorylation of a conserved Tyr in the P+1 loop.Mutant p53 disrupts the stress MAPK activation circuit induced by ASK1-dependent stabilization of Daxx.Inhibition of JNK and p38 MAPK phosphorylation by 5-(acetylamino)-4-oxo-6-phenyl-2-hexenoic acid methyl ester and 4-phenyl-butenoic acid decreases substance P-induced TNF-α upregulation in macrophagesCarbamoylating activity associated with the activation of the antitumor agent laromustine inhibits angiogenesis by inducing ASK1-dependent endothelial cell deathTheoretical investigation on structural, functional and epitope of a 12 kDa excretory-secretory protein from Toxoplasma gondii.Role of apoptosis signal-regulating kinase 1 (ASK1) as an activator of the GAPDH-Siah1 stress-signaling cascade.Phenothiazine Inhibitors of TLKs Affect Double-Strand Break Repair and DNA Damage Response Recovery and Potentiate Tumor Killing with Radiomimetic Therapy.Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing.Thioredoxin and thioredoxin target proteins: from molecular mechanisms to functional significance.Aberrant Activation of p38 MAP Kinase-Dependent Innate Immune Responses Is Toxic to Caenorhabditis elegans.Cross-talk between Arg methylation and Ser phosphorylation modulates apoptosis signal-regulating kinase 1 activation in endothelial cells.Precisely ordered phosphorylation reactions in the p38 mitogen-activated protein (MAP) kinase cascadeFunctional divergence and evolutionary turnover in mammalian phosphoproteomes.Targeting the unactivated conformations of protein kinases for small molecule drug discovery.Regulatory roles of conserved phosphorylation sites in the activation T-loop of the MAP kinase ERK1MLK3 is part of a feedback mechanism that regulates different cellular responses to reactive oxygen species.JAK2 and SHP2 reciprocally regulate tyrosine phosphorylation and stability of proapoptotic protein ASK1.Structural Insight into the 14-3-3 Protein-dependent Inhibition of Protein Kinase ASK1 (Apoptosis Signal-regulating kinase 1).Structural basis of autoregulatory scaffolding by apoptosis signal-regulating kinase 1.Biophysical and structural characterization of the thioredoxin-binding domain of protein kinase ASK1 and its interaction with reduced thioredoxinHow does arrestin assemble MAPKs into a signaling complex?OncoPPi-informed discovery of mitogen-activated protein kinase kinase 3 as a novel binding partner of c-Myc.ASK family in cardiovascular biology and medicine.Computational insight into p21-activated kinase 4 inhibition: a combined ligand- and structure-based approach.Kinase crystal identification and ATP-competitive inhibitor screening using the fluorescent ligand SKF86002.
P2860
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P2860
Structural and Functional Characterization of the Human Protein Kinase ASK1
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Structural and Functional Characterization of the Human Protein Kinase ASK1
@ast
Structural and Functional Characterization of the Human Protein Kinase ASK1
@en
Structural and Functional Characterization of the Human Protein Kinase ASK1
@nl
type
label
Structural and Functional Characterization of the Human Protein Kinase ASK1
@ast
Structural and Functional Characterization of the Human Protein Kinase ASK1
@en
Structural and Functional Characterization of the Human Protein Kinase ASK1
@nl
prefLabel
Structural and Functional Characterization of the Human Protein Kinase ASK1
@ast
Structural and Functional Characterization of the Human Protein Kinase ASK1
@en
Structural and Functional Characterization of the Human Protein Kinase ASK1
@nl
P2093
P2860
P50
P921
P1433
P1476
Structural and Functional Characterization of the Human Protein Kinase ASK1
@en
P2093
Benjamin E Turk
Gabor Bunkoczi
Haifeng Zhang
Sirlester A Parker
P2860
P304
P356
10.1016/J.STR.2007.08.011
P577
2007-10-01T00:00:00Z