Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor
about
Collective dynamics differentiates functional divergence in protein evolutionOrg 214007-0: a novel non-steroidal selective glucocorticoid receptor modulator with full anti-inflammatory properties and improved therapeutic indexStructure of a 13-fold superhelix (almost) determined from first principles.Investigation on critical structural motifs of ligands for triggering glucocorticoid receptor nuclear migration through molecular docking simulations.Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay.Ligand binding domain mutations of the glucocorticoid receptor selectively modify the effects with, but not binding of, cofactors.The road less traveled: new views of steroid receptor action from the path of dose-response curves.Structure of the glucocorticoid receptor, a flexible protein that can adapt to different ligands.The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights.Recent advances in the development of novel glucocorticoid receptor modulators.Illuminating intracellular signaling and molecules for single cell analysis.De novo design: balancing novelty and confined chemical space.Understanding how long-acting β2 -adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids in asthma - an update.Discovery of GW870086: a potent anti-inflammatory steroid with a unique pharmacological profileAn analysis of glucocorticoid receptor-mediated gene expression in BEAS-2B human airway epithelial cells identifies distinct, ligand-directed, transcription profiles with implications for asthma therapeutics.Crystalline forms of 2,2,2-trifluoro-N-[(1R,2S)-1-{[1-(4-fluorophenyl)-1H-indazol-5-yl]oxy}-1-(3-methoxyphenyl)-2-propanyl]acetamide (AZD-5423).Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads.Workflows and performances in the ranking prediction of 2016 D3R Grand Challenge 2: lessons learned from a collaborative effort.An Approach to Greater Specificity for Glucocorticoids.
P2860
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P2860
Design and x-ray crystal structures of high-potency nonsteroidal glucocorticoid agonists exploiting a novel binding site on the receptor
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Design and x-ray crystal struc ...... l binding site on the receptor
@ast
Design and x-ray crystal struc ...... l binding site on the receptor
@en
Design and x-ray crystal struc ...... l binding site on the receptor
@nl
type
label
Design and x-ray crystal struc ...... l binding site on the receptor
@ast
Design and x-ray crystal struc ...... l binding site on the receptor
@en
Design and x-ray crystal struc ...... l binding site on the receptor
@nl
prefLabel
Design and x-ray crystal struc ...... l binding site on the receptor
@ast
Design and x-ray crystal struc ...... l binding site on the receptor
@en
Design and x-ray crystal struc ...... l binding site on the receptor
@nl
P2093
P2860
P921
P356
P1476
Design and x-ray crystal struc ...... l binding site on the receptor
@en
P2093
David House
Diane M Coe
Iain J Uings
Iain M McLay
Keith Biggadike
Kevin P Madauss
Marie A Iannone
Randy K Bledsoe
Shawn P Williams
Simon J F Macdonald
P2860
P304
P356
10.1073/PNAS.0909125106
P407
P577
2009-10-27T00:00:00Z