Structure of the open conformation of a functional chimeric NADPH cytochrome P450 reductase
about
Conformational Changes of NADPH-Cytochrome P450 Oxidoreductase Are Essential for Catalysis and Cofactor BindingStructural basis for the electron transfer from an open form of NADPH-cytochrome P450 oxidoreductase to heme oxygenaseBiochemical comparison of Anopheles gambiae and human NADPH P450 reductases reveals different 2'-5'-ADP and FMN binding traitsCoupled motions direct electrons along human microsomal P450 ChainsNADPH-cytochrome P450 oxidoreductase: prototypic member of the diflavin reductase family.Modulation of the cytochrome P450 reductase redox potential by the phospholipid bilayer.Human cytochrome P450 oxidoreductase deficiency caused by the Y181D mutation: molecular consequences and rescue of defect.Holoenzyme structures of endothelial nitric oxide synthase - an allosteric role for calmodulin in pivoting the FMN domain for electron transferDistinct conformational behaviors of four mammalian dual-flavin reductases (cytochrome P450 reductase, methionine synthase reductase, neuronal nitric oxide synthase, endothelial nitric oxide synthase) determine their unique catalytic profiles.A kinetic model linking protein conformational motions, interflavin electron transfer and electron flux through a dual-flavin enzyme-simulating the reductase activity of the endothelial and neuronal nitric oxide synthase flavoprotein domains.SERR Spectroelectrochemical Study of Cytochrome cd1 Nitrite Reductase Co-Immobilized with Physiological Redox Partner Cytochrome c552 on Biocompatible Metal Electrodes.The sulfur/sulfonates transport systems in Xanthomonas citri pv. citriReal-time analysis of conformational control in electron transfer reactions of human cytochrome P450 reductase with cytochrome cAltered human CYP3A4 activity caused by Antley-Bixler syndrome-related variants of NADPH-cytochrome P450 oxidoreductase measured in a robust in vitro systemGenetic variations in NADPH-CYP450 oxidoreductase in a Czech Slavic cohort.Gating mechanisms for biological electron transfer: integrating structure with biophysics reveals the nature of redox control in cytochrome P450 reductase and copper-dependent nitrite reductase.Dynamic control of electron transfers in diflavin reductases.Instability of the Human Cytochrome P450 Reductase A287P Variant Is the Major Contributor to Its Antley-Bixler Syndrome-like Phenotype.Structure of the Arabidopsis thaliana NADPH-cytochrome P450 reductase 2 (ATR2) provides insight into its function.A well-balanced preexisting equilibrium governs electron flux efficiency of a multidomain diflavin reductase.Altered CYP19A1 and CYP3A4 Activities Due to Mutations A115V, T142A, Q153R and P284L in the Human P450 Oxidoreductase.Redox-linked domain movements in the catalytic cycle of cytochrome p450 reductase.Domain motion in cytochrome P450 reductase: conformational equilibria revealed by NMR and small-angle x-ray scattering.Molecular dynamics simulations give insight into the conformational change, complex formation, and electron transfer pathway for cytochrome P450 reductase.FMN binding site of yeast NADPH-cytochrome P450 reductase exposed at the surface is highly specificElectron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: the effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium.The Hinge Segment of Human NADPH-Cytochrome P450 Reductase in Conformational Switching: The Critical Role of Ionic Strength.Restricting the conformational freedom of the neuronal nitric-oxide synthase flavoprotein domain reveals impact on electron transfer and catalysis.Direct observation of multiple conformational states in Cytochrome P450 oxidoreductase and their modulation by membrane environment and ionic strengthDetection of a Protein Conformational Equilibrium by Electrospray Ionisation-Ion Mobility-Mass Spectrometry
P2860
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P2860
Structure of the open conformation of a functional chimeric NADPH cytochrome P450 reductase
description
2009 nî lūn-bûn
@nan
2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Structure of the open conforma ...... ADPH cytochrome P450 reductase
@ast
Structure of the open conforma ...... ADPH cytochrome P450 reductase
@en
Structure of the open conforma ...... ADPH cytochrome P450 reductase
@nl
type
label
Structure of the open conforma ...... ADPH cytochrome P450 reductase
@ast
Structure of the open conforma ...... ADPH cytochrome P450 reductase
@en
Structure of the open conforma ...... ADPH cytochrome P450 reductase
@nl
prefLabel
Structure of the open conforma ...... ADPH cytochrome P450 reductase
@ast
Structure of the open conforma ...... ADPH cytochrome P450 reductase
@en
Structure of the open conforma ...... ADPH cytochrome P450 reductase
@nl
P2093
P2860
P356
P1433
P1476
Structure of the open conforma ...... ADPH cytochrome P450 reductase
@en
P2093
Denis Pompon
Gilles Truan
Louise Aigrain
P2860
P356
10.1038/EMBOR.2009.82
P577
2009-07-01T00:00:00Z