Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation - Wikidata - thesis-toulmin - TriplyDB

Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation

Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation

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Evolution of SH2 domains and phosphotyrosine signalling networks Structural insight into the human immunodeficiency virus Vif SOCS box and its role in human E3 ubiquitin ligase assembly The biology and mechanism of action of suppressor of cytokine signaling 3 The role of suppressors of cytokine signalling in human neoplasms The SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin Ligase Structural Basis for c-KIT Inhibition by the Suppressor of Cytokine Signaling 6 (SOCS6) Ubiquitin Ligase Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases Molecular Architecture of the Ankyrin SOCS Box Family of Cul5-Dependent E3 Ubiquitin Ligases Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction Structural basis of intersubunit recognition in elongin BC-cullin 5-SOCS box ubiquitin-protein ligase complexes The SH2 domain-containing proteins in 21 species establish the provenance and scope of phosphotyrosine signaling in eukaryotes The SOCS-box of HIV-1 Vif interacts with ElonginBC by induced-folding to recruit its Cul5-containing ubiquitin ligase complex Molecular insight into the conformational dynamics of the Elongin BC complex and its interaction with HIV-1 Vif.Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.The mechanism of ubiquitination in the cullin-RING E3 ligase machinery: conformational control of substrate orientation Molecular dynamics reveal the essential role of linker motions in the function of cullin-RING E3 ligases Why does binding of proteins to DNA or proteins to proteins not necessarily spell function?Reconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates.Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation.Insights into Cullin-RING E3 ubiquitin ligase recruitment: structure of the VHL-EloBC-Cul2 complex Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.Expression of suppressor of cytokine signaling genes in human elderly and Alzheimer's disease brains and human microglia Flexible cullins in cullin-RING E3 ligases allosterically regulate ubiquitination.Drosophila SOCS Proteins.A mechanism underlying NOTCH-induced and ubiquitin-mediated JAK3 degradation.SOCS regulation of the JAK/STAT signalling pathway.JAK2 inhibition sensitizes resistant EGFR-mutant lung adenocarcinoma to tyrosine kinase inhibitors Interactions between HIV-1 Vif and human ElonginB-ElonginC are important for CBF-β binding to Vif.Drosophila SOCS36E negatively regulates JAK/STAT pathway signaling via two separable mechanisms.Suppression of cytokine signaling: the SOCS perspective.The SOCS box encodes a hierarchy of affinities for Cullin5: implications for ubiquitin ligase formation and cytokine signalling suppression The origin of allosteric functional modulation: multiple pre-existing pathways.Mechanism of suppressors of cytokine signaling 1 inhibition of epithelial-mesenchymal transition signaling through ROS regulation in colon cancer cells: suppression of Src leading to thioredoxin up-regulation.Inhibition of IL-6 family cytokines by SOCS3.Characterization of key transcription factors as molecular signatures of HPV-positive and HPV-negative oral cancers.The SOCS box-adapting proteins for ubiquitination and proteasomal degradation.SOCS proteins in development and disease.SOCS proteins in regulation of receptor tyrosine kinase signaling.Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player.The assembly of Vif ubiquitin E3 ligase for APOBEC3 degradation.

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Structure of the SOCS4-ElonginB/C Complex Reveals a Distinct SOCS Box Interface and the Molecular Basis for SOCS-Dependent EGFR Degradation

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2007 nî lūn-bûn

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2007 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

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2007 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2007年の論文

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Structure of the SOCS4-Elongin ...... OCS-Dependent EGFR Degradation

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Structure of the SOCS4-Elongin ...... OCS-Dependent EGFR Degradation

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Structure of the SOCS4-Elongin ...... OCS-Dependent EGFR Degradation

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Structure of the SOCS4-Elongin ...... OCS-Dependent EGFR Degradation

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Structure of the SOCS4-Elongin ...... OCS-Dependent EGFR Degradation

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Structure of the SOCS4-Elongin ...... OCS-Dependent EGFR Degradation

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Structure of the SOCS4-Elongin ...... OCS-Dependent EGFR Degradation

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Structure of the SOCS4-Elongin ...... OCS-Dependent EGFR Degradation

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J.STR.2007.09.016

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Structure of the SOCS4-Elongin ...... OCS-Dependent EGFR Degradation

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Alex N Bullock

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Judit E Debreczeni

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Maria C Rodriguez

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Zhou Songyang

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P2860

Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function

A quantitative protein interaction network for the ErbB receptors using protein microarrays

Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex

Structural bases of unphosphorylated STAT1 association and receptor binding

Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation

Independent binding of peptide ligands to the SH2 and SH3 domains of Grb2

A family of cytokine-inducible inhibitors of signalling

Twenty proteins containing a C-terminal SOCS box form five structural classes

Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

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1493-504

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10.1016/J.STR.2007.09.016

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11

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15

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5848869

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17997974

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structural biology

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2225448

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