Structures of human Pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity
about
A universal code for RNA recognition by PUF proteinsComparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory systemStructural basis for specific recognition of multiple mRNA targets by a PUF regulatory proteinA 5' cytosine binding pocket in Puf3p specifies regulation of mitochondrial mRNAsStacking interactions in PUF-RNA complexesAlternate Modes of Cognate RNA Recognition by Human PUMILIO ProteinsPatterns and plasticity in RNA-protein interactions enable recruitment of multiple proteins through a single siteAn artificial PPR scaffold for programmable RNA recognitionDivergent RNA binding specificity of yeast Puf2p.Evolutionary Conservation and Diversification of Puf RNA Binding Proteins and Their mRNA TargetsThe Puf-family RNA-binding protein PfPuf2 regulates sexual development and sex differentiation in the malaria parasite Plasmodium falciparumThe Puf family of RNA-binding proteins in plants: phylogeny, structural modeling, activity and subcellular localizationMicroRNAs: Meta-controllers of gene expression in synaptic activity emerge as genetic and diagnostic markers of human diseaseNucleic acid recognition by tandem helical repeats.Modular assembly of designer PUF proteins for specific post-transcriptional regulation of endogenous RNAConditional regulation of Puf1p, Puf4p, and Puf5p activity alters YHB1 mRNA stability for a rapid response to toxic nitric oxide stress in yeast.Brat promotes stem cell differentiation via control of a bistable switch that restricts BMP signaling.Targeted translational regulation using the PUF protein family scaffold.A conserved PUF-Ago-eEF1A complex attenuates translation elongation.De-coding and re-coding RNA recognition by PUF and PPR repeat proteins.Engineered proteins with Pumilio/fem-3 mRNA binding factor scaffold to manipulate RNA metabolism.A single C. elegans PUF protein binds RNA in multiple modes.Understanding and engineering RNA sequence specificity of PUF proteins.Pentatricopeptide repeats: modular blocks for building RNA-binding proteins.Carbon source-dependent alteration of Puf3p activity mediates rapid changes in the stabilities of mRNAs involved in mitochondrial function.Roles of Puf proteins in mRNA degradation and translation.Modular recognition of nucleic acids by PUF, TALE and PPR proteins.Engineering RNA-binding proteins for biologyEngineering reprogrammable RNA-binding proteins for study and manipulation of the transcriptome.A Caenorhabditis elegans PUF protein family with distinct RNA binding specificity.Co-occupancy of two Pumilio molecules on a single hunchback NRE.Engineering specificity changes on a RanBP2 zinc finger that binds single-stranded RNA.Structural basis for the specific recognition of 18S rRNA by APUM23.Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.The PUF Protein Family: Overview on PUF RNA Targets, Biological Functions, and Post Transcriptional Regulation.Expanding RNA binding specificity and affinity of engineered PUF domains.
P2860
Q24302432-9372C99F-55E4-40C5-B6B3-AF7849666E24Q24311402-8CBDC488-63CA-4F19-9FBA-00863C22D344Q27658119-E21B95D0-DD27-41DA-9C79-4D85EF833370Q27658210-F032F1EB-9BA9-4802-B5DE-897FA28638A5Q27667163-0649DE76-58C7-4873-B105-D6BFE6D4D795Q27667258-37F7EA78-F508-4397-A08C-0D6101746E3AQ27678290-655A092E-D8D3-4C45-AA15-A64672588B33Q27696871-A18C3C74-D4DE-4680-BC07-A992C0B02A3BQ27938055-1185E995-E943-40A7-94DF-8C893ECC1B28Q28607160-0109E1F7-A55C-4CF4-82AC-E11302E45953Q30043858-EBF40824-19D6-4879-8023-6BE36A39B0C4Q30493950-F84AA688-CD7C-41EB-ADD4-D9C7D816C007Q34594189-F0956DE8-BC73-4670-B950-9E14FCA96EB9Q34634182-F04801EA-6FBD-43E2-96EB-7AE7294A13CCQ35104815-CDA04010-7044-4E5A-8424-038E6769FB51Q35170986-581B121F-CA99-448C-B438-D481C59793E6Q35226321-74A6424B-04EB-4562-94B6-110C3286F5C2Q35229203-8908AFC6-31AF-41BE-99B8-F4786546FA08Q35801081-5E6F4AEA-CA07-4E47-ADAC-15192EB95437Q36591600-04FFB6C9-C0ED-4004-A697-F551AFADBF6BQ37158566-974A2E1F-D6EB-4577-BB6A-8775F5DEEF6BQ37200672-DE3328C3-04C2-42E8-8B51-9ED0C362B2ECQ37357769-7ACE007A-E27D-4742-A262-E694F772F273Q37381218-F17497A1-AABA-4E10-8ADC-614FDA18FDF3Q37680351-7E9369A2-A151-42A4-B201-FE451C059D08Q37940431-E4ED4D3F-8668-40F7-A46C-46EF4DE4F723Q37974831-2FC4CCC7-3F94-45B2-8830-351B44EC5696Q38112460-BDFDDF0D-07B2-4E28-8A17-39B33FC188E5Q38545680-1C60B6B7-2F26-49DC-AE16-9084F3A1E329Q41209261-72E4F8E1-E72D-46B4-AC51-941EBD551072Q42776870-ECE9A4F3-FB5E-427D-8C41-20F17BE5634FQ44848875-ACADE01D-E7BD-4C8C-BF9F-8702D68CED28Q47113913-58B5714B-8CEB-44F2-889C-1B24B3D6E02FQ47374122-F775680D-C177-46BD-8509-6FBAFE5A958CQ49550228-55C51502-0664-4F25-92EC-D6DEE5756B2FQ52681299-78460BD2-06EC-4D1E-8E63-244D8442715E
P2860
Structures of human Pumilio with noncognate RNAs reveal molecular mechanisms for binding promiscuity
description
2008 nî lūn-bûn
@nan
2008 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structures of human Pumilio wi ...... anisms for binding promiscuity
@ast
Structures of human Pumilio wi ...... anisms for binding promiscuity
@en
Structures of human Pumilio wi ...... anisms for binding promiscuity
@nl
type
label
Structures of human Pumilio wi ...... anisms for binding promiscuity
@ast
Structures of human Pumilio wi ...... anisms for binding promiscuity
@en
Structures of human Pumilio wi ...... anisms for binding promiscuity
@nl
prefLabel
Structures of human Pumilio wi ...... anisms for binding promiscuity
@ast
Structures of human Pumilio wi ...... anisms for binding promiscuity
@en
Structures of human Pumilio wi ...... anisms for binding promiscuity
@nl
P2093
P1433
P1476
Structures of human Pumilio wi ...... anisms for binding promiscuity
@en
P2093
Aneel K Aggarwal
Deepak T Nair
Robin P Wharton
P304
P356
10.1016/J.STR.2008.01.006
P50
P577
2008-04-01T00:00:00Z